Results 141 to 150 of about 26,727 (247)

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda, Renu Khasa, Srinivasan Chinnapaiyan, Saurabh Aggarwal, Irfan Rahman, Hoshang Unwalla   +5 more
wiley   +1 more source

Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists

, 2011
The five muscarinic acethylcoline receptors (M1-M5) mediate many physiological functions and, therefore, represent important therapeutic targets. The M1 muscarinic subtype, widely expressed post-synaptically in cortex and hippocampus, is involved in CNS ...
PIERGENTILI, Alessandro, M. Cancellieri, M. Pollastrini, C. Castaldo, A. Bonifazi, M. Nesi, GIANNELLA, Mario, PIGINI, Maria, QUAGLIA, Wilma, Rosanna Matucci, DEL BELLO, FABIO   +10 more
core  

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells. [PDF]

J Neurochem
Guerriero C, De Nuccio C, Petrone M, Rinaldi T, Cirigliano A, Visentin S, Bernardo A, Conti L, Matera C, De Amici M, Dallanoce C, Tata AM.   +11 more
europepmc   +1 more source

Agonist--Antagonist--Muscarinic Receptor Ternary Complex. [PDF]

Acta Chemica Scandinavica, 1980
Britta Hedlund, Anders Undén, Marlena Grynfarb, Tamas Bartfai, Curt R. Enzell   +4 more
openaire   +2 more sources

Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function. [PDF]

Diabetes
Levi NJ, Tamayo Garcia A, Sokolov M, Barro-Soria R, Caicedo A.   +4 more
europepmc   +1 more source

Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss. [PDF]

Int J Mol Sci
Oman J, Sapkota P, Mateen S, Schulte M, Pashikanti S.   +4 more
europepmc   +1 more source

Selective agonists for M2 muscarinic receptors inhibit cell proliferation and survival in human glioblastoma cells: Possible implications in drug resistance

, 2015
Introduction. The involvement of muscarinic receptors in cancer has been largely documented. Recently, we have demonstrated that the activation of M2 muscarinic receptors, by the agonist Arecaidine Propargyl Ester (APE), arrests cell proliferation and ...
I. Cristofaro, C. Matera, M. De Amici, Z. Spinello, A. M. Tata, C. Dallanoce, R. Fanfarillo, M. Di Bari, L. Conti   +8 more
core  

Integrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review. [PDF]

Cells
Roy S, Gangipangi VK, Sharma P, Hancock RE, Sharma P.   +4 more
europepmc   +1 more source

An Explorative Approach to Examining the Role of Ischemia and Inflammation on the Function of Autoantibodies Against G Protein-Coupled Receptors and Their Corresponding Agonists. [PDF]

Int J Mol Sci
Wallukat G, Lakatos P, Steinhorst K, Flecks M, Hohberger B.   +4 more
europepmc   +1 more source

Long-acting β₂ agonist (LABA) with a long-acting muscarinic receptor antagonist (LAMA) promotes human airway smooth muscle (HASM) relaxation and circumvents β₂ adrenergic receptor tachyphylaxis. [PDF]

Respir Res
Jude J, Karmacharya N, Sherpa RT, O'Riordan TG, Koziol-White CJ, Panettieri RAJ.   +5 more
europepmc   +1 more source