Results 121 to 130 of about 29,153 (282)
The role of hippocampal NMDA receptors in long-term emotional responses following muscarinic receptor activation [PDF]
, 2016 Extensive evidence indicates the influence of the cholinergic system on emotional processing. Previous findings provided new insights into the underlying mechanisms of long-term anxiety, showing that rats injected with a single systemic dose of ...
Bicca, Maira A. +10 more
core +3 more sources
British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
PLoS ONE, 2019 In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter +3 more
doaj +1 more source
Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]
, 2018 Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara +3 more
core +1 more source
Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1. [PDF]
Bioorg Med Chem Lett, 2021 Spearing PK +10 more
europepmc +1 more source
Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons [PDF]
, 2002 The cholinergic system is thought to play an important role in hippocampal-dependent learning and memory. However, the mechanism of action of the cholinergic system in these actions in not well understood.
Power, JM, Sah, P
core +2 more sources
Frontiers in Molecular NeuroscienceFive muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao +4 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2014 Background/ Aims: Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide public health burdens.
Rosiane A. Miranda +10 more
doaj +1 more source
The M1 muscarinic acetylcholine receptor agonist xanomeline suppresses lethal inflammation
The FASEB Journal, 2009 We have recently indicated a role for brain muscarinic acetylcholine receptors in controlling systemic inflammatory responses (Proc Natl Acad Sci USA, 2006, 5219; Brain Behav Immun, Epub). Here we studied whether xanomeline, a centrally‐acting M1 muscarinic receptor agonist, suppresses the systemic cytokine response and improves survival during lethal ...
Mauricio Rosas-Ballina +5 more
openaire +1 more source