Results 21 to 30 of about 2,691 (151)

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

Acetylcholine and spinal locomotor networks: The insider

Physiological Reports, 2021
This article aims to review studies that have investigated the role of neurons that use the transmitter acetylcholine (ACh) in controlling the operation of locomotor neural networks within the spinal cord. This cholinergic system has the particularity of
Théo Mille, Camille Quilgars, Jean‐René Cazalets, Sandrine S. Bertrand   +3 more
doaj   +1 more source

Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects

Plants, 2023
Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated a diverse range of biological activities. The primary objective of the current study is to assess the potential antiemetic properties of QUA using an in vivo and ...
Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib, Rubel Hasan, Henrique Douglas Melo Coutinho, Isaac Moura Araújo, Irwin Rose Alencar de Menezes, Muhammad Torequl Islam   +7 more
doaj   +1 more source

Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts

Journal of Pharmacological Sciences, 2009
.: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga, Takahisa Murata, Muneyoshi Okada, Masatoshi Hori, Hiroshi Ozaki   +4 more
doaj   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]

Geriatr Gerontol Int
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Mogi M, Liu S, Suzuki Y, Shibata Y, Yamada S.   +4 more
europepmc   +2 more sources

Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma

Journal of Pharmacological Sciences, 2007
Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim, Sang Hoon Rah, Joon Hyung Sohn, Byung-Il Yeh, Chang Mann Ko, Jeong Sook Park, Min-Jeong Kim, Joong Woo Lee, In Deok Kong   +8 more
doaj   +1 more source

The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice

Scientific Reports, 2019
Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for glaucoma. We tested the hypothesis that the lack of a single muscarinic receptor subtype leads to age-dependent neuron reduction in the retinal ganglion cell
Panagiotis Laspas, Mayagozel B. Zhutdieva, Christoph Brochhausen, Aytan Musayeva, Jenia Kouchek Zadeh, Norbert Pfeiffer, Ning Xia, Huige Li, Juergen Wess, Adrian Gericke   +9 more
doaj   +1 more source

M1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior

Pharmacology Research & Perspectives, 2022
Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate alcohol consumption and seeking. Both M4 and M5 mAChRs have been highlighted as potential novel treatment targets for alcohol use disorders (AUD).
Leigh C. Walker, Erin J. Campbell, Kate L. Huckstep, Nicola A. Chen, Christopher J. Langmead, Andrew J. Lawrence   +5 more
doaj   +1 more source

Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Azadi MH, Pazooki P, Ajdary S, Shafaroodi H.   +3 more
europepmc   +2 more sources

Muscarinic Acetylcholine Receptor M5 Involved in Spermatogenesis through the Modification of Cell-Cell Junctions [PDF]

, 2020
Abstract The authors have withdrawn this preprint due to author disagreement.
Yong Zhao, Xiao Han, Pengfei Zhang, Wei Shen, Hongfu Zhang, Cong Zhang, Bohui Xiong, Shen Yin, Zhaojia Ge   +8 more
openaire   +2 more sources