Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency [PDF]
Cell Metabolism, 2006 SummaryMost animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating
Cui, Yinghong +7 more
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Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis [PDF]
Arthritis Research & Therapy, 2016 BackgroundThere is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has, however, not been investigated to
J. Beckmann +4 more
semanticscholar +8 more sources
Effect of Eugenol on Detrusor Muscle: Potential for Overactive Bladder Treatment [PDF]
International Neurourology JournalPurpose This investigation was conducted to elucidate the effects of eugenol on bladder contractility through experimental and in silico approaches. Methods To assess the impact of eugenol on muscular contractility, longitudinal strips of bladder tissue,
Marília Cavalcante Araújo +8 more
doaj +2 more sources
Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases. [PDF]
Orthop SurgDue to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Xia R +7 more
europepmc +2 more sources
ScientificaDiarrhea caused by gut motility involves 5-HT3 serotonin receptor (5-HT3R) antagonist, M3 muscarinic acetylcholine receptor (M3-AchR), and H1 histamine receptor (H1R) via their respective agonist.
Nyi Mekar Saptarini +2 more
doaj +2 more sources
Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives [PDF]
Frontiers in Molecular BiosciencesParasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim +4 more
doaj +2 more sources
Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics [PDF]
British Journal of Pharmacology, 2001 Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. We expressed receptors in Xenopus oocytes.
Markus W. Hollmann +5 more
openalex +4 more sources
Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor. [PDF]
J Biol ChemReyes-Ruiz JM +3 more
europepmc +2 more sources
Anti-M3 muscarinic acetylcholine receptor antibodies and Sjögren's syndrome
Japanese Journal of Clinical Immunology, 2013 Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. It is characterized by lymphocytic infiltration into exocrine glands, leading to dry mouth and eyes. A number of auto-antibodies are detected in patients with SS. However, no SS-specific pathologic auto-antibodies have yet been found in
Hiroto Tsuboi +3 more
openalex +4 more sources
Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricular Myocytes [PDF]
Cellular Physiology and Biochemistry, 2006 Peng Yue +11 more
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