Results 1 to 10 of about 13,057 (254)

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq. [PDF]

Commun Biol
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Ham D, Inoue A, Xu J, Du Y, Chung KY.
europepmc   +6 more sources

Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes. [PDF]

Front Immunol, 2020
Background and Aims: In primary biliary cholangitis (PBC), antibodies to a peptide of the muscarinic acetylcholine receptor 3 (mAChR3) have been described.
Mayer C, Preuss B, Grottenthaler J, Berg C, Klein R.   +4 more
europepmc   +7 more sources

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +7 more sources

Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]

Cells, 2023
Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng, Jürgen Wess, Christian Alzheimer   +2 more
openalex   +3 more sources

Downstream Signaling of Muscarinic M₄ Receptors Is Regulated by Receptor Density and Cellular Environment. [PDF]

Pharmacol Res Perspect
ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Merz M, Playle C, Palchaudhuri M, Hucke O, Gross U, Ursu D.   +5 more
europepmc   +2 more sources

Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens. [PDF]

Animals (Basel)
Photoperiods are crucial environmental factors in the growth and health of modern intensive broiler chicken production. To date, the effects of different photoperiods on glucose metabolism, acetylcholine (ACh), and its relative acetylcholine receptor ...
Yu M, Xu M, Wang G, Feng J, Zhang M.
europepmc   +2 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +2 more sources

Exploring the Antidiarrheal Properties of Papaya Leaf: Insights In Vivo Study in Mice‐Model and In Silico Analysis at M3 Muscarinic Acetylcholine Receptor Interaction

Scientifica
Diarrhea caused by gut motility involves 5-HT3 serotonin receptor (5-HT3R) antagonist, M3 muscarinic acetylcholine receptor (M3-AchR), and H1 histamine receptor (H1R) via their respective agonist.
Nyi Mekar Saptarini, Faruk Jayanto Kelutur, Mary Jho-Anne T. Corpuz   +2 more
openalex   +2 more sources

Reduced M3 muscarinic acetylcholine receptor expression in gestational diabetes mellitus: implications for placental dysfunction and vascular regulation

The Journal of Maternal-Fetal & Neonatal Medicine
Objectives Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder affecting pregnancy, leading to significant maternal and fetal complications.
Süleyman Cemil Oğlak, Fırat Aşır, Tuğcan Korak, Ayşegül Aşır, Emine Zeynep Yılmaz, Elif Ağaçayak   +5 more
openalex   +3 more sources

Effect of Eugenol on Detrusor Muscle: Potential for Overactive Bladder Treatment. [PDF]

Int Neurourol J
Purpose This investigation was conducted to elucidate the effects of eugenol on bladder contractility through experimental and in silico approaches. Methods To assess the impact of eugenol on muscular contractility, longitudinal strips of bladder tissue,
Araújo MC, Pereira-Gonçalves Á, Cardeal Dos Santos AN, Freire JEDC, Peireira-de-Morais L, Henrique-Félix FS, Sousa-Júlio NCC, Leal-Cardoso JH, Coelho-de-Souza AN.   +8 more
europepmc   +2 more sources