Results 211 to 220 of about 15,706 (256)

An in vivo biosensor for neurotransmitter release and In situ receptor activity : acetylcholine and the M1 muscarinic receptor

, 2009
Lee Schroeder
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Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors

RT Betterton (21865877), LM Broad (7812080), K Tsaneva-Atanasova (21846731), JR Mellor (21846734)   +3 more
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Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model

Dalla Porta L, Fousek J, Destexhe A, Sanchez-Vives MV.   +3 more
europepmc   +1 more source

Effects of Biperiden (Cholinergic Muscarinic m1/m4 Receptor Antagonist) on Craving Nicotine: A Proof-Of-Concept Clinical Study.

Eur Addict Res
Rosa Ciutti GL, Bezerra AG, Takahashi S, Jardim JR, Vicente R, Galduróz JCF, Palombo P.   +6 more
europepmc   +1 more source

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Autoantibodies against M1 muscarinic acetylcholine receptor in myasthenic disorders

European Journal of Neurology, 2007
The Lambert–Eaton myasthenic syndrome (LEMS), often associated with small‐cell lung carcinoma (SCLC), is a disorder of acetylcholine (ACh) release from motor nerve terminals. In most patients, it is caused by autoantibodies against the P/Q‐type voltage‐gated calcium channels (VGCC) that trigger ACh release. However, these antibodies are not detected in
M, Takamori, M, Motomura, T, Fukudome, H, Yoshikawa   +3 more
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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

Nature Neuroscience, 2002
Blockade of cholinergic neurotransmission by muscarinic receptor antagonists produces profound deficits in attention and memory. However, the antagonists used in previous studies bind to more than one of the five muscarinic receptor subtypes. Here we examined memory in mice with a null mutation of the gene coding the M1 receptor, the most densely ...
Stephan G, Anagnostaras, Geoffrey G, Murphy, Susan E, Hamilton, Scott L, Mitchell, Nancy P, Rahnama, Neil M, Nathanson, Alcino J, Silva   +6 more
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Targeting the M1 muscarinic acetylcholine receptor in neurodegeneration

2023
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and to date, no disease-modifying treatments exist. The M1 muscarinic acetylcholine receptor (mAChR) is an established therapeutic target for the symptomatic treatment of AD, and drugs activating the M1 mAChR have been shown to improve cognitive decline and behavioural symptoms in ...
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M1 Muscarinic Acetylcholine Receptor Agonism Alters Sleep without Affecting Memory Consolidation

Journal of Cognitive Neuroscience, 2006
Abstract Preclinical studies have implicated cholinergic neurotransmission, specifically M1 muscarinic acetylcholine receptor (mAChR) activation, in sleep-associated memory consolidation. In the present study, we investigated the effects of administering the direct M1 mAChR agonist RS-86 on pre-post sleep memory consolidation.
Nissen, Christoph, Power, Ann E., Nofzinger, Eric A., Feige, Bernd, Voderholzer, Ulrich, Klöpfer, Corinna, Waldheim, Bernhard, Radosa, Marc Philipp, Berger, Mathias, Riemann, Dieter   +9 more
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