Results 101 to 110 of about 29,353 (245)
The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity [PDF]
The EMBO Journal, 1997 Intracellular tyrosine kinases link the G protein-coupled m1 muscarinic acetylcholine receptor (mAChR) to multiple cellular responses. However, the mechanisms by which m1 mAChRs stimulate tyrosine kinase activity and the identity of the kinases within particular signaling pathways remain largely unknown.
W, Tsai, A D, Morielli, E G, Peralta
openaire +2 more sources
Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]
, 2007 Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung +3 more
core +1 more source
Journal of Biological Chemistry, 2016 Establishing the in vivo activation status of G protein-coupled receptors would not only indicate physiological roles of G protein-coupled receptors but would also aid drug discovery by establishing drug/receptor engagement.
Adrian J Butcher +12 more
semanticscholar +1 more source
Spirocyclic Diamine Scaffolds for Medicinal Chemistry
Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel +3 more
wiley +1 more source
Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ. [PDF]
PLoS ONE, 2015 Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound healing. Neuropeptides and neurotransmitters are usually associated with neuronal signaling, but have recently been shown to be produced also by non-neuronal ...
Marta Słoniecka +5 more
doaj +1 more source
Frontiers in Neuroscience, 2017 Chronic tinnitus is characterized by neuroplastic changes of the auditory cortex. A promising method for therapy of chronic tinnitus is vagus nerve stimulation (VNS) combined with auditory stimulation.
T. Bojić +3 more
semanticscholar +1 more source
Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U +6 more
wiley +1 more source
The M1 muscarinic acetylcholine receptor agonist xanomeline suppresses lethal inflammation
The FASEB Journal, 2009 We have recently indicated a role for brain muscarinic acetylcholine receptors in controlling systemic inflammatory responses (Proc Natl Acad Sci USA, 2006, 5219; Brain Behav Immun, Epub). Here we studied whether xanomeline, a centrally‐acting M1 muscarinic receptor agonist, suppresses the systemic cytokine ...
Valentin A. Pavlov +5 more
openaire +1 more source
Journal of Pharmacological Sciences, 2008 Lymphocytes possess all the components required to constitute an independent, non-neuronal cholinergic system. These include acetylcholine (ACh); choline acetyltransferase (ChAT), its synthesizing enzyme; and both muscarinic and nicotinic ACh receptors ...
Takeshi Fujii +2 more
doaj +1 more source
Scientific Reports, 2022 Cholinergic activation can enhance glutamatergic activity in the hippocampus under pathologic conditions, such as Alzheimer’s disease. The aim of the present study was to elucidate the relationship between glutamatergic neural functional decline and ...
Kengo Suzuki +10 more
doaj +1 more source