Results 21 to 30 of about 3,361 (294)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The History and Development of British Tramways and the Impacts That It Had [PDF]

, 2017
The thesis is about the general history of the British tramways and how they developed throughout England in the nineteenth century. It includes their general development; how it affected England economically; how it affected England demographically ...
Schuldenrein, Noam
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Municipalization vs. Private Entrepreneurship: Deutsche Continental-Gas-Gesellschaft Gasworks in Warsaw, Kraków, and Lviv and their Role in the Modernization of Emerging Cities in the Second Half of the Nineteenth Century

Zeitschrift für Ostmitteleuropa-Forschung
The article discusses the mid-nineteenth-century introduction of gas production technology by the Deutsche Continental-Gas-Gesellschaft to the emerging cities in the area of the former Polish Lithuanian Commonwealth, namely Warsaw, Lviv, and Kraków ...
Tomasz Dywan
doaj   +1 more source

Uruguai: regras, procedimentos e decisões na implantação dos municípios (2010-2015)

Nuevo mundo - Mundos Nuevos, 2016
The paper analyzes the process of defining the listing of the deployed municipalities in Uruguay in 2010 and those deployed in 2015, as well as the general overview of the municipalization in the country. It has as sources the legislation on the subject,
Alvaro Augusto de Borba Barreto
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

A (re)municipalization trend among energy utilities: Truth or myth? [PDF]

, 2016
In the 1990s, a number of municipalities started privatizing their energy utilities; in recent years, there has been an intensive debate about whether a paradigm shift has taken place since then.
Cullmann, Astrid, Nieswand, Maria, Seifert, Stefan, Stiel, Caroline   +3 more
core  

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Os Municípios dos “Outros”. Alternância do poder local em Moçambique? O caso de Angoche

Cadernos de Estudos Africanos, 2015
The 2003 local elections are the beginning of the exercise of local power by Renamo in Angoche. Which are the drivers behind this electoral outcome?
Domingos Manuel do Rosário
doaj   +1 more source