Results 161 to 170 of about 15,215 (194)

Agonist-induced down-regulation of the m4 muscarinic acetylcholine receptor occurs without changes in receptor mRNA steady-state levels

Naunyn-Schmiedeberg's Archives of Pharmacology, 1994
The regulation of m4 muscarinic acetylcholine receptor mRNA expression by receptor activation was studied in N1E-115 neuroblastoma and AtT-20 pituitary cells that endogeneously express the m4 muscarinic receptor. Receptor concentration was measured by binding of the muscarinic receptor radioligand [3H]quinuclidinyl benzilate, and RNA-RNA solution ...
W, Lenz, C, Petrusch, K H, Jakobs, C J, van Koppen   +3 more
openaire   +2 more sources

Muscarinic Receptor Knockout Mice: Role of Muscarinic Acetylcholine Receptors M2, M3, and M4 in Carbamylcholine-Induced Gallbladder Contractility

The Journal of Pharmacology and Experimental Therapeutics, 2002
Muscarinic receptors play a major role in gallbladder function, although the muscarinic receptor(s) mediating smooth muscle contractility is unclear. This study compared smooth muscle contractile responses to carbamylcholine (10(-7)-10(-3) M) in isolated gallbladder from wild-type and M(2), M(3), and M(4) receptor knockout mice. Carbamylcholine-induced
Peter W, Stengel, Marlene L, Cohen
openaire   +2 more sources

Synthesis and Characterization of Chiral 6-Azaspiro[2.5]Octanes as Potent and Selective Antagonists of the M4 Muscarinic Acetylcholine Receptor.

Bioorganic & Medicinal Chemistry Letters, 2021
Aaron M. Bender, Trever R. Carter, Matthew Spock, Alice L. Rodriguez, J. Dickerson, J. M. Rook, Sichen Chang, Aidong Qi, C. Presley, D. Engers, J. Harp, T. Bridges, C. Niswender, P. Conn, C. Lindsley   +14 more
semanticscholar   +1 more source

Acetylcholine and muscarinic receptor targeting in bipolar disorder: does xanomeline-trospium chloride and other investigational muscarinic agonists hold promise as mechanistically informed treatments for manic episodes, mixed features and cognitive deficits in bipolar disorder?

Expert Opinion on Investigational Drugs
Introduction Xanomeline-trospium chloride (Cobenfy, KarXT) received FDA approval on September 26, 2024, for the treatment of adults with schizophrenia.
R. McIntyre
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Victoria Metaxa   +2 more
exaly  

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

DARIFENACIN REVEALS A FUNCTIONAL ROLE FOR M4 MUSCARINIC ACETYLCHOLINE RECEPTORS IN GUINEA PIG GALLBLADDER

2016
Objective: Previous studies have revealed the presence of M1 to M4 muscarinic receptors in guinea pig gallbladder, with M3 and M4 receptors being claimed to mediate contractions.Methods: In the present study, cumulative concentration-response curves to carbachol were constructed in the absence and presence of darifenacin, which has greater selectivity ...
Akıcı, Ahmet, Nacak, Muradiye, Christopoulos, Arthur, Oktay, Şule   +3 more
openaire   +1 more source

Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium

, 2016
D. Thal, B. Kobilka, P. Sexton, A. Christopoulos   +3 more
semanticscholar   +1 more source