Results 1 to 10 of about 527,442 (166)

Once-daily glycopyrronium bromide, a long-acting muscarinic antagonist, for chronic obstructive pulmonary disease: a systematic review of clinical benefit

International Journal of COPD, 2012
Background: Long-acting bronchodilators are central in the pharmacological management of patients with chronic obstructive pulmonary disease (COPD). The aim of this systematic review is to provide an overview of the studies evaluating the safety and ...
Ulrik CS
openalex   +3 more sources

The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task [PDF]

Experimental Brain Research, 1995
Paul M. Grasby, Chris Frith, Eraldo Paulesu, Karl Friston, R. S. J. Frackowiak, Raymond J. Dolan   +5 more
openalex   +2 more sources

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist [PDF]

Nature, 2012
Kazuko Haga, Andrew C. Kruse, Hidetsugu Asada, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Cheng Zhang, William I. Weis, Tetsuji Okada, Brian K. Kobilka, Tatsuya Haga, Takuya Kobayashi   +10 more
openalex   +2 more sources

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia.

New England Journal of Medicine, 2021
BACKGROUND The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events.
S. Brannan, S. Sawchak, Andrew C. Miller, J. Lieberman, S. Paul, A. Breier   +5 more
semanticscholar   +1 more source

Multitargeting nature of muscarinic orthosteric agonists and antagonists

Frontiers in Physiology, 2022
Muscarinic receptors (mAChRs) are typical members of the G protein-coupled receptor (GPCR) family and exist in five subtypes from M1 to M5. Muscarinic receptor subtypes do not sufficiently differ in affinity to orthosteric antagonists or agonists ...
Jaromir Myslivecek
doaj   +1 more source

Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park, Park-Ne Kim, Seong-Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

TLR2 and TLR4 Modulate Mouse Ileal Motility by the Interaction with Muscarinic and Nicotinic Receptors

Cells, 2022
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta, Raquel Forcén, Laura Grasa   +2 more
doaj   +1 more source

Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1

Scientific Reports, 2021
Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons
Jose L. Herrero, Alexander Thiele
doaj   +1 more source

Nebulized Versus Dry Powder Long-Acting Muscarinic Antagonist Bronchodilators in Patients With COPD and Suboptimal Peak Inspiratory Flow Rate.

Chronic obstructive pulmonary diseases, 2019
Background Patients with chronic obstructive pulmonary disease (COPD) and suboptimal peak inspiratory flow rate (sPIFR) may not benefit optimally from dry powder inhalers (DPI) because of inadequate inspiratory flow. Nebulized bronchodilators may provide
D. Mahler, J. Ohar, C. Barnes, E. Moran, S. Pendyala, G. Crater   +5 more
semanticscholar   +1 more source

Functional effects of KCNQ K+ channels in airway smooth muscle

Frontiers in Physiology, 2013
KCNQ (Kv7) channels underlie a voltage-gated K+ current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue
Alexey I Evseev, Iurii eSemenov, Iurii eSemenov, Crystal eArcher, Jorge eMedina, Peter H Dube, Mark S Shapiro, Robert eBrenner   +7 more
doaj   +1 more source