Results 41 to 50 of about 1,293,750 (146)

Expression and Function of the Cholinergic System in Immune Cells

Frontiers in Immunology, 2017
T and B cells express most cholinergic system components—e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively).
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

The Interactions Between Acetylcholine and T‐Cells and Their Role in the Immune System: A Scoping Review

Immunology, EarlyView.
Activated T‐cells instigate signalling events leading to the activation of transcription factors, which in turn, act on the nucleus to produce cytokines. We postulate that c‐fos is one of these transcription factors which upregulates the choline acetyltransferase gene responsible for synthesising acetylcholine (ACh).
Jarita Lay, Nicholas Manolios
wiley   +1 more source

The molecular basis of V2 vasopressin receptor-G Protein coupling selectivity [PDF]

, 2003
G­Protein­gekoppelte Rezeptoren (GPCRs) stellen eine der größten in der Natur vorkommenden Proteinfamilien dar (Watson and Arkinstall, 1994). GPCRs sind plasmamembranständige Proteine, die mit heterotrimären G­Proteinen interagieren und eine Vielzahl an ...
Erlenbach, Isolde
core  

Extrasynaptic acetylcholine signaling through a muscarinic receptor regulates cell migration [PDF]

, 2021
Acetylcholine (ACh) promotes various cell migrations in vitro, but there are few investigations into this nonsynaptic role of ACh signaling in vivo.
Gharib, S., Kato, M., Kato, Mihoko, Kolotuev, Irina, Cunha, A., Sternberg, P.W., Kolotuev, I., Sternberg, Paul W., Gharib, Shahla, Cunha, Alexandre   +9 more
core   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor [PDF]

, 2010
Muscarinic acetylcholine receptors (MRs), a family of five G protein-coupled receptors (GPCRs), play an essential role in the regulation of mammalian physiology.
Bendor, Jacob T
core   +1 more source

Identification of a novel allosteric site at the M5 muscarinic acetylcholine receptor

, 2021
The M5 muscarinic acetylcholine receptor (mAChR) has emerged as an exciting therapeutic target for the treatment of addiction and behavioral disorders.
Vuckovic, Ziva, Langmead, Christopher J., Christopoulos, Arthur, Thompson, Geoff, Burger, Wessel A. C., Tobin, Andrew B., Lindsley, Craig W., Valant, Celine, Sexton, Patrick M., Yeasmin, Mahmuda, Thal, David M., Berizzi, Alice E., van der Westhuizen, Emma T., Gentry, Patrick R.   +13 more
core   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR

Nature Communications
The M5 muscarinic acetylcholine receptor (M5 mAChR) represents a promising therapeutic target for neurological disorders. However, the high conservation of its orthosteric binding site poses significant challenges for drug development.
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal   +13 more
doaj   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source