Dupilumab Efficacy and Safety in Patients With Persistent Asthma: Asia–Pacific Region
Clinical &Experimental Allergy, EarlyView.Asthma prevalence is increasing in the Asia–Pacific region, and this population is frequently underrepresented in phase 3 clinical studies. We demonstrate Dupilumab's efficacy and safety among patients with uncontrolled moderate‐to‐severe type 2 asthma.
Qingling Zhang +13 more
wiley +1 more source
Convulsant bicuculline modifies CNS muscarinic receptor affinity
BMC Neuroscience, 2006 Background Previous work from this laboratory has shown that the administration of the convulsant drug 3-mercaptopropionic acid (MP), a GAD inhibitor, modifies not only GABA synthesis but also binding of the antagonist [3H]-quinuclidinyl benzilate ([3H ...
Rodríguez de Lores Arnaiz Georgina +1 more
doaj +1 more source
Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease. [PDF]
Cochrane Database Syst Rev, 2023 Fukuda N +6 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Inconsistent associations have been reported between steatotic liver disease (SLD) and depression. We aimed to investigate the cross‐sectional and prospective associations between MRI‐derived liver fat, SLD and depression. Materials and Methods We used UK Biobank data. Liver fat was measured with liver MRI proton density fat fraction. SLD
Qi Feng +3 more
wiley +1 more source
The efficacy and safety of additional treatment with short-acting muscarinic antagonist combined with long-acting beta-2 agonist in stable patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. [PDF]
Chron Respir Dis, 2023 Tanimura K +7 more
europepmc +1 more source
The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents [PDF]
, 1977 Daniel Cavey +2 more
openalex +1 more source
Internal Medicine Journal, EarlyView.Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley +1 more source
Possible involvement of acetylcholine-mediated inflammation in airway diseases
Allergology International, 2018 Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs ...
Akira Koarai, Masakazu Ichinose
doaj
ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]
, 1980 David A. Brown, A. FORWARD, S. Marsh
openalex +1 more source
Turning the tide on bronchiectasis in adult Aboriginal Australians: from neglect to action
Internal Medicine Journal, EarlyView.Abstract Chronic respiratory disorders are highly prevalent among adult Aboriginal and Torres Strait Islander peoples, with emerging evidence suggesting that there is a significant burden of bronchiectasis contributing to overall higher morbidity and mortality.
Subash S. Heraganahally +8 more
wiley +1 more source