Results 81 to 90 of about 29,153 (282)
Clinical Pharmacology in Drug Development, EarlyView.Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia +8 more
wiley +1 more source
The FASEB Journal, 2018 SUMOylation is a significant post‐translational modification (PTM) by the small ubiquitin‐related modifier (SUMO). Increasing evidence shows SUMOylation regulates GPCR signaling; however, very few GPCRs have been shown to be SUMOylation targets to date ...
Jianrong Xu +10 more
semanticscholar +1 more source
Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor. [PDF]
PLoS ONE, 2010 Xanomeline is a unique agonist of muscarinic receptors that possesses functional selectivity at the M(1) and M(4) receptor subtypes. It also exhibits wash-resistant binding to and activation of the receptor.
Marianne K O Grant +5 more
doaj +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
Novel aspects of cholinergic regulation of colonic ion transport [PDF]
, 2015 Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core +1 more source
PLoS ONE, 2022 Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex.
Ariel A Batallán Burrowes +5 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U +6 more
wiley +1 more source
Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors [PDF]
European Journal of Neuroscience, 2017 AbstractModulation of gamma oscillations is important for the processing of information and the disruption of gamma oscillations is a prominent feature of schizophrenia and Alzheimer's disease. Gamma oscillations are generated by the interaction of excitatory and inhibitory neurons where their precise frequency and amplitude are controlled by the ...
Ruth T. Betterton +3 more
openaire +5 more sources
Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation
Frontiers in Immunology, 2019 The brain regulates physiological functions integral to survival. However, the insight into brain neuronal regulation of peripheral immune function and the neuromediator systems and pathways involved remains limited. Here, utilizing selective genetic and
Kurt R. Lehner +32 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill +6 more
wiley +1 more source