Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq [PDF]
Communications BiologyMuscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham +4 more
doaj +6 more sources
Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes [PDF]
Frontiers in Immunology, 2020 Background and Aims: In primary biliary cholangitis (PBC), antibodies to a peptide of the muscarinic acetylcholine receptor 3 (mAChR3) have been described.
Christian Mayer +4 more
doaj +8 more sources
Investigation of Muscarinic Acetylcholine Receptor M<sub>3</sub> Activation in Atomistic Detail: A Chemist's Viewpoint. [PDF]
ChemMedChemThe activation of the muscarinic acetylcholine receptor M3, a prototypical G protein‐coupled receptor, is studied by systematically tailoring ligands. Molecules as small as CH3NH2 and as big as trimethyl(pent‐2‐yn‐1‐yl)azanium are synthesized and pharmacologically evaluated, yielding insights into ligand‐induced receptor activation in almost atomistic ...
Drabek M +5 more
europepmc +5 more sources
Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype
Journal of Pharmacological Sciences, 2004 Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi +5 more
doaj +6 more sources
Exploring the Antidiarrheal Properties of Papaya Leaf: Insights In Vivo Study in Mice-Model and In Silico Analysis at M3 Muscarinic Acetylcholine Receptor Interaction [PDF]
ScientificaDiarrhea caused by gut motility involves 5-HT3 serotonin receptor (5-HT3R) antagonist, M3 muscarinic acetylcholine receptor (M3-AchR), and H1 histamine receptor (H1R) via their respective agonist.
Nyi Mekar Saptarini +2 more
doaj +3 more sources
Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]
Cells, 2023 Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng +2 more
doaj +2 more sources
Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens [PDF]
AnimalsPhotoperiods are crucial environmental factors in the growth and health of modern intensive broiler chicken production. To date, the effects of different photoperiods on glucose metabolism, acetylcholine (ACh), and its relative acetylcholine receptor ...
Miao Yu +4 more
doaj +2 more sources
Herbal Amara extract induces gastric fundus relaxation via inhibition of the M2 muscarinic receptor. [PDF]
Neurogastroenterol MotilThis preclinical study demonstrates the relaxant effect of Amara herbal extract (containing nine different plant extracts) on fundus smooth muscles dissected from guinea pigs. This relaxant effect occurs via inhibition of M2 muscarinic receptor activity.
Piqué-Borràs MR, Röhrl J, Künstle G.
europepmc +2 more sources
Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives [PDF]
Frontiers in Molecular BiosciencesParasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim +4 more
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Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
Andrology, Volume 11, Issue 2, Page 379-398, February 2023., 2023 Abstract Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million.
Ankit Desai +4 more
wiley +1 more source