Results 101 to 110 of about 15,706 (256)

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of an Independent, Non-neuronal Cholinergic System in Lymphocytes and Its Clinical Significance in Immunotherapy

Journal of Pharmacological Sciences, 2008
Lymphocytes possess all the components required to constitute an independent, non-neuronal cholinergic system. These include acetylcholine (ACh); choline acetyltransferase (ChAT), its synthesizing enzyme; and both muscarinic and nicotinic ACh receptors ...
Takeshi Fujii, Yuki Takada-Takatori, Koichiro Kawashima   +2 more
doaj   +1 more source

Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice

Scientific Reports, 2022
Cholinergic activation can enhance glutamatergic activity in the hippocampus under pathologic conditions, such as Alzheimer’s disease. The aim of the present study was to elucidate the relationship between glutamatergic neural functional decline and ...
Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukawa   +10 more
doaj   +1 more source

Pharmacological differentiation of presynaptic M1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum [PDF]

General Pharmacology: The Vascular System, 1990
1. Effects of three muscarinic antagonists on electrically evoked ACh release and contractile response were investigated in longitudinal muscle strips of guinea-pig ileum suspended in an organ-bath and superfused with Krebs solution. ACh release was determined by a specific radioimmunoassay. 2.
K, Kawashima, K, Fujimoto, T, Suzuki, H, Oohata   +3 more
openaire   +2 more sources

Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]

, 2013
Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
core   +1 more source

Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms

Pharmacological Research, 2015
We mutated key amino acids of the human variant of the M1 muscarinic receptor that target ligand binding, receptor activation, and receptor-G protein interaction. We compared the effects of these mutations on the action of two atypical M1 functionally preferring agonists (N-desmethylclozapine and xanomeline) and two classical non-selective orthosteric ...
Randáková, Alena, Dolejší, Eva, Rudajev, Vladimír, Zimčík, Pavel, Doležal, Vladimír, El-Fakahany, Esam E., Jakubík, Jan   +6 more
openaire   +2 more sources

Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]

, 2018
Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +1 more source

The role of hippocampal NMDA receptors in long-term emotional responses following muscarinic receptor activation [PDF]

, 2016
Extensive evidence indicates the influence of the cholinergic system on emotional processing. Previous findings provided new insights into the underlying mechanisms of long-term anxiety, showing that rats injected with a single systemic dose of ...
Bicca, Maira A., Bortolotto, Zuner A., Collingridge, Graham L., Costa, Ana Paula R, De Lima, Thereza C M, Hoeller, Alexandre A., Lach, Gilliard, Lightman, Stafford L., Matheus, Filipe C., Spiga, Francesca, Walz, Roger   +10 more
core   +4 more sources

Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity

Ibrain, Volume 11, Issue 4, Page 403-421, Winter 2025.
Synaptic adhesion molecules (SAM) are essential for the formation, maturation, function, plasticity, and assembly of synaptic connections, all critical for normal neurodevelopment. Excessive exposure to neurotoxic metals during development could disrupt the developing brain and potentially lead to neurodevelopmental disorders (NDDs).
Toheeb O. Oyerinde, Victor E. Anadu, Tobiloba S. Olajide, Ileje I. Ukwubile, Olayemi K. Ijomone, Kingsley A. Iteire, Michael Aschner, Omamuyovwi M. Ijomone   +7 more
wiley   +1 more source

T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk

Pharmacology Research & Perspectives, 2020
M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in animals.
Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura   +8 more
doaj   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li, Fangfang Li, Yang Tang, Siyu Guo, Yihan Yao, Yuan Fang, Bicheng Zhang, Yu Jiang, Jing Wang, Dang Wu, Jianxia Cheng, Zhihui Huang, Zengfeng Xin, Ting Zhang   +13 more
wiley   +1 more source