Results 1 to 10 of about 2,979 (198)
Multitargeting nature of muscarinic orthosteric agonists and antagonists
Frontiers in Physiology, 2022 Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists ...
Jaromir Myslivecek
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Cells, 2022 Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta +2 more
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Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park +3 more
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Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
Scientific Reports, 2021 Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons
Jose L. Herrero, Alexander Thiele
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Functional effects of KCNQ K+ channels in airway smooth muscle
Frontiers in Physiology, 2013 KCNQ (Kv7) channels underlie a voltage-gated K+ current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue
Alexey I Evseev +7 more
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Journal of Pharmacological Sciences, 2016 The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit +6 more
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The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. [PDF]
PLoS ONE, 2011 Adenosine, a catabolite of ATP, displays a wide variety of effects in the heart including regulation of cardiac response to myocardial ischemia and reperfusion injury.
Lei Sun +8 more
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ACSEE: Antagonistic Crowd Simulation Model with Emotional Contagion and Evolutionary Game Theory [PDF]
IEEE Transactions on Affective Computing (2019), 2019 Antagonistic crowd behaviors are often observed in cases of serious conflict. Antagonistic emotions, which is the typical psychological state of agents in different roles (i.e. cops, activists, and civilians) in crowd violent scenes, and the way they spread through contagion in a crowd are important causes of crowd antagonistic behaviors.
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Journal of Clinical and Biomedical Sciences, 2018 Revefenacin, a long-acting muscarinic receptor antagonist was approved by US Food and Drug Administration in November 2018 for the maintenance treatment of patients with Chronic Obstructive Pulmonary Disease (COPD).
Bhuvana K
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Cells, 2023 Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude +4 more
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