Results 111 to 120 of about 26,727 (247)

Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy

, 2018
Objectives Alzheimer's disease (AD) has become the primary cause of dementia. It shows a progressive cognitive dysfunction with degenerating neurons. Acetylcholine receptors (AChRs) propagate the cognitive ability and it consists of two
Stuti Verma, Ashwini Kumar, Timir Tripathi, Awanish Kumar   +3 more
core   +1 more source

Positioning new pharmacotherapies for COPD

International Journal of COPD, 2015
Igor Z Barjaktarevic,1 Anthony F Arredondo,1 Christopher B Cooper1,2 1Department of Medicine, 2Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Abstract: COPD imposes ...
Barjaktarevic IZ, Arredondo AF, Cooper CB   +2 more
doaj  

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL‐G‐F KI mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Takuya Ooba, Toyohiro Sato, Yuto Uchida, Itsumi Nagai‐Arakawa, Takashi Saito, Hideaki Hara, Hideki Hida, Noriyuki Matsukawa   +10 more
wiley   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Kv7 and K2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi, Guiscard Seebohm, Thomas Budde, Annika Lüttjohann   +3 more
wiley   +1 more source

Muscarinic receptor subtypes - search for selective agonists and antagonists

, 1996
Since the late eighties five muscarinic receptor subtypes (m1 - m5) have been cloned and four of them (M1 - M4) have also been pharmacologically characterized. However, there is still a lack of potent muscarinic agonists and antagonists, which are highly
Gross, Jan, Mendla, Klaus, Tacke, Reinhold, J. Gross, E. Mutschler, D. Reichel, K. Mendla, Rühlmann, K., J. Wehrle, U. Moser, Lambrecht, Günter, K. Rühlmann, M. Waelbroeck, Waelbroeck, Magali, Ensinger, Helmut H.A., O. Pfaff, Moser, Ulrich, Reichel, Dirk, R. Tacke, A. Leis, Mutschler, Ernst, Leis, Albrecht, Pfaff, Otmar, Wehrle, Jahn, H.A. Ensinger, G. Lambrecht   +25 more
core   +1 more source

MiR‐21‐5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
miR‐21‐5p protects embryonic growth and heart function during developmental hypoxia by dampening HIF responses and shifting gene networks toward improved cardiomyocyte survival and calcium handling. This work identifies miR‐21‐5p as a promising therapeutic target for preventing fetal growth restriction and cardiovascular impairment in high‐risk ...
Bernardo J. Krause, Ximena Calle, Ranya V. Kumar, Youguo Niu, Oriana Ramirez‐Herrera, Damariz Gonzalez, Barbara Bernal, Sage G. Ford, Rachael C. Crew, Anna L. K. Cochrane, German A. Arenas, Alex Di Genova, Dino A. Giussani   +12 more
wiley   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives

Frontiers in Molecular Biosciences
Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim, Mohamed M. Ibrahim, Mohamed M. Ibrahim, Monica M. Jablonski, Monica M. Jablonski   +4 more
doaj   +1 more source