Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq [PDF]
Commun BiolAbstractMuscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes. Although the structure of the M3-miniGq complex was recently published, the lack of information on the intracellular loop 3 (ICL3) of M3 and extensive modification of Gαq ...
Donghee Ham +4 more
europepmc +5 more sources
Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes [PDF]
Front Immunol, 2020 Background and Aims: In primary biliary cholangitis (PBC), antibodies to a peptide of the muscarinic acetylcholine receptor 3 (mAChR3) have been described. Since the mAChR3 is expressed on cholangiocytes and mAChR3-signaling is involved in the pathogenesis of chronic inflammatory biliary diseases, we wanted to investigate whether anti-mAChR3-antibodies
Christian T. Mayer +4 more
europepmc +6 more sources
The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation [PDF]
Journal of Investigative Dermatology, 2022 The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine.
Junyan Duan +6 more
core +8 more sources
Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype
Journal of Pharmacological Sciences, 2004 Heterologous down-regulation of histamine H(1) receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M(1) - M(5)) muscarinic acetylcholine receptors, CHO-H1/M1, CHO-H1/M2, CHO-H1/M3, CHO-H1/M4, and CHO-H1/M5 ...
Katsuhiro Miyoshi +5 more
doaj +7 more sources
The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases. [PDF]
Int J Mol SciThe muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs).
Liu X, Yu Y, Zhang H, Zhang M, Liu Y.
europepmc +3 more sources
Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics [PDF]
British Journal of Pharmacology, 2001 Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. We expressed receptors in Xenopus oocytes.
Markus W. Hollmann +5 more
openalex +4 more sources
Anti-M3 muscarinic acetylcholine receptor antibodies and Sjögren's syndrome
Japanese Journal of Clinical Immunology, 2013 Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. It is characterized by lymphocytic infiltration into exocrine glands, leading to dry mouth and eyes. A number of auto-antibodies are detected in patients with SS. However, no SS-specific pathologic auto-antibodies have yet been found in
Hiroto Tsuboi +3 more
openalex +4 more sources
Structure and dynamics of the M3 muscarinic acetylcholine receptor [PDF]
Nature, 2012 Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence homology, they show pronounced differences in G-protein ...
Andrew C. Kruse +13 more
openalex +4 more sources
Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor. [PDF]
The EMBO Journal, 1993 The five muscarinic acetylcholine receptor (mAChR) subtypes, termed m1-m5, transduce agonist signals across the plasma membrane by activating guanine nucleotide binding (G) proteins. The large cytoplasmic domain joining the fifth and sixth transmembrane segments of mAChRs plays a critical role in controlling the specificity of G protein coupling.
Maya T. Kunkel, E G Peralta
openalex +4 more sources
Ligand Regulation of the Quaternary Organization of Cell Surface M3 Muscarinic Acetylcholine Receptors Analyzed by Fluorescence Resonance Energy Transfer (FRET) Imaging and Homogeneous Time-resolved FRET [PDF]
, 2010 Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Elisa Alvarez‐Curto +3 more
openalex +5 more sources