Quaternary Structure Determination of the M3 Muscarinic Acetylcholine Receptors Based on Spectral-FRET [PDF]
Biophysical Journal, 2012 G-protein-coupled receptors (GPCRs) such as human muscarinic acetylcholine receptor 3 (hM3) assume dimeric/oligomeric forms in living cells while maintaining their ability to bind and activate G-proteins. The precise stoichiometry, quaternary organization, and stability of these receptor complexes in living cells remain a subject of significant ...
Suparna Patowary +4 more
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Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]
Cells, 2023 Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng +2 more
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Investigation of muscarinic acetylcholine receptor M3 activation in atomistic detail: a chemist’s viewpoint [PDF]
ChemMedChemMatthäus Drabek +5 more
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Human M3 muscarinic acetylcholine receptor protein-protein interactions: roles in receptor signaling and regualation [PDF]
, 2008 Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate various functions in the central and peripheral nervous systems. These include modulation of exocrine glandular secretion, vasodilatation and smooth muscle contraction, cell proliferation or survival, neural development and synaptic plasticity.
Dasiel O. Borroto‐Escuela
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Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies. [PDF]
Food Sci NutrAccording to the study, thymol (THY) greatly decreased retches and enhanced latency in a model of chick emesis; the highest effectiveness was shown at 20 mg/kg. According to molecular docking, THY binds strongly to important emetic receptors (5‐HT3A, D2, M3, and H1), indicating a multi‐target mechanism.
Akbor S +11 more
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Expression of M3 muscarinic acetylcholine receptors in gastric cancer
Romanian Journal of Morphology and Embryology, 2022 Gastric cancer represents a real public health problem as far as incidence, aggressiveness and unfavorable prognosis are concerned. The autonomous nervous system might be one of the major factors involved in the onset, progression, and metastasis, both sympathetically and parasympathetically.
Mehedinţeanu, Alina Maria +9 more
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Epitomic Profiling and Functional Characteristics of Pemphigus Vulgaris Autoantibody Binding to Keratinocyte M3 Muscarinic Acetylcholine Receptor [PDF]
J Biol ChemJorge Mauricio Reyes‐Ruiz +3 more
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Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis [PDF]
Medical Science Monitor, 2014 Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and ...
Christian Heiss +3 more
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Frontiers in Physiology, 2023 General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos +3 more
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Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency [PDF]
Cell Metabolism, 2006 Most animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating the physiological effects of vagal activation.
Jürgen Wess +7 more
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