Results 11 to 20 of about 13,057 (254)

The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation [PDF]

Journal of Investigative Dermatology, 2022
The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine. Patients with the autoimmune blistering disease pemphigus develop autoantibodies to M3 muscarinic acetylcholine receptor and show alterations in keratinocyte adhesion ...
Junyan Duan, Charles Grando, Shuman Liu, Alex I. Chernyavsky, Jefferson K. Chen, Bogi Andersen, Sergei A. Grando   +6 more
core   +8 more sources

Acetylcholine-treated murine dendritic cells promote inflammatory lung injury. [PDF]

PLoS ONE, 2019
In recent years a non-neuronal cholinergic system has been described in immune cells, which is often usually activated during the course of inflammatory processes. To date, it is known that Acetylcholine (ACh), a neurotransmitter extensively expressed in
Soledad Gori, Julieta Alcain, Silvia Vanzulli, Mariela A Moreno Ayala, Marianela Candolfi, Carolina Jancic, Jorge Geffner, Mónica Vermeulen, Gabriela Salamone   +8 more
doaj   +2 more sources

Investigation of Muscarinic Acetylcholine Receptor M₃ Activation in Atomistic Detail: A Chemist's Viewpoint. [PDF]

ChemMedChem
Drabek M, Emmerich R, Djulic N, Bünemann M, Schlitzer M, Kolb P.   +5 more
europepmc   +3 more sources

The Role of Muscarinic Acetylcholine Receptor M₃ in Cardiovascular Diseases. [PDF]

Int J Mol Sci
The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs).
Liu X, Yu Y, Zhang H, Zhang M, Liu Y.
europepmc   +3 more sources

Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics [PDF]

British Journal of Pharmacology, 2001
Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. We expressed receptors in Xenopus oocytes.
Markus W. Hollmann, Carsten H. Ritter, Philipp Henle, Manuela De Klaver, Ganesan L. Kamatchi, Marcel E. Durieux   +5 more
openalex   +4 more sources

Ligand Regulation of the Quaternary Organization of Cell Surface M3 Muscarinic Acetylcholine Receptors Analyzed by Fluorescence Resonance Energy Transfer (FRET) Imaging and Homogeneous Time-resolved FRET [PDF]

, 2010
Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Elisa Alvarez‐Curto, Richard J. Ward, John D. Pediani, Graeme Milligan   +3 more
openalex   +5 more sources

Anti-M3 muscarinic acetylcholine receptor antibodies and Sjögren's syndrome

Japanese Journal of Clinical Immunology, 2013
Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. It is characterized by lymphocytic infiltration into exocrine glands, leading to dry mouth and eyes. A number of auto-antibodies are detected in patients with SS. However, no SS-specific pathologic auto-antibodies have yet been found in
Hiroto Tsuboi, Mana Iizuka, Hiromitsu Asashima, Takayuki Sumida   +3 more
openalex   +4 more sources

Structure and dynamics of the M3 muscarinic acetylcholine receptor [PDF]

Nature, 2012
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence homology, they show pronounced differences in G-protein ...
Andrew C. Kruse, Jianxin Hu, Albert C. Pan, Daniel H. Arlow, Daniel M. Rosenbaum, Erica Rosemond, Hillary F. Green, Tong Liu, Pil Seok Chae, Ron O. Dror, David E. Shaw, William I. Weis, Jürgen Wess, Brian K. Kobilka   +13 more
openalex   +4 more sources

Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor. [PDF]

J Biol Chem
Reyes-Ruiz JM, Chernyavsky A, Grando SA, Glabe C.   +3 more
europepmc   +2 more sources

Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor. [PDF]

The EMBO Journal, 1993
The five muscarinic acetylcholine receptor (mAChR) subtypes, termed m1-m5, transduce agonist signals across the plasma membrane by activating guanine nucleotide binding (G) proteins. The large cytoplasmic domain joining the fifth and sixth transmembrane segments of mAChRs plays a critical role in controlling the specificity of G protein coupling.
Maya T. Kunkel, E G Peralta
openalex   +4 more sources