Results 11 to 20 of about 29,153 (282)
Journal of Ayurveda, 2023 Introduction: Mandukaparni, being one of the medhya rasayanas, has shown remarkable therapeutic effects in the management of psychological disorders. Network pharmacology is the latest scientific collaboration where new drug actions can be established ...
T. Adarsh, Giridhar Vedantam
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Structure of the m1 Muscarinic Acetylcholine Receptor Gene and Its Promoter [PDF]
Journal of Biological Chemistry, 1997 The m1 receptor is one of five muscarinic receptors that mediate the metabotropic actions of acetylcholine in the nervous system where it is expressed predominantly in the telencephalon and autonomic ganglia. RNase protection, primer extension, and 5'-rapid amplification of cDNA ends analysis of a rat cosmid clone containing the entire m1 gene ...
S. Pepitoni, Noel J. Buckley, Ian Wood
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M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer’s disease pathology [PDF]
Brain Communications, 2020 Aggregation of amyloid beta and loss of cholinergic innervation in the brain are predominant components of Alzheimer’s disease pathology and likely underlie cognitive impairment.
J. Yi +6 more
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Journal of Pharmacological Sciences, 2016 The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
P. Tangsucharit +6 more
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Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene [PDF]
AAPS PharmSci, 2001 The gene encoding the human muscarinic receptor, type 1 (CHRM1), was genotyped from 245 samples of the Coriell Collection (Coriell Institute for Medical Research, Camden, NJ). Fifteen single nucleotide polymorphisms (SNPs) were discovered, 9 of which are located in the coding region of the receptor.
Julie L. Lucas +2 more
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Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]
Cells, 2023 Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng +2 more
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Scientific Reports, 2019 Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for glaucoma. We tested the hypothesis that the lack of a single muscarinic receptor subtype leads to age-dependent neuron reduction in the retinal ganglion cell
P. Laspas +9 more
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M1 muscarinic acetylcholine receptor in Alzheimer’s disease [PDF]
Neuroscience Bulletin, 2014 The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified.
Shangtong Jiang +6 more
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Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes [PDF]
Science, 2019 Choosing a partner G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs.
S. Maeda +4 more
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Functional Analysis of Transmembrane Domain 2 of the M1 Muscarinic Acetylcholine Receptor [PDF]
Journal of Biological Chemistry, 2007 Ala substitution scanning mutagenesis has been used to probe the functional role of amino acids in transmembrane (TM) domain 2 of the M1 muscarinic acetylcholine receptor, and of the highly conserved Asn43 in TM1. The mutation of Asn43, Asn61, and Leu64 caused an enhanced ACh affinity phenotype. Interpreted using a rhodopsin-based homology model, these
Mark S. Bee, Edward C. Hulme
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