Results 121 to 130 of about 13,431 (223)

Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

The Journal of Clinical Hypertension
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP).
Xi Zhang, Shi Yao, Peng Bao, Mingfei Du, Guilin Hu, Chao Chu, Dan Wang, Chen Chen, Qiong Ma, Hao Jia, Yue Sun, Yu Yan, Yueyuan Liao, Zejiaxin Niu, Ziyue Man, Lan Wang, Weihua Gao, Hao Li, Jie Zhang, Wenjing Luo, Xin Wang, Yang Wang, Jianjun Mu   +22 more
doaj   +1 more source

Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives

Frontiers in Molecular Biosciences
Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim, Mohamed M. Ibrahim, Mohamed M. Ibrahim, Monica M. Jablonski, Monica M. Jablonski   +4 more
doaj   +1 more source

Signaling Bias and Antagonism of Pilocarpine for M3 Muscarinic Acetylcholine Receptor

The FASEB Journal, 2018
Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth since the 19 th century and classified as either a full or partial muscarinic agonist. Here, we report several unexpected results pertaining to its interaction with its main therapeutic target ‐ muscarinic M3 receptor ...
Alexey N. Pronin, Kelly Wang, Vladlen Z. Slepak   +2 more
openaire   +1 more source

Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjögren Syndrome [PDF]

, 2014
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors of M3 in salivary gland and M1 ...
Borda, Enri Santiago, Reina, Silvia Lorena   +1 more
core   +1 more source

Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2018
Nerve growth factor (NGF) plays an important role in airway hyper-responsiveness (AHR). In this study, we aimed at investigating the effect of NGF inhibition on AHR and other asthma phenotypes in a mouse model of asthma.
Jinhong Wu, Bing Chen, Wenxian Li, Yanan Xiao   +3 more
doaj  

Molecular mechanisms for fetal cardiac arrhythmia in intrahepatic cholestasis of pregnancy

, 2010
Intrahepatic cholestasis in pregnancy (ICP) is characterized by raised serum bile acids which can cause fetal complications, including preterm labour and intrauterine death. The fetal death in ICP is not well understood. In this thesis, the mechanisms of
Sheikh Abdul Kadir, Siti Hamimah, Sheikh Abdul Kadir, Siti Hamimah   +1 more
core   +1 more source

The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families

Molecular Pharmacology
The M3 muscarinic acetylcholine receptor (M3R) is a G protein-coupled receptor (GPCR) that regulates important physiologic processes, including vascular tone, bronchoconstriction, and insulin secretion. It is expressed on a wide variety of cell types, including pancreatic beta, smooth muscle, neuronal, and immune cells.
Jeffrey S. Smith, Ari S. Hilibrand, Meredith A. Skiba, Andrew N. Dates, Victor G. Calvillo-Miranda, Andrew C. Kruse   +5 more
openaire   +2 more sources

Exploring the Antidiarrheal Properties of Papaya Leaf: Insights In Vivo Study in Mice-Model and In Silico Analysis at M3 Muscarinic Acetylcholine Receptor Interaction

Scientifica
Diarrhea caused by gut motility involves 5-HT3 serotonin receptor (5-HT3R) antagonist, M3 muscarinic acetylcholine receptor (M3-AchR), and H1 histamine receptor (H1R) via their respective agonist.
Nyi Mekar Saptarini, Faruk Jayanto Kelutur, Mary Jho-Anne Tolentino Corpuz   +2 more
doaj   +1 more source

Investigation of M3 muscarinic acetylcholine receptor expression in placentas of smoking women

Perinatal Journal
Objective: This study examined M3 muscarinic acetylcholine receptor expression in placentas of women who smoked during pregnancy and explored the affected signaling pathways via network and functional annotation analyses. Methods: Placenta samples from 45 control subjects and 45 individuals who smoked during pregnancy were fixed in zinc-formalin and em-
Esma Yıldırım, Gül Ebru Aydeniz Acar, Zeynep Türe, Ayşegül Aşır, Fırat Aşır, Tuğcan Korak, Serhat Ege   +6 more
openaire   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source