Advanced Science, EarlyView.Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang +9 more
wiley +1 more source
Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy
Advanced Science, EarlyView.A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang +8 more
wiley +1 more source
The Urban Gradient in Malaria-Endemic Municipalities in Acre: Revisiting the Role of Locality. [PDF]
Int J Environ Res Public Health, 2018 Dal'Asta AP +4 more
europepmc +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Global Mental Health and Pharmacology: The Case of Attention Deficit and Hyperactivity Disorders in Brazil. [PDF]
Front Sociol, 2020 Ortega F, Müller MR.
europepmc +1 more source
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, EarlyView.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Monitoring particles and populations : expo-urbanism and the rise of eco-governance regimes [PDF]
, 2010 Corbalan, Mauricio, Zehle, Soenke
core +2 more sources
Encoding Cumulation to Learn Perturbative Nonlinear Oscillatory Dynamics
Advanced Science, EarlyView.Weak nonlinearities critically shape the long term behavior of oscillatory systems but are difficult to identify from data. A data‐driven framework is introduced to infer governing equations of weakly nonlinear oscillators from sparse and noisy observations.
Teng Ma +5 more
wiley +1 more source
Decentralized control of human visceral leishmaniasis in endemic urban areas of Brazil: a literature review. [PDF]
Trop Med Health, 2016 Menon SS +3 more
europepmc +1 more source
Child or monk? An unpublished story attributed to John Moschos in MS Coislin 257 [PDF]
, 2008 Papaconstantinou, Arietta
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