Results 11 to 20 of about 27,064 (276)

Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer

Oncology Letters, 2015
The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer.
Liqiang Guo, Yuqiang Liu, Zhibo Ding, Wendong Sun, Mingzhen Yuan   +4 more
semanticscholar   +6 more sources

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of ¹⁸F-Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3. [PDF]

ChemMedChem
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Herrera-Rueda MA, Boateng MA, Wuest M, West FG, Wuest F.   +4 more
europepmc   +4 more sources

RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren's syndrome-like sialadenitis [PDF]

Clinical and Experimental Immunology, 2016
Summary We showed recently that M3 muscarinic acetylcholine receptor (M3R)-reactive CD3+ T cells play a pathogenic role in the development of murine autoimmune sialadenitis (MIS), which mimics Sjögren's syndrome (SS). The aim of this study was to determine the effectiveness and mechanism of action of retinoic acid-related orphan receptor-
Masahiro Tahara, Hiroto Tsuboi, Seiji Segawa, Hiromitsu Asashima, Mana Iizuka-Koga, T Hirota, Hidenori Takahashi, Yuya Kondo, M. Matsui, Isao Matsumoto, Tomokazu S. Sumida   +10 more
semanticscholar   +4 more sources

Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]

Cells, 2023
Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng, Jürgen Wess, Christian Alzheimer   +2 more
doaj   +2 more sources

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes.
Hongtao Liu, J. Hofmann, I. Fish, B. Schaake, K. Eitel, A. Bartuschat, J. Kaindl, H. Rampp, A. Banerjee, H. Hübner, M. Clark, S. Vincent, J. Fisher, M. Heinrich, K. Hirata, Xiangyu Liu, R. Sunahara, B. Shoichet, B. Kobilka, P. Gmeiner   +19 more
semanticscholar   +5 more sources

M3 muscarinic acetylcholine receptor reactive Th17 cells in primary Sjögren's syndrome. [PDF]

JCI Insight, 2020
M3 muscarinic acetylcholine receptor (M3R) is one of the autoantigens associated with Sjögren's syndrome (SS) and is localized in exocrine glands where disease specific inflammation occurs. The inflammatory lesion is characterized by infiltration of CD4+
S. Abe, H. Tsuboi, Hanae Kudo, H. Asashima, Yuko Ono, F. Honda, Hiroyuki Takahashi, Mizuki Yagishita, Shinya Hagiwara, Y. Kondo, I. Matsumoto, T. Sumida   +11 more
semanticscholar   +3 more sources

Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities [PDF]

Communications Biology
Medullary serotonergic (5-HT) neurons play a pivotal role in locomotor initiation. While these neurons receive cholinergic innervation, the functional consequences and underlying mechanisms remain poorly understood. Using ePet-EYFP transgenic mice (P3–P6)
Yi Cheng, Yue Dai, Renkai Ge, Qiang Zhang   +3 more
doaj   +2 more sources

Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation [PDF]

Scientific Reports, 2017
Acetylcholine (ACh), known as a neurotransmitter, regulates the functions of numerous fundamental central and peripheral nervous system. Recently, emerging evidences indicate that ACh also plays an important role in tumorigenesis.
Huangfei Yu, Hongwei Xia, Qiulin Tang, Huanji Xu, Guoqing Wei, Ying Chen, Xinyu Dai, Qiyong Gong, Feng Bi   +8 more
openalex   +2 more sources

Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells [PDF]

Pflügers Archiv: European Journal of Physiology, 2016
Each taste bud cell (TBC) type responds to a different taste. Previously, we showed that an unidentified cell type(s) functionally expresses a muscarinic acetylcholine (ACh) receptor subtype, M3, and we suggested the ACh-dependent modification of its ...
Y. Mori, Kohgaku Eguchi, K. Yoshii, Y. Ohtubo   +3 more
core   +2 more sources

Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor [PDF]

Nature, 2012
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (
A. Kruse, Jianxin Hu, Albert C. Pan, Daniel H Arlow, D. Rosenbaum, Erica Rosemond, Hillary F. Green, Tong Liu, P. S. Chae, R. Dror, D. Shaw, W. Weis, J. Wess, B. Kobilka   +13 more
semanticscholar   +3 more sources