Results 81 to 90 of about 29,353 (245)

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor. [PDF]

PLoS ONE, 2010
Xanomeline is a unique agonist of muscarinic receptors that possesses functional selectivity at the M(1) and M(4) receptor subtypes. It also exhibits wash-resistant binding to and activation of the receptor.
Marianne K O Grant, Meredith J Noetzel, Kayla C De Lorme, Jan Jakubík, Vladimír Doležal, Esam E El-Fakahany   +5 more
doaj   +1 more source

Novel aspects of cholinergic regulation of colonic ion transport [PDF]

, 2015
Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation

Frontiers in Immunology, 2019
The brain regulates physiological functions integral to survival. However, the insight into brain neuronal regulation of peripheral immune function and the neuromediator systems and pathways involved remains limited. Here, utilizing selective genetic and
Kurt R. Lehner, Harold A. Silverman, Harold A. Silverman, Meghan E. Addorisio, Ashbeel Roy, Ashbeel Roy, Mohammed A. Al-Onaizi, Mohammed A. Al-Onaizi, Yaakov Levine, Peder S. Olofsson, Peder S. Olofsson, Sangeeta S. Chavan, Sangeeta S. Chavan, Robert Gros, Robert Gros, Robert Gros, Neil M. Nathanson, Yousef Al-Abed, Yousef Al-Abed, Christine N. Metz, Christine N. Metz, Vania F. Prado, Vania F. Prado, Vania F. Prado, Vania F. Prado, Marco A. M. Prado, Marco A. M. Prado, Marco A. M. Prado, Marco A. M. Prado, Kevin J. Tracey, Kevin J. Tracey, Valentin A. Pavlov, Valentin A. Pavlov   +32 more
doaj   +1 more source

Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex.

PLoS ONE, 2022
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex.
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapman   +5 more
doaj   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor [PDF]

Proceedings of the National Academy of Sciences, 1998
Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of diverse tyrosine kinases. Using a stable cell line approach, we characterize the activation of PYK2, a tyrosine kinase structurally related to focal adhesion kinase, by the G protein-coupled m1 muscarinic acetylcholine receptor. We
J S, Felsch, T G, Cachero, E G, Peralta
openaire   +2 more sources

FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.

PLoS ONE, 2012
Background and objectiveMuscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention.
Danijela Markovic, Jonathan Holdich, Suleiman Al-Sabah, Rajendra Mistry, Cornelius Krasel, Martyn P Mahaut-Smith, R A John Challiss   +6 more
doaj   +1 more source

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Frontiers in Neural Circuits, 2022
The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source