Results 191 to 200 of about 13,431 (223)
Some of the next articles are maybe not open access.
m3 Muscarinic Acetylcholine Receptor Regulation in the Airway
American Journal of Respiratory Cell and Molecular Biology, 2002The m3 muscarinic acetylcholine receptor (m3 mAChR) plays an important role in airway function by mediating the effects of acetylcholine on multiple airway cell types. m3 mAChRs expressed in airway smooth muscle (ASM) cells promote increased ASM tension, and, therefore, airway narrowing, in response to acetylcholine release from postganglionic ...
Charlotte K, Billington, Raymond B, Penn
openaire +2 more sources
Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome
Modern Rheumatology, 2012Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies.
Takayuki, Sumida +4 more
openaire +2 more sources
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
Nature, 2001Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult primarily because of a lack of ...
M, Yamada +12 more
openaire +2 more sources
Cloning and expression of a cDNA encoding bovine muscarinic acetylcholine m3 receptor
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994A cDNA clone encoding bovine muscarinic acetylcholine m3 receptor has been isolated from a bovine brain library. Sequencing of this clone has revealed a single open reading frame encoding a protein of 590 amino acids. Comparison with known muscarinic m3 receptor sequences from other species shows a high degree of conservation (92-98% homology) in the ...
P H, Lee +3 more
openaire +2 more sources
M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines
Bioorganic & Medicinal Chemistry Letters, 2009Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M(3) muscarinic acetylcholine receptor antagonists such as 14 (pA(2)=11.0) possessing good sub-type selectivity for M(3) over M(2). The structure-activity relationships (SAR) and optimization of the bi-aryl amine series are described.
Brian, Budzik +18 more
openaire +2 more sources
Hepatobiliary & Pancreatic Diseases International, 2012
Cholangiocarcinoma, a type of malignant tumor, originates from epithelial cells of the bile duct. Perineural invasion is common path for cholangiocarcinoma metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It has been reported that muscarinic acetylcholine receptor M3 (mAChR M3) is widely expressed in digestive ...
Yu-Jie, Feng +3 more
openaire +2 more sources
Cholangiocarcinoma, a type of malignant tumor, originates from epithelial cells of the bile duct. Perineural invasion is common path for cholangiocarcinoma metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It has been reported that muscarinic acetylcholine receptor M3 (mAChR M3) is widely expressed in digestive ...
Yu-Jie, Feng +3 more
openaire +2 more sources
M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.
Journal of molecular neuroscience : MN, 2007The five muscarinic acetylcholine receptors (M1-M5 mAChRs) mediate a very large number of important physiological functions (Caulfield, 1993; Caulfield and Birdsall, 1998; Wess, 2004). Because of the lack of small molecule ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues or cell types express two or more
Dinesh, Gautam +7 more
openaire +1 more source