Results 211 to 220 of about 9,575 (303)

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Mechanistic Insights Into Protein Aggregation Inhibition by Green-Synthesized Silver Nanoparticles: A Study on Human Lysozyme. [PDF]

IET Nanobiotechnol
Alam MT, Rauf MA, Khan A, Hussain R.
europepmc   +1 more source

Plasma proteomic profiles of patients during oral anti‐coagulant treatment with vitamin K antagonists

British Journal of Haematology, EarlyView.
Eleonora Camilleri, Bart J. M. van Vlijmen, Mettine H. A. Bos, Manfred Wuhrer, David R. Goodlett, Christoph H. Borchers, Suzanne C. Cannegieter, Nienke van Rein, Yassene Mohammed   +8 more
wiley   +1 more source

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source

An Evolutionarily Conserved Laterally Acquired Toolkit Enables Microbiota Targeting by Trichomonas. [PDF]

Mol Biol Evol
Hart AJ, Mpeyako LA, Bailey NP, Merces G, Gray J, Biboy J, Banzhaf M, Vollmer W, Hirt RP.   +8 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Decision letter: Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase

, 2020
Kelly T. Hughes
openalex   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Electrophoretic patterns of proteinuria in dogs with Cushing’s syndrome

Journal of Small Animal Practice, EarlyView.
Objectives To describe the electrophoretic pattern of proteinuria in dogs with naturally occurring Cushing’s syndrome. We hypothesised that urine protein electrophoresis in dogs with spontaneous Cushing’s syndrome will reveal glomerular proteinuria. We also hypothesised that the severity of proteinuria would decrease during treatment with trilostane ...
J. Milenkovic, T. Francey, A. Schweighauser, J. Howard, S. Kittl, M. Campos   +5 more
wiley   +1 more source