Results 131 to 140 of about 26,727 (247)
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
Muscarinic acetylcholine receptors : investigation of interactions with agonists and antagonists
, 1981 In the present investigation interactions of agonists and antagonists with the muscarinic acetylcholine receptor from rat cerebral cortex and rat ileum smooth muscle have been characterized.It is suggested that the binding of antagonist involves two ...
Hedlund, Britta,
core
Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.ABSTRACT Diabetic peripheral neuropathy (DPN) is a prevalent and disabling complication of diabetes, yet whether established clinical DPN is reversible remains debated. At the 35th Annual Meeting of NEUROdiab, a formal debate examined arguments ‘for’ and ‘against’ the proposition that clinical DPN can be reversed.
Gordon Sloan +9 more
wiley +1 more source
Differences in Ca2+ mobilization by muscarinic agonists in tracheal smooth muscle
, 1993 The muscarinic agonists acetylcholine (ACh) and McN-A-343 activate a homogeneous population of M3 receptors in canine tracheal smooth muscle. However, ACh is much more efficacious than McN-A-343 both at stimulating force development and active ...
M. H. al-Hassani +2 more
core +1 more source
Computational Quantification of Peristalsis in Preclinical Mouse Models Using Smartphone Videography
Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.A new computational method and analytical pipeline for quantifying gut peristalsis in live mouse models that involves taking a video using a smartphone camera and then processing the videographic data using our custom analytical pipeline to quantify gastrointestinal motility.
Joseph C. Schindler +4 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 6, Page 2987-2999, 1 June 2026.Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad +5 more
wiley +1 more source
Muscarinic Agonists and Antagonists: Effects on Gastrointestinal Function
, 2012 Muscarinic agonists and antagonists are used to treat a handful of gastrointestinal (GI) conditions associated with impaired salivary secretion or altered motility of GI smooth muscle.
Pak, K. J. +2 more
core
The endogenous cannabinoid system gates plasticity of tonic GABA inhibition
The Journal of Physiology, Volume 604, Issue 12, Page 4984-5010, 15 June 2026.Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Roberto Colangeli, Fiorenzo Conti
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The Journal of Physiology, Volume 604, Issue 12, Page 4945-4967, 15 June 2026.Abstract figure legend Obesity and metabolic syndrome (MetS) are well‐known major risk factors for overactive bladder (OAB). Mechanisms underlying obesity‐/MetS‐associated OAB were explored using a high‐fat‐diet (HFD)‐induced obesity mouse model. HFD‐induced obesity/MetS mice developed an OAB phenotype characterized by enlarged non‐voiding contractions
Ayu Sugiura +3 more
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