Results 121 to 130 of about 13,362 (255)

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Cancer Cell International, 2018
Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis.
Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu, Bingyuan Zhang   +9 more
doaj   +1 more source

Chronic exposure to the anti-M3 muscarinic acetylcholine receptor autoantibody in pemphigus vulgaris contributes to disease pathophysiology [PDF]

, 2022
Alex I. Chernyavsky, Mykhailo M. Khylynskyi, Krupa G. Patel, Sergei A. Grando   +3 more
openalex   +1 more source

Molecular mechanisms for fetal cardiac arrhythmia in intrahepatic cholestasis of pregnancy

, 2010
Intrahepatic cholestasis in pregnancy (ICP) is characterized by raised serum bile acids which can cause fetal complications, including preterm labour and intrauterine death. The fetal death in ICP is not well understood. In this thesis, the mechanisms of
Sheikh Abdul Kadir, Siti Hamimah, Sheikh Abdul Kadir, Siti Hamimah   +1 more
core   +1 more source

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors [PDF]

, 2018
Positive allosteric modulators (PAMs) that target the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer's disease and schizophrenia.
Andrew B. Tobin, Arthur Christopoulos, Arthur Spathis, Ben Capuano, Celine Valant, Davoren, Ehlert, Ehlert, Elham Khajehali, Emma T. van der Westhuizen, Furchgott, Manuela Jörg, Mistry, Patrick M. Sexton, Peter J. Scammells, Shailesh N. Mistry   +15 more
core   +2 more sources

Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment? [PDF]

Int J Mol Sci, 2023
Lobbes LA, Schütze MA, Droeser R, Arndt M, Pozios I, Lauscher JC, Hering NA, Weixler B.   +7 more
europepmc   +1 more source

Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

The Journal of Clinical Hypertension
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP).
Xi Zhang, Shi Yao, Peng Bao, Mingfei Du, Guilin Hu, Chao Chu, Dan Wang, Chen Chen, Qiong Ma, Hao Jia, Yue Sun, Yu Yan, Yueyuan Liao, Zejiaxin Niu, Ziyue Man, Lan Wang, Weihua Gao, Hao Li, Jie Zhang, Wenjing Luo, Xin Wang, Yang Wang, Jianjun Mu   +22 more
doaj   +1 more source

Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives

Frontiers in Molecular Biosciences
Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim, Mohamed M. Ibrahim, Mohamed M. Ibrahim, Monica M. Jablonski, Monica M. Jablonski   +4 more
doaj   +1 more source

Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjögren Syndrome [PDF]

, 2014
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors of M3 in salivary gland and M1 ...
Borda, Enri Santiago, Reina, Silvia Lorena   +1 more
core   +1 more source

P2Y2 Purinergic and M3 Muscarinic Acetylcholine Receptors Activate Different Phospholipase C-β Isoforms That Are Uniquely Susceptible to Protein Kinase C-dependent Phosphorylation and Inactivation [PDF]

, 2000
Derek Strassheim, Carol L. Williams
openalex   +1 more source

Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome [PDF]

, 2017
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS).
Borda, Enri Santiago, Ganzinelli, Sabrina Belen, González Arana, Roberto, Pisoni, Cecilia, Reina, Silvia Lorena   +4 more
core   +1 more source