Results 41 to 50 of about 13,431 (223)

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +1 more source

Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]

, 2001
DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof, Frohman, Michael A, Zhao, Di   +2 more
core   +3 more sources

The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]

, 2017
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P, Headrick, John P., Neumann, David L., Peart, Jason N., Shum, David H K, Stapelberg, Nicolas J C   +5 more
core   +1 more source

Anti-M3 muscarinic acetylcholine receptor antibodies and Sjögren's syndrome

Japanese Journal of Clinical Immunology, 2013
Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. It is characterized by lymphocytic infiltration into exocrine glands, leading to dry mouth and eyes. A number of auto-antibodies are detected in patients with SS. However, no SS-specific pathologic auto-antibodies have yet been found in
Hiroto, Tsuboi, Mana, Iizuka, Hiromitsu, Asashima, Takayuki, Sumida   +3 more
openaire   +3 more sources

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]

, 2015
The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo, Bassi, Sabrina Cecilia, Seney, Marianne L., Sibille, Etienne   +3 more
core   +1 more source

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. [PDF]

, 2013
Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of ...
Allison D. Fryer, Becky J. Proskocil, Borish L, Crain EF, Crinnion WJ, David B. Jacoby, Donald A. Bruun, Gallo MA, Grodzki AC, Lu C, Nico van Rooijen, Pamela J. Lein, Rozyk KJ   +12 more
core   +1 more source

Muscarinic receptor oligomerization [PDF]

, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins.
Alvarez-Curto, Elisa, Marsango, Sara, Milligan, Graeme, Ward, Richard J.   +3 more
core   +1 more source

Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer

Oncology Letters, 2015
The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. The microarray datasets of GSE3325, including 5 clinically localized primary prostate cancers and 4 benign prostate tissues, were downloaded from the Gene Expression Omnibus database.
Liqiang, Guo, Yuqiang, Liu, Zhibo, Ding, Wendong, Sun, Mingzhen, Yuan   +4 more
openaire   +3 more sources

Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats

Frontiers in Endocrinology, 2021
Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases.
Claudinéia Conationi da Silva Franco, Carina Previate, Amanda Bianchi Trombini, Rosiane Aparecida Miranda, Luiz Felipe Barella, Lucas Paulo Jacinto Saavedra, Júlio Cezar de Oliveira, Kelly Valério Prates, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Audrei Pavanello, Ananda Malta, Isabela Peixoto Martins, Veridiana Motta Moreira, Camila Cristina Ianoni Matiusso, Flávio Andrade Francisco, Vander Silva Alves, Ana Maria Praxedes de Moraes, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Rodrigo Mello Gomes, Elaine Vieira, Paulo Cezar de Freitas Mathias   +22 more
doaj   +1 more source