Results 221 to 230 of about 29,153 (282)

Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities. [PDF]

Mol Neurodegener
Huang Z, Zhang Y, Zou P, Zong X, Zhang Q.   +4 more
europepmc   +1 more source

Co-stimulation of muscarinic M1 and M4 acetylcholine receptors prevents later cocaine reinforcement in male and female mice, but not place-conditioning

Abhishek Shankar Balakrishnan, Lærke Bornø Engelhardt Johansen, Craig W. Lindsley, P. Jeffrey Conn, Morgane Thomsen   +4 more
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Developing muscarinic receptor M1 classification models utilizing transfer learning and generative AI techniques. [PDF]

Sci Rep
Dey S, Wallqvist A, AbdulHameed MDM.
europepmc   +1 more source

A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice

Khaled S. Abd‐Elrahman, Tash‐Lynn L. Colson, Shaarika Sarasija, Stephen S. G. Ferguson   +3 more
openalex   +1 more source

The potential of repurposing clemastine to promote remyelination. [PDF]

Front Cell Neurosci
Yamazaki R, Ohno N.
europepmc   +1 more source

Weight Gain With Advancing Age Is Controlled by the Muscarinic Acetylcholine Receptor M4 in Male Mice.

Endocrinology
Takahashi T, Takase Y, Shiraishi A, Matsubara S, Watanabe T, Kirimoto S, Yamagaki T, Osawa M.   +7 more
europepmc   +1 more source

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M1 muscarinic acetylcholine receptor‐mediated inhibition of GABA release from striatal medium spiny neurons onto cholinergic interneurons

European Journal of Neuroscience, 2020
Acetylcholine (ACh) modulates neurotransmitter release in the central nervous system. Although GABAergic transmission onto the striatal cholinergic interneurons (ChIN) is modulated by dopamine receptors, cholinergic modulation of the same synapse is ...
Etsuko Suzuki, T. Momiyama
semanticscholar   +1 more source

Involvement of M1-muscarinic receptors in the excitation of neocortical neurones by acetylcholine

Neuropharmacology, 1987
The technique of microelectrophoresis was used to investigate the cholinoceptor pharmacology of spontaneously active single neurones in the parietal cortex of the rat. Acetylcholine, carbachol and the selective M1-muscarinic receptor agonist, McN-A-343, were each potent excitants (rank order of apparent potency: carbachol greater than acetylcholine ...
C. M. Bradshaw, R.D. Sheridan, E. Szabadi   +2 more
openaire   +3 more sources

Autoantibodies against M1 muscarinic acetylcholine receptor in myasthenic disorders

European Journal of Neurology, 2007
The Lambert–Eaton myasthenic syndrome (LEMS), often associated with small‐cell lung carcinoma (SCLC), is a disorder of acetylcholine (ACh) release from motor nerve terminals. In most patients, it is caused by autoantibodies against the P/Q‐type voltage‐gated calcium channels (VGCC) that trigger ACh release. However, these antibodies are not detected in
Hiroaki Yoshikawa, Takayasu Fukudome, Masakatsu Motomura, Masaharu Takamori   +3 more
openaire   +3 more sources