Results 1 to 10 of about 27,064 (276)

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq [PDF]

Communications Biology
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham, Asuka Inoue, Jun Xu, Yang Du, Ka Young Chung   +4 more
doaj   +7 more sources

Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes [PDF]

Frontiers in Immunology, 2020
Background and Aims: In primary biliary cholangitis (PBC), antibodies to a peptide of the muscarinic acetylcholine receptor 3 (mAChR3) have been described.
Christian Mayer, Beate Preuss, Julia Grottenthaler, Christoph Berg, Reinhild Klein   +4 more
doaj   +5 more sources

The Role of Muscarinic Acetylcholine Receptor M₃ in Cardiovascular Diseases. [PDF]

Int J Mol Sci
The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs).
Liu X, Yu Y, Zhang H, Zhang M, Liu Y.
europepmc   +4 more sources

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +5 more sources

Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor [PDF]

Frontiers in Pharmacology, 2019
Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults.
Lihui Zhao, Lihui Zhao, Tingting Chen, Tingting Chen, Pengzhou Hang, Pengzhou Hang, Wen Li, Wen Li, Jing Guo, Jing Guo, Yang Pan, Yang Pan, Jingjing Du, Jingjing Du, Yuyang Zheng, Yuyang Zheng, Zhimin Du, Zhimin Du, Zhimin Du   +18 more
doaj   +3 more sources

Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. [PDF]

Nat Commun, 2015
The olfactory system in rodents serves a critical function in social, reproductive and survival behaviours. Processing of chemosensory signals in the brain is dynamically regulated in part by an animal’s physiological state.
Jiang Y, Li YR, Tian H, Ma M, Matsunami H.   +4 more
europepmc   +5 more sources

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser, Katharina Becker, Evi Kostenis, Gabriele König, Cornelius Krasel, Peter Kolb, Moritz Bünemann   +6 more
doaj   +3 more sources

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +3 more sources

Investigation of Muscarinic Acetylcholine Receptor M₃ Activation in Atomistic Detail: A Chemist's Viewpoint. [PDF]

ChemMedChem
We analyzed the precise ligand:receptor interactions required for activation of the muscarinic acetylcholine receptor M3, a prototypical G protein‐coupled receptor and potential diabetes target.
Drabek M, Emmerich R, Djulic N, Bünemann M, Schlitzer M, Kolb P.   +5 more
europepmc   +2 more sources

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]

, 2010
Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +4 more sources