Results 41 to 50 of about 6,635 (196)

Regulation of myeloid leukaemia by the cell-fate determinant Musashi [PDF]

Nature, 2010
Chronic myelogenous leukaemia (CML) can progress from a slow growing chronic phase to an aggressive blast crisis phase, but the molecular basis of this transition remains poorly understood. Here we have used mouse models of CML to show that disease progression is regulated by the Musashi-Numb signalling axis.
Ito, Takahiro, Kwon, Hyog Young, Zimdahl, Bryan, Congdon, Kendra L., Blum, Jordan, Lento, William E., Zhao, Chen, Lagoo, Anand, Gerrard, Gareth, Foroni, Letizia, Goldman, John, Goh, Harriet, Kim, Soo-Hyun, Kim, Dong-Wook, Chuah, Charles, Oehler, Vivian G., Radich, Jerald P., Jordan, Craig T., Reya, Tannishtha   +18 more
openaire   +2 more sources

Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup‐specific prognostic stratification using economical/accessible diagnostic methods

Brain Pathology, EarlyView.
This study characterizes the molecular subgroup–specific features of a nationwide Japanese cohort comprising 242 medulloblastomas (MBs). Furthermore, we introduce SEE‐6‐CNA, a simple, cost‐effective, and FFPE‐compatible molecular test that is applicable to routine pathology samples and serves as a surrogate for risk stratification in non‐WNT/non‐SHH ...
Kohichi Go, Asako Katsuma, Ema Yoshioka, Tomoko Shofuda, Kohei Fukuoka, Koichi Ichimura, Yuko Matsushita, Yohei Mineharu, Yasuhide Makino, Takeshi Kawauchi, Atsushi Sasaki, Junko Hirato, Takeshi Inoue, Yoshinori Kodama, Masayuki Mano, Daisuke Kanematsu, Noriyuki Kijima, Naoki Kagawa, Dai Keino, Akitake Mukasa, Tomonari Suzuki, Koji Yoshimoto, Daisuke Kuga, Keishi Horiguchi, Shigeru Yamaguchi, Masayuki Kanamori, Kai Yamasaki, Kenichi Ishibashi, Takuya Akai, Masayoshi Yamaoka, Ryuji Ishizaki, Atsufumi Kawamura, Shigeo Ohba, Joji Ishida, Ryo Ando, Junya Fukai, Tomoru Miwa, Masazumi Fujii, Ai Muroi, Kuniaki Saito, Atsuko Harada, Yasuhiko Hayashi, Masahiro Nonaka, Young‐Soo Park, Yusuke Kobayashi, Tadashi Higuchi, Yosuke Miyairi, Kazuhisa Yoshifuji, Noriyoshi Takebe, Soichi Oya, Kosuke Nakajo, Mitsutoshi Nakada, Yoshiteru Nakano, Mizuki Kambara, Koji Adachi, Kazuhiro Tanaka, Hideo Nakamura, Yukihiko Sonoda, Ryuta Saito, Takafumi Wataya, Kazuhiko Kurozumi, Michael D. Taylor, Yoshitaka Narita, Soichiro Shibui, Hajime Arai, Hiroaki Sakamoto, Isao Date, Motoo Nagane, Ryo Nishikawa, Yoshiki Arakawa, Yonehiro Kanemura   +70 more
wiley   +1 more source

P-317 Impact of Musashi-1 and Musashi-2 double knockdown on Notch signaling and the pathogenesis of endometriosis

Human Reproduction, 2022
Abstract Study question Do Musashi proteins mechanistically contribute to the pathogenetic properties of endometriotic cells? Summary answer Silencing of Musashi-1 and Muashi-2 reduces the expression of stemness-related genes ...
T Strauß, B Greve, M Gabriel, L Kiesel, M Poutanen, S.D Schäfer, M Götte   +6 more
openaire   +1 more source

Development of a monoenergetic ultraslow antiproton beam source for high-precision investigation

Physical Review Special Topics. Accelerators and Beams, 2012
The ASACUSA collaboration developed an ultraslow antiproton beam source, monoenergetic ultraslow antiproton source for high-precision investigation (MUSASHI), consisting of an electromagnetic trap with a liquid He free superconducting solenoid and a low ...
N. Kuroda, H. A. Torii, Y. Nagata, M. Shibata, Y. Enomoto, H. Imao, Y. Kanai, M. Hori, H. Saitoh, H. Higaki, A. Mohri, K. Fujii, C. H. Kim, Y. Matsuda, K. Michishio, Y. Nagashima, M. Ohtsuka, K. Tanaka, Y. Yamazaki   +18 more
doaj   +1 more source

Focused Ultrasound‐Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri‐Focally Localized Glioblastoma Cells

International Journal of Cancer, Volume 159, Issue 4, Page 1005-1016, 15 August 2026.
Glioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Frieda Bayler, Jonna Holler, Jacqueline Clüver, Levi Johanning, Dana Hellmold, Nils Oliver Schröder, Jessica Nojszewski, Hajrullah Ahmeti, Carolin Kubelt‐Kwamin, Michael Synowitz, Janka Held‐Feindt   +10 more
wiley   +1 more source

Indirect and Selective Patterning Strategy of Silver Nanowires Using Elastomer Poly(vinylidene Fluoride‐Co‐Hexafluoropropylene) for Stretchable Electronics

physica status solidi (a), Volume 223, Issue 12, 24 June 2026.
An indirect and selective patterning strategy is introduced to form embedded silver nanowire (AgNW) electrodes using the interfacial adhesion contrast between e‐PVDF‐HFP and PDMS. This method enables multiscale AgNW electrode patterning without masks or etching and improves mechanical and environmental stability.
Jinbo Shim, Jinsu Yoon, Hayun Kim, Yeeun Jeong, Hyukju Go, Yongtaek Hong   +5 more
wiley   +1 more source

Legendary Samurai Miyamoto Musashi

, 2023
Background: Samurai were a Japanese medieval military force. There are several very great Japanese samurai figures who have earned the title of legendary by Japanese society. Objective: This research aims to explain one of the legendary Japanese samurai
Meliala, Matthew Haganta
core  

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, Volume 36, Issue 49, 18 June 2026.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Effects and Impact of Extensive Reading in Japanese University English for General Purpose Classes

Studies in Self-Access Learning Journal, 2018
Extensive reading is one of the language learning strategies (LLS) that has proved to have positive effects on students’ English ability such as improving their reading speed, reading fluency, and grammatical accuracy. A recent study on extensive reading
Shinobu Nakamura
doaj   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source