Results 21 to 30 of about 26,858 (254)

Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricular Myocytes [PDF]

Cellular Physiology and Biochemistry, 2006
Peng Yue, Yong Zhang, Zhimin Du, Jing Xiao, Zhenwei Pan, Ning Wang, Haiyan Yu, Wencai Ma, Hong Qin, Wenhui Wang, Dao‐Hong Lin, Baofeng Yang   +11 more
openalex   +2 more sources

Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor. [PDF]

J Biol Chem
Reyes-Ruiz JM, Chernyavsky A, Grando SA, Glabe C.   +3 more
europepmc   +2 more sources

General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain

Frontiers in Physiology, 2023
General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos, Dariia O. Dryn, Mariia I. Melnyk, Mariia I. Melnyk   +3 more
doaj   +1 more source

New promising agents against COPD and asthma among the amides of 1-oxo-3-phenyl-isochroman-6-carboxylic acid

Біофізичний вісник, 2023
Background: Bronchodilators, which are compounds that can relax airway smooth muscle, are perhaps the most important component of combination therapy for chronic obstructive pulmonary disease, one of the most common non-communicable diseases in the world,
Олексій Нипорко, Ольга Цимбалюк, Іван Войтешенко, Сергій Старосила, Микола Протопопов, Володимир Бджола   +5 more
doaj   +1 more source

Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease

International Journal of Molecular Sciences, 2021
The parasympathetic nervous system is critically involved in the regulation of tear secretion by activating muscarinic acetylcholine receptors. Hence, various animal models targeting parasympathetic signaling have been developed to induce dry eye disease
Aytan Musayeva, Subao Jiang, Yue Ruan, J. K. Zadeh, P. Chronopoulos, N. Pfeiffer, W. Müller, M. Ackermann, N. Xia, Huige Li, A. Gericke   +10 more
semanticscholar   +1 more source

M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p. [PDF]

PLoS ONE, 2012
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury.
Zhenyu Pan, Yueping Guo, Hanping Qi, Kai Fan, Shu Wang, Hua Zhao, Yuhua Fan, Jing Xie, Feng Guo, Yunlong Hou, Ning Wang, Rong Huo, Yong Zhang, Yan Liu, Zhimin Du   +14 more
doaj   +1 more source

Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies. [PDF]

Food Sci Nutr
According to the study, thymol (THY) greatly decreased retches and enhanced latency in a model of chick emesis; the highest effectiveness was shown at 20 mg/kg. According to molecular docking, THY binds strongly to important emetic receptors (5‐HT3A, D2, M3, and H1), indicating a multi‐target mechanism.
Akbor S, Bappi MH, Prottay AAS, Haque F, Mia N, Islam T, Almarhoon ZM, Gürer ES, Setzer WN, Sharifi-Rad J, Al Hasan S, Torequl Islam M.   +11 more
europepmc   +2 more sources

Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium [PDF]

, 1995
In the human isolated myocardium, acetylcholine (10−9 to 10−3 M) elicited a biphasic inotropic effect (a decrease in the lower and an increase in the higher concentration range) in atrial and a positive inotropic effect in ventricular trabeculae. However,
Bos, E. (Egbert), Du, X.Y. (Xiaoyi), Saxena, P.R. (Pramod Ranjan), Schoemaker, R.G. (Regien)   +3 more
core   +7 more sources

Endothelial Cell Organization Drives Distinct Agonist-Specific Ca²⁺ Dynamics in Arteries and Veins. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim The endothelium regulates cardiovascular function by detecting and interpreting multiple extracellular signals from blood and surrounding tissues, even when these inputs are complex and conflicting. The major challenge faced by the endothelium is decoding this dynamic chemical environment to produce coordinated endothelial cellular ...
Lee MD, Clark RA, Buckley C, Zhang X, Uhlen P, Wilson C, McCarron JG.   +6 more
europepmc   +2 more sources

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source