Results 111 to 120 of about 15,706 (256)

Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]

, 2007
Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung, Li, Bo, Scarselli, Marco, Wess, Jürgen   +3 more
core   +1 more source

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies

Movement Disorders, Volume 40, Issue 12, Page 2664-2677, December 2025.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill, Anna Ignatavicius, Ajay Konuri, Jack Anderson, Natasha Taylor, Simon J.G. Lewis, Elie Matar   +6 more
wiley   +1 more source

The novel orthosteric agonist M1 muscarinic acetylcholine receptor reveals anti-Alzheimer’s disease activity

Scientific Reports
Cholinergic treatments with an emphasis on M1 muscarinic acetylcholine receptor (mAChR) agonists as potential modulating agents are a new approach in Alzheimer’s disease (AD) therapy. In previous research, we designed and characterized novel thiazolidine-
Maryam Taheri, Maryam Afzali Mehr, Hossein Ghafouri   +2 more
doaj   +1 more source

Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons [PDF]

, 2006
Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer's disease. Immunohistochemical studies suggest that some of these neurons contain
Abogadie, FC, Allen, TGJ, Brown, DA
core   +1 more source

Neuronal Reshaping of the Tumor Microenvironment in Tumorigenesis and Metastasis: Bench to Clinic

Medicine Advances, Volume 3, Issue 4, Page 364-371, December 2025.
This graphical abstract illustrates the multidimensional crosstalk between neurons and tumor microenvironment as well as targeted intervention strategies identified in the study. It highlights three core interaction axes: nerve‐tumor crosstalk mediated by neurotransmitters and neurotrophic factors, neuro‐vascular communication driving angiogenesis via ...
Yimao Wu, Ruowei Sun, Shuai Ren, Gokhan Zengin, Mengyao Li   +4 more
wiley   +1 more source

Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.

PLoS ONE, 2019
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter, Laura Klein, Christin Helmschrodt, Angelika Richter   +3 more
doaj   +1 more source

Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]

, 1999
The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC, Brown, DA, Buckley, NJ, Delmas, P, Hadley, JK, London, B, Selyanko, AA, Wood, IC   +7 more
core   +1 more source

A Transfected m1 Muscarinic Acetylcholine Receptor Stimulates Adenylate Cyclase via Phosphatidylinositol Hydrolysis

Journal of Biological Chemistry, 1989
The m1 muscarinic acetylcholine receptor gene was transfected into and stably expressed in A9 L cells. The muscarinic receptor agonist, carbachol, stimulated inositol phosphate generation, arachidonic acid release, and cAMP accumulation in these cells.
C C, Felder, R Y, Kanterman, A L, Ma, J, Axelrod   +3 more
openaire   +2 more sources

Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity [PDF]

, 2015
Septic encephalopathy is associated with rapid deterioration of cortical functions. Using magnetic resonance imaging (MRI) we detected functional abnormalities in the hippocampal formation of patients with septic delirium.
Bading, Hilmar, Bengtson, C. Peter, Brenner, Thorsten, Hofer, Stefan, Schmidt, Karsten, Sedlaczek, Oliver, von Haken, Rebecca, Weigand, Markus A., Zivkovic, Aleksandar R.   +8 more
core   +1 more source

Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M₁. [PDF]

Bioorg Med Chem Lett, 2021
Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM.   +10 more
europepmc   +1 more source