Results 141 to 150 of about 28,733 (280)

Agonist‐induced Transfer of the α Subunits of the Guanine‐nucleotide‐binding Regulatory Proteins G_q and G₁₁, and of Muscarinic m1 Acetylcholine Receptors from Plasma Membranes to a Light‐vesicular Membrane Fraction [PDF]

, 1994
Petr Svoboda, Graeme Milligan
openalex   +1 more source

Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]

, 2007
Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung, Li, Bo, Scarselli, Marco, Wess, Jürgen   +3 more
core   +1 more source

Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers.

European journal of medicinal chemistry, 2020
Marius Ozenil, Katharina Pacher, T. Balber, C. Vraka, A. Roller, W. Holzer, H. Spreitzer, M. Mitterhauser, W. Wadsak, M. Hacker, V. Pichler   +10 more
semanticscholar   +1 more source

Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior [PDF]

, 2016
Current antipsychotics are effective in treating the positive symptoms associated with schizophrenia, but they remain suboptimal in targeting cognitive dysfunction.
Arthur Christopoulos, Bakshi, Christopher J. Langmead, Christos Pantelis, Daniel T. Malone, David M. Shackleford, Johnathan R. Lane, Kwok H. C. Choy, Lee, Matsuo, Pantelis, Patrick M. Sexton, Peter J. Scammells, Rahul T. Patil, Shailesh N. Mistry   +14 more
core   +1 more source

Activation of M1 cholinergic receptors in mouse somatosensory cortex enhances information processing and detection behaviour

Communications Biology
To optimise sensory representations based on environmental demands, the activity of cortical neurons is regulated by neuromodulators such as Acetylcholine (ACh).
Wricha Mishra, Ehsan Kheradpezhouh, Ehsan Arabzadeh   +2 more
doaj   +1 more source

A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies [PDF]

, 2020
Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein.
Borden, Philip M., Fan, Chengcheng, Lester, Henry A., Rees, Douglas C., Shivange, Amol V.   +4 more
core  

Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice [PDF]

, 2001
David J. Gerber, Tatyana D. Sotnikova, Raul R. Gainetdinov, Shu Ying Huang, Marc G. Caron, Susumu Tonegawa   +5 more
openalex   +1 more source

RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling [PDF]

, 2004
Leah S. Bernstein, Suneela Ramineni, Chris Hague, Wendy Cladman, Peter Chidiac, Allan I. Levey, John R. Hepler   +6 more
openalex   +1 more source

Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice

IBRO Neuroscience Reports, 2021
DYT-TOR1A or DYT1 early-onset generalized dystonia is an inherited movement disorder characterized by sustained muscle contractions causing twisting, repetitive movements, or abnormal postures.
Fumiaki Yokoi, Mai Tu Dang, Lin Zhang, Kelly M. Dexter, Iakov Efimenko, Shiv Krishnaswamy, Matthew Villanueva, Carly I. Misztal, Malinda Gerard, Patrick Lynch, Yuqing Li   +10 more
doaj  

Roles of Phosphorylation-dependent and -independent Mechanisms in the Regulation of M1 Muscarinic Acetylcholine Receptors by G Protein-coupled Receptor Kinase 2 in Hippocampal Neurons [PDF]

, 2005
Jonathon M. Willets, Stefan R. Nahorski, R. A. John Challiss   +2 more
openalex   +1 more source