Results 11 to 20 of about 28,480 (301)

Structure and dynamics of the M3 muscarinic acetylcholine receptor [PDF]

Nature, 2012
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (
Andrew C. Kruse, Jianxin Hu, Albert C. Pan, Daniel H. Arlow, Daniel M. Rosenbaum, Erica Rosemond, Hillary F. Green, Tong Liu, Pil Seok Chae, Ron O. Dror, David E. Shaw, William I. Weis, Jürgen Wess, Brian K. Kobilka   +13 more
semanticscholar   +5 more sources

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +2 more sources

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]

, 2010
Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +4 more sources

Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor

Frontiers in Pharmacology, 2019
Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults.
Lihui Zhao, Lihui Zhao, Tingting Chen, Tingting Chen, Pengzhou Hang, Pengzhou Hang, Wen Li, Wen Li, Jing Guo, Jing Guo, Yang Pan, Yang Pan, Jingjing Du, Jingjing Du, Yuyang Zheng, Yuyang Zheng, Zhimin Du, Zhimin Du, Zhimin Du   +18 more
doaj   +2 more sources

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes.
Hongtao Liu, J. Hofmann, I. Fish, B. Schaake, K. Eitel, A. Bartuschat, J. Kaindl, H. Rampp, A. Banerjee, H. Hübner, M. Clark, S. Vincent, J. Fisher, M. Heinrich, K. Hirata, Xiangyu Liu, R. Sunahara, B. Shoichet, B. Kobilka, P. Gmeiner   +19 more
semanticscholar   +6 more sources

Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens [PDF]

Animals
Photoperiods are crucial environmental factors in the growth and health of modern intensive broiler chicken production. To date, the effects of different photoperiods on glucose metabolism, acetylcholine (ACh), and its relative acetylcholine receptor ...
Miao Yu, Mengjie Xu, Guangju Wang, Jinghai Feng, Minhong Zhang   +4 more
doaj   +2 more sources

Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer.

Oncology Letters, 2016
The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer.
Liqiang Guo, Yuqiang Liu, Zhibo Ding, Wendong Sun, Mingzhen Yuan   +4 more
semanticscholar   +5 more sources

Acetylcholine-treated murine dendritic cells promote inflammatory lung injury. [PDF]

PLoS ONE, 2019
In recent years a non-neuronal cholinergic system has been described in immune cells, which is often usually activated during the course of inflammatory processes. To date, it is known that Acetylcholine (ACh), a neurotransmitter extensively expressed in
Soledad Gori, Julieta Alcain, Silvia Vanzulli, Mariela A Moreno Ayala, Marianela Candolfi, Carolina Jancic, Jorge Geffner, Mónica Vermeulen, Gabriela Salamone   +8 more
doaj   +2 more sources

M3 muscarinic acetylcholine receptor reactive Th17 cells in primary Sjögren's syndrome. [PDF]

JCI Insight, 2020
M3 muscarinic acetylcholine receptor (M3R) is one of the autoantigens associated with Sjögren's syndrome (SS) and is localized in exocrine glands where disease specific inflammation occurs. The inflammatory lesion is characterized by infiltration of CD4+
S. Abe, H. Tsuboi, Hanae Kudo, H. Asashima, Yuko Ono, F. Honda, Hiroyuki Takahashi, Mizuki Yagishita, Shinya Hagiwara, Y. Kondo, I. Matsumoto, T. Sumida   +11 more
semanticscholar   +4 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +2 more sources