Results 131 to 140 of about 28,733 (280)

M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance

Current Research in Neurobiology, 2021
The recurrent excitatory circuits in dlPFC underlying working memory are known to require activation of glutamatergic NMDA receptors (NMDAR). The neurons in these circuits also rely on acetylcholine to maintain persistent activity, with evidence for ...
Veronica C. Galvin, Shengtao Yang, Adam S. Lowet, Dibyadeep Datta, Alvaro Duque, Amy FT. Arnsten, Min Wang   +6 more
doaj  

Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets

Cellular Physiology and Biochemistry, 2014
Background/ Aims: Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide public health burdens.
Rosiane A. Miranda, Aryane R. Agostinho, Isis H. Trevenzoli, Luiz F. Barella, Claudinéia C. S. Franco, Amanda B. Trombini, Ananda Malta, Clarice Gravena, Rosana Torrezan, Paulo C. F. Mathias, Júlio C. de Oliveira   +10 more
doaj   +1 more source

Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M₁. [PDF]

Bioorg Med Chem Lett, 2021
Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM.   +10 more
europepmc   +1 more source

Cholinergic and endocannabinoid neuromodulatory effects overlap on neurons of the pedunculopontine nucleus of mice [PDF]

, 2015
The pedunculopontine nucleus (PPN) is a part of the reticular activating system and one of the main sources of the cholinergic fibers in the midbrain, while it is also subject to cholinergic modulation.
Bordas, Csilla, Kovács, Adrienn, Pál, Balázs Zoltán   +2 more
core   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]

, 2011
Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago, Passafaro, Daniela, Reina, Silvia, Sterin Borda, Leonor   +3 more
core   +1 more source

A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]

, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Marsango, Sara, Millan, Mark J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +6 more
core   +2 more sources

The M1 muscarinic acetylcholine receptor agonist xanomeline suppresses lethal inflammation

The FASEB Journal, 2009
We have recently indicated a role for brain muscarinic acetylcholine receptors in controlling systemic inflammatory responses (Proc Natl Acad Sci USA, 2006, 5219; Brain Behav Immun, Epub). Here we studied whether xanomeline, a centrally‐acting M1 muscarinic receptor agonist, suppresses the systemic cytokine response and improves survival during lethal ...
Mauricio Rosas-Ballina, Mahendar Ochani, Kevin J. Tracey, Kanta Ochani, Yousef Al-Abed, Valentin A. Pavlov   +5 more
openaire   +1 more source

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source

Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity [PDF]

, 2015
Septic encephalopathy is associated with rapid deterioration of cortical functions. Using magnetic resonance imaging (MRI) we detected functional abnormalities in the hippocampal formation of patients with septic delirium.
Bading, Hilmar, Bengtson, C. Peter, Brenner, Thorsten, Hofer, Stefan, Schmidt, Karsten, Sedlaczek, Oliver, von Haken, Rebecca, Weigand, Markus A., Zivkovic, Aleksandar R.   +8 more
core   +1 more source