Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]
Cells, 2023 Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng +2 more
doaj +2 more sources
Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment? [PDF]
Int J Mol Sci, 2023 Lobbes LA +7 more
europepmc +3 more sources
Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor [PDF]
Molecular Pharmacology, 2017 Alexey Pronin +2 more
openalex +2 more sources
Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells [PDF]
Pflügers Archiv: European Journal of Physiology, 2016 Each taste bud cell (TBC) type responds to a different taste. Previously, we showed that an unidentified cell type(s) functionally expresses a muscarinic acetylcholine (ACh) receptor subtype, M3, and we suggested the ACh-dependent modification of its ...
Y. Mori +3 more
semanticscholar +2 more sources
Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18 F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3 [PDF]
ChemMedChem, EarlyView.Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel Herrera-Rueda +4 more
openalex +2 more sources
Acetylcholine-treated murine dendritic cells promote inflammatory lung injury. [PDF]
PLoS ONE, 2019 In recent years a non-neuronal cholinergic system has been described in immune cells, which is often usually activated during the course of inflammatory processes. To date, it is known that Acetylcholine (ACh), a neurotransmitter extensively expressed in
Soledad Gori +8 more
doaj +2 more sources
Ligand Regulation of the Quaternary Organization of Cell Surface M3 Muscarinic Acetylcholine Receptors Analyzed by Fluorescence Resonance Energy Transfer (FRET) Imaging and Homogeneous Time-resolved FRET [PDF]
, 2010 Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Elisa Alvarez‐Curto +3 more
openalex +5 more sources
Mechanisms of Pilocarpine-Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle. [PDF]
FASEB BioadvPilocarpine activates M1 and M3 muscarinic receptors in porcine ciliary muscle, engaging calcium‐dependent phospholipase C (PLC), nitric oxide synthase (NOS), and cyclooxygenase (COX) pathways that increase prostaglandin E2 (PGE2) synthesis. Beyond nitric oxide (NO) modulation, PGE2 emerges as a key mediator linking muscarinic signaling to ciliary ...
Benozzi G +3 more
europepmc +2 more sources
RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren's syndrome-like sialadenitis [PDF]
Clinical and Experimental Immunology, 2016 Masahiro Tahara +10 more
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The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation [PDF]
Journal of Investigative Dermatology, 2022 The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine.
Junyan Duan +6 more
semanticscholar +3 more sources