Elucidating the role of Musashi RNA-binding proteins in tubular epithelial cells and acute kidney injury [PDF]
, 2023 RNA-binding proteins (RBPs) are essential mediators of post-transcriptional gene regulation and interaction of RBPs with target RNAs fundamentally influences every step of RNA metabolism.
Seufert, Lisa
core
Musashi-2 (MSI2) regulation of DNA damage response in lung cancer
Abstract Lung cancer is one of the most common types of cancer worldwide. Non-small cell lung cancer (NSCLC), typically caused by KRAS and TP53 driver mutations, represents the majority of all new lung cancer diagnoses. Overexpression of the RNA-binding protein (RBP) Musashi-2 (MSI2) has been associated with NSCLC progression.
Igor Bychkov +9 more
openaire +2 more sources
Asian Pacific Journal of Tropical Biomedicine, 2015 Objective: To investigate the influence of CD133+ expression on patients' survival and resistance of CD133+ cells to anti-tumor agents in gastric cancer (GC).
De-Hu Chen +6 more
doaj +1 more source
PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner [PDF]
, 2021 Objectives: Details of the histogenesis of salivary gland tumors are largely unknown. The oncogenic role of PLAG1 in the salivary gland has been demonstrated in vivo.
Aota, Keiko +9 more
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Regulation of lung cancer initiation and progression by the stem cell determinant Musashi
eLifeDespite advances in therapeutic approaches, lung cancer remains the leading cause of cancer-related deaths. To understand the molecular programs underlying lung cancer initiation and maintenance, we focused on stem cell programs that are normally ...
Alison G Barber +9 more
doaj +1 more source
PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner [PDF]
, 2020 Objectives: Details of the histogenesis of salivary gland tumors are largely unknown. The oncogenic role of PLAG1 in the salivary gland has been demonstrated in vivo.
1711 +35 more
core
ResearchTumor metastasis is a major contributor for mortality in patients with pancreatic ductal adenocarcinoma (PDAC). While circular RNAs (circRNAs) have emerged as pivotal regulators of tumor progression and metastasis, their functional roles in PDAC remain ...
Zhang Li +13 more
doaj +1 more source
The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex [PDF]
, 2017 C
Althoff, Kristina +17 more
core +1 more source
Msi2 enhances muscle dysfunction in a myotonic dystrophy type 1 mouse model
Biomedical JournalBackground: Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by a CTG repeat expansion in the 3′ untranslated region of the DM1 protein kinase gene. Characteristic degenerative muscle symptoms include myotonia, atrophy, and weakness.
Maria Sabater-Arcis +5 more
doaj +1 more source
Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models [PDF]
Background: We recently reported that upregulation of Musashi 2 (MSI2) protein in the rare neuromuscular disease myotonic dystrophy type 1 contributes to the hyperactivation of the muscle catabolic processes autophagy and UPS through a reduction in miR-7
Artero Allepuz, Rubén D. +6 more
core +2 more sources