Results 121 to 130 of about 26,727 (247)

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Junya Maruoka, Ryo Egami, Yuto Akita, Kohei Kozuka, Yusuke Kakumoto, Tetsuro Kikuchi, Kazuhiko Kume   +6 more
wiley   +1 more source

Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor

, 2013
Background and Purpose Artificial agonists may have higher efficacy for receptor activation than the physiological agonist. Until now, such 'superagonism' has rarely been reported for GPCRs. Iperoxo is an extremely potent muscarinic receptor agonist.
E. Kostenis, K. Mohr, M. De Amici, J. Klöckner, C. Dallanoce, U. Holzgrabe, R. Schrage, W. K. Seemann, K. Racké   +8 more
core   +1 more source

The reasons for triple therapy in stable COPD patients in Japanese clinical practice

International Journal of COPD, 2015
Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio ...
Miyazaki M, Nakamura H, Takahashi S, Chubachi S, Sasaki M, Haraguchi M, Terai H, Ishii M, Fukunaga K, Tasaka S, Soejima K, Asano K, Betsuyaku T   +12 more
doaj  

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

Propylbenzilylcholine mustard is selective for rat heart muscarinic receptors having a low affinity for agonists.

, 1986
Propylbenzilylcholine mustard (PrBCM), an irreversible muscarinic antagonist, inactivated receptors with a low affinity for agonists faster than those with a high affinity in rat heart membranes.
Christophe, Jean, De Neef, Philippe, Waelbroeck, Magali, Robberecht, Patrick   +3 more
core   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Signalling and receptor crosstalk mediated by full and partial agonists of the muscarinic M3 receptor

, 2006
This study shows that stimulation of endogenously expressed Galpha q/11-coupled muscarinic M3 receptors in HEK 293 cells allows a subsequent robust Ca2+ response to stimulation of beta 2-adrenoceptors.
Nisha Kurian (94350)
core  

A QSAR Approach to the Study of Structural Requirements of Muscarinic Receptor Ligands Part I: Agonists

, 1992
This report examines the development of quantitative structure‐activity relationships (QSAR) in the analysis of ligand muscarinic receptor interactions. Several sets of agonists acting on different tissues (distinct receptor subtypes) are considered.
G. Caliendo, C. Silipo, Pratesi, P., CALIENDO, GIUSEPPE, P. Pratesi, Vittoria, A., Silipo, C., A. Vittoria   +7 more
core   +1 more source

Fentanyl Compromises Lower‐Airway Mechanics and Naloxone Triggers a Transient Mechanical Overshoot

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the leading cause of death following opioid overdose, due to its effects on central rhythm generation, and airway and thoracic constriction. While the effects on rhythm generation have been well documented, the effects of fentanyl on airway constriction are less well understood. We tested the
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Madeline M. Johnson, Nicholas J. Burgraff   +4 more
wiley   +1 more source

Comparison of the effects of selective and nonselective muscarinic agonists on cognition and thermoregulation in primates.

, 1992
Peripheral toxicity may explain the disappointing therapeutic effects of nonselective muscarinic agonists in Alzheimer's disease. Partial agonists might exhibit an improved therapeutic index.
Tye, SJ, Rupniak, NM, Iversen, SD, Iversen, Susan   +3 more
core   +1 more source