Results 221 to 230 of about 15,706 (256)
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Toward activated homology models of the human M1 muscarinic acetylcholine receptor
Journal of Molecular Graphics and Modelling, 2014Structure-based virtual screening offers a good opportunity for the discovery of selective M1 muscarinic acetylcholine receptor (mAChR) agonists for the treatment of Alzheimer's disease. However, no 3-D structure of an M1 mAChR is yet available and the homology models that have been previously reported are only able to identify antagonists in virtual ...
Sek Peng, Chin +4 more
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Scanning Mutagenesis Studies of the M 1 Muscarinic Acetylcholine Receptor
Receptors and Channels, 2003Following the solution of the structure of bovine rhodopsin by X-ray crystallography, it has been possible to build an improved homology model of the M(1) muscarinic acetylcholine receptor. This has been used to interpret the outcome of an extensive series of scanning and point mutagenesis studies on the transmembrane domain of the receptor.
E C, Hulme, Z L, Lu, M S, Bee
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Excitatory effect of M1 muscarinic acetylcholine receptor on automaticity of mouse heart
Archives of Pharmacal Research, 2005We have investigated the effects of relatively high concentration of carbachol (CCh), an agonist of muscarinic acetylcholine receptor (mAChR), on cardiac automaticity in mouse heart. Action potentials from automatically beating right atria of mice were measured with conventional microelectrodes.
Sun-Hee, Woo +3 more
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M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation
Neuroscience Letters, 2012A prime culprit in the pathogenesis of Alzheimer's disease (AD) is overproduction/aggregation of β-amyloid (Aβ), which is derived from β-Amyloid Precursor Protein through sequential cleavages by β-site APP cleaving protein 1 (BACE1) and γ-secretase. The level/activity of BACE1 is elevated in sporadic AD and identification of proteins that affect BACE1 ...
Jiang, Shangtong +5 more
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Characterising the M1 muscarinic acetylcholine receptor in the gastrointestinal tract.
2023The M1 receptor is a protein found in the brain and is heavily implicated in memory and cognition. Drugs targeted at this protein can also cause diarrhoea, but the precise mechanism of this gastrointestinal effect is unknown. This thesis aimed to understand how the M1 receptor affects gastrointestinal function by using compounds that specifically ...
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International Journal of Cardiology, 1999
Isolated congenital heart block may be associated with primary Sjögren syndrome. In this work we describe circulating antibodies in the sera of primary Sjögren syndrome patients that are able to interact with neonatal myocardium by activating muscarinic acetylcholine receptors of M1 subtype.
E, Borda +4 more
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Isolated congenital heart block may be associated with primary Sjögren syndrome. In this work we describe circulating antibodies in the sera of primary Sjögren syndrome patients that are able to interact with neonatal myocardium by activating muscarinic acetylcholine receptors of M1 subtype.
E, Borda +4 more
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Scanning mutagenesis of transmembrane domain 3 of the m1 muscarinic acetylcholine receptor
Journal of Physiology-Paris, 1998Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor has revealed a highly-differentiated alpha-helical structure. Lipid-facing residues are distinguished from a patch of residues which selectively stabilise the ground state of the receptor, and from a band of amino acids extending the full length of the helix ...
E C, Hulme, Z L, Lu
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M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.
Journal of molecular neuroscience : MN, 2007The five muscarinic acetylcholine receptors (M1-M5 mAChRs) mediate a very large number of important physiological functions (Caulfield, 1993; Caulfield and Birdsall, 1998; Wess, 2004). Because of the lack of small molecule ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues or cell types express two or more
Dinesh, Gautam +7 more
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Molecular and Cellular Neuroscience, 2013
Muscarinic receptors (mAChRs) control several neuronal functions and are widely expressed in the central nervous system (CNS): M1 subtype represents the predominant mAChR in the CNS. Previously, we showed that antioxidant enzyme Cu-Zn superoxide dismutase (SOD1) is secreted by many cellular lines and specifically interacts with cell surface membrane of
DAMIANO, Simona +5 more
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Muscarinic receptors (mAChRs) control several neuronal functions and are widely expressed in the central nervous system (CNS): M1 subtype represents the predominant mAChR in the CNS. Previously, we showed that antioxidant enzyme Cu-Zn superoxide dismutase (SOD1) is secreted by many cellular lines and specifically interacts with cell surface membrane of
DAMIANO, Simona +5 more
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The Journal of Pharmacology and Experimental Therapeutics, 1995
Irsogladine, an agent that protects gastric mucosa against various ulcerogenic stimuli through increasing cyclic AMP in surface mucous cells, has been reported to dose-dependently (10(-7) to 10(-5) M) facilitate gap-junctional intercellular communication (GJIC) in gastric epithelial cells.
F, Ueda, K, Ban, T, Ishima
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Irsogladine, an agent that protects gastric mucosa against various ulcerogenic stimuli through increasing cyclic AMP in surface mucous cells, has been reported to dose-dependently (10(-7) to 10(-5) M) facilitate gap-junctional intercellular communication (GJIC) in gastric epithelial cells.
F, Ueda, K, Ban, T, Ishima
openaire +2 more sources