Results 91 to 100 of about 13,362 (255)

Acetylcholine Receptor Stimulation Activates Protein Kinase C Mediated Internalization of the Dopamine Transporter

Frontiers in Cellular Neuroscience, 2021
The dopamine transporter (DAT) clears neurotransmitters from the extracellular space and serves as an important regulator of signal amplitude and duration at sites of dopamine release. Several different intracellular signaling pathways have been observed
Suzanne M. Underhill, Susan G. Amara
doaj   +1 more source

Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation and resuscitation. While the effect(s) of opioids on central rhythm‐generating circuits are well documented, the mechanisms ...
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Nicholas J. Burgraff   +3 more
wiley   +1 more source

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.

PLoS Pathogens, 2015
Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus ...
Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Jane Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F Cunningham, Frank Brombacher, Murray E Selkirk, William G C Horsnell   +11 more
doaj   +1 more source

Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Because the prevalence of age-related cardiac impairment increases as the human lifespan increases, it is important to combat the effects of aging.
Shu Wang, Yanan Jiang, Jingling Chen, Changliang Dai, Dandan Liu, Wei Pan, Lijuan Wang, Moyondafoluwa Blessing Fasae, Lihua Sun, Lanfeng  Wang, Yan Liu   +10 more
doaj   +1 more source

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts

Brain, Behavior, & Immunity - Health, 2020
Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist   +5 more
doaj   +1 more source

Evaluation of the gastrointestinal anti-motility effect of Anacardium occidentale stem bark extract: A mechanistic study of antidiarrheal activity

Journal of Pharmaceutical Analysis, 2021
Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It is a huge public health concern that requires better alternatives to current drugs.
Blessing O. Omolaso, Francis S. Oluwole, Olugbenga A. Odukanmi, Julius K. Adesanwo, Ahmed A. Ishola, Kayode E. Adewole   +5 more
doaj   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor

Frontiers in Pharmacology, 2019
Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults.
Lihui Zhao, Lihui Zhao, Tingting Chen, Tingting Chen, Pengzhou Hang, Pengzhou Hang, Wen Li, Wen Li, Jing Guo, Jing Guo, Yang Pan, Yang Pan, Jingjing Du, Jingjing Du, Yuyang Zheng, Yuyang Zheng, Zhimin Du, Zhimin Du, Zhimin Du   +18 more
doaj   +1 more source

Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits

The Journal of Physiology, Volume 603, Issue 19, Page 5723-5749, October 1, 2025.
Abstract figure legend During colonic motor complex activity, enteric glia play a pivotal role by releasing the S100 calcium‐binding protein B (S100B). This gliotransmitter has both intra‐ and extracellular functions, including the regulation of neuronal and glial excitability within the enteric nervous system.
Beatriz Thomasi, Rafaella Lavalle, Jonathon L. McClain, Julia Jamka, Luisa Seguella, Brian D. Gulbransen   +5 more
wiley   +1 more source