Results 91 to 100 of about 26,727 (247)
PLoS Pathogens, 2015 Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus ...
Matthew Darby +11 more
doaj +1 more source
Medical treatment of female overactive bladder syndrome and treatment-related effects
Journal of the Formosan Medical Association, 2018 The age-adjusted prevalence of overactive bladder syndrome (OAB) in Taiwan is approximately 16.9%. Currently, a variety of treatments are available for female OAB.
Sheng-Mou Hsiao, Ho-Hsiung Lin
doaj +1 more source
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Muscarinic receptors and drugs in cardiovascular medicine
, 1995 The parasympathetic system and its associated muscarinic receptors have been the subject of a renaissance of interest for the following two main reasons: (1) the association of endothelial muscarinic receptors and the nitric oxide (NO) pathway; (2) the ...
van Zwieten, P. A., Doods, H. N.
core +1 more source
A Difference in Receptor Mechanisms for Muscarinic Full and Partial Agonists
Japanese Journal of Pharmacology, 1991 Concentration-response curves of 4 muscarinic full agonists were progressively inhibited by 10 to 50-min treatments of the longitudinal muscle of guinea pig ileum with propylbenzilylcholine mustard (PrBCM, 3 x 10(-6) M). A 90-min treatment with PrBCM had no further significant inhibitory effect on their curves.
Takayanagi, Issei +2 more
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Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.ABSTRACT Background In‐hospital use of non‐invasive ventilation improves outcomes in patients with acute respiratory failure caused by acute exacerbation of chronic obstructive pulmonary disease. Prehospital use of non‐invasive ventilation is uncommon due to diagnostic uncertainty and logistical constraints.
Jesper H. Brendel +10 more
wiley +1 more source
Effects of muscarinic toxins MT1 and MT2 from green mamba on different muscarinic cholinoceptors
, 2002 MT1 and MT2, polypeptides from green mamba venom, known to bind to muscarinic cholinoceptors, behave like muscarinic agonists in an inhibitory avoidance task in rats.
Adrover, Martin +7 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau +9 more
wiley +1 more source
Muscarinic Receptor Agonists and Antagonists: Effects on Cancer [PDF]
, 2011 Many epithelial and endothelial cells express a cholinergic autocrine loop in which acetylcholine acts as a growth factor to stimulate cell growth. Cancers derived from these tissues similarly express a cholinergic autocrine loop and ACh secreted by the cancer or neighboring cells interacts with M3 muscarinic receptors expressed on the cancer cells to ...
openaire +2 more sources