Results 111 to 120 of about 29,153 (282)

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

, 2006
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
58998, 58999, IINO, Satoshi, NOJYO, Yoshiaki   +3 more
core   +1 more source

Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice

Scientific Reports, 2022
Cholinergic activation can enhance glutamatergic activity in the hippocampus under pathologic conditions, such as Alzheimer’s disease. The aim of the present study was to elucidate the relationship between glutamatergic neural functional decline and ...
Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukawa   +10 more
doaj   +1 more source

Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome

Movement Disorders Clinical Practice, Volume 12, Issue 9, Page 1313-1325, September 2025.
Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, a sociable demeanor, and abnormal movements. People with AS often exhibit multiple types of abnormal movements, including nonepileptic myoclonus, tremor, and dystonia, which hamper attempts to identify phenomenology
Robert P. Carson, Heather Riordan, Brittany Short, Thomas Davis, John Fang, Andrew Giritharan, David A. Isaacs, Joanna Blackburn, Bhooma Aravamuthan   +8 more
wiley   +1 more source

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of an Independent, Non-neuronal Cholinergic System in Lymphocytes and Its Clinical Significance in Immunotherapy

Journal of Pharmacological Sciences, 2008
Lymphocytes possess all the components required to constitute an independent, non-neuronal cholinergic system. These include acetylcholine (ACh); choline acetyltransferase (ChAT), its synthesizing enzyme; and both muscarinic and nicotinic ACh receptors ...
Takeshi Fujii, Yuki Takada-Takatori, Koichiro Kawashima   +2 more
doaj   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, Volume 40, Issue 8, Page 1584-1594, August 2025.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Beyond the Surface: Investigating the Potential Mechanisms of Non‐Motor Symptoms in Myasthenia Gravis

European Journal of Neurology, Volume 32, Issue 8, August 2025.
We review the non‐motor symptoms of MG and their potential pathogenesis, hoping to contribute to personalized diagnosis and treatment. ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction (NMJ), driven by T cells, mediated by B cells, and dependent on autoantibodies.
Benqiao Wang, Dan Liu, Yingying Yang, Ruixia Zhu   +3 more
wiley   +1 more source

Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl‐L‐Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain

European Journal of Neurology, Volume 32, Issue 8, August 2025.
This monocentric observational study investigates a fixed combination of acetyl‐L‐carnitine, palmitoylethanolamide, and alpha‐lipoic acid in 48 patients with acute low back pain. Over 8 weeks, treatment led to significant reductions in neuropathic pain scores, decreased NSAID consumption, and improvements in quality of life, supporting its potential ...
Mattia Cominacini, Maria Teresa Valenti, Michele Braggio, Alberto Caramori, Ermes Vedovi, Luca Dalle Carbonare   +5 more
wiley   +1 more source

Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity [PDF]

, 2015
Septic encephalopathy is associated with rapid deterioration of cortical functions. Using magnetic resonance imaging (MRI) we detected functional abnormalities in the hippocampal formation of patients with septic delirium.
Bading, Hilmar, Bengtson, C. Peter, Brenner, Thorsten, Hofer, Stefan, Schmidt, Karsten, Sedlaczek, Oliver, von Haken, Rebecca, Weigand, Markus A., Zivkovic, Aleksandar R.   +8 more
core   +1 more source

T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk

Pharmacology Research & Perspectives, 2020
M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in animals.
Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura   +8 more
doaj   +1 more source