Results 121 to 130 of about 15,706 (256)

Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons [PDF]

, 2002
The cholinergic system is thought to play an important role in hippocampal-dependent learning and memory. However, the mechanism of action of the cholinergic system in these actions in not well understood.
Power, JM, Sah, P
core   +2 more sources

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets

Cellular Physiology and Biochemistry, 2014
Background/ Aims: Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide public health burdens.
Rosiane A. Miranda, Aryane R. Agostinho, Isis H. Trevenzoli, Luiz F. Barella, Claudinéia C. S. Franco, Amanda B. Trombini, Ananda Malta, Clarice Gravena, Rosana Torrezan, Paulo C. F. Mathias, Júlio C. de Oliveira   +10 more
doaj   +1 more source

Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors [PDF]

, 1995
We constructed chimeras of the rat beta 2 and beta 4 neuronal nicotinic subunits to locate the regions that contribute to differences between the acetylcholine (ACh) dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 receptors ...
Cohen, B. N., Davidson, N., Figl, A., Labarca, C., Lester, H. A., Quick, M. W.   +5 more
core   +2 more sources

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Acevedo, Antje Banning, Boman, Bonner, Caulfield, Caumont, Cheng, Claing, Coso, Crespo, Dascher, Delaney, Elorza, Ferguson, Fisher, Franco, Frucht, Grando, Grando, Hawes, Hawes, He, Hein, Hulme, Jin, Jones, Jones, Lee, Lee, Leiros, Lenhard, McCole, Michal, Miyakawa, Nguyen, Pals-Rylaarsdam, Pals-Rylaarsdam, Pitcher, Prenzel, Reiner, Ritva Tikkanen, Roseberry, Rosenblum, Shah, Simone Bocksberger, Sina Kühne, Taylor, Tohgo, Tsuga, van Biesen, van Koppen, Vogler, Vogler, Wang, Wickman, Williams, Wu, Wymke Ockenga, Zhang   +58 more
core   +3 more sources

Ipratropium Bromide-Mediated Myocardial Injury in In Vitro Models of Myocardial Ischaemia/Reperfusion [PDF]

, 2014
Ipratropium bromide, a nonselective muscarinic antagonist, is widely prescribed for the treatment of chronic obstructive pulmonary disease (COPD). Analyses of COPD patients, with underlying ischaemic heart disease, receiving anticholinergics, have ...
Harvey, Kate L., Hussain, Afthab, Maddock, Helen L.   +2 more
core   +1 more source

Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjögren Syndrome [PDF]

, 2014
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors of M3 in salivary gland and M1 ...
Borda, Enri Santiago, Reina, Silvia Lorena   +1 more
core   +1 more source

The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia

Frontiers in Psychiatry
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with ...
Samantha E. Yohn, Phillip D. Harvey, Stephen K. Brannan, William P. Horan, William P. Horan   +4 more
doaj   +1 more source

Acetylcholine autoexcites the release of proopiomelanocortin-derived peptides from melanotrope cells of Xenopus laevis via an M1 muscarinic receptor. [PDF]

, 1996
F. J. Van Strien, Eric W. Roubos, Hubert Vaudry, Bruce G. Jenks   +3 more
openalex   +1 more source

Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]

, 2012
Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
core   +1 more source