Results 91 to 100 of about 27,985 (262)

Efficacy of Open‐Ended Urinary Catheters in Preventing Catheter‐Related Bladder Discomfort: A Randomized Controlled Trial

International Journal of Urology, EarlyView.
ABSTRACT Objective Catheter‐related bladder discomfort (CRBD) is a common postoperative complication following urological procedures, causing significant distress and reducing patient satisfaction. Although pharmacological interventions have been investigated, a more definitive approach is warranted.
Kohei Kobatake, Keisuke Goto, Tomoya Hatayama, Miki Naito, Kenshiro Takemoto, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata   +10 more
wiley   +1 more source

Role of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats [PDF]

Veterinary Research Forum, 2011
The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic
Esmaeal Tamaddonfard, Amir-Abbas Farshid, Sona Seiednejhad, Asghar Morvaridi   +3 more
doaj  

Treatment Patterns, Healthcare Utilization and Clinical Outcomes of Patients with Chronic Obstructive Pulmonary Disease Initiating Single-Inhaler Long-Acting β₂-Agonist/Long-Acting Muscarinic Antagonist Dual Therapy in Primary Care in England. [PDF]

Int J Chron Obstruct Pulmon Dis, 2023
Requena G, Banks V, Czira A, Wood R, Tritton T, Wild R, Compton C, Ismaila AS.   +7 more
europepmc   +1 more source

An Algorithm for the Diagnosis and Management of Severe Asthma in Children and Adolescents

Allergy, EarlyView.
Eckard Hamelmann, Bianca Schaub, Susanne Lau, Leonard B. Bacharier   +3 more
wiley   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, EarlyView.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

Molecular mechanism of human α1A-adrenoceptor inhibition by Mamba snake toxin AdTx1

Communications Biology
There is growing interest in peptide or small protein based drugs targeting G protein-coupled receptors (GPCRs) for improved subtype selectivity over small molecules. Naturally occurring toxins represent rich sources of such ligands.
Mingyu Shi, Shuhao Zhang, Angqi Zhu, Yosuke Toyoda, Fang Kong, Xiaoou Sun, Xinyu Xu, Chuangye Yan, Xiangyu Liu   +8 more
doaj   +1 more source

Real-world effects of once-daily inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) and long-acting muscarinic antagonist (umeclidinium) on lung function tests of asthma patients in Japan. [PDF]

Front Physiol, 2023
Umeda A, Shimada H, Yamane T, Mochizuki T, Inoue Y, Tsushima K, Miyagawa K, Mochida A, Takeda H, Okada Y, Masaki K, Matsusaka M, Fukunaga K.   +12 more
europepmc   +1 more source

Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat [PDF]

, 1990
Carlo Polidori, Maurizio Massi, Günter Lambrecht, E. Mutschler, Reinhold Tacke, Carlo Melchiorre   +5 more
openalex   +1 more source

Muscarinic Receptor Agonists and Antagonists: Effects on Cancer [PDF]

, 2011
Many epithelial and endothelial cells express a cholinergic autocrine loop in which acetylcholine acts as a growth factor to stimulate cell growth. Cancers derived from these tissues similarly express a cholinergic autocrine loop and ACh secreted by the cancer or neighboring cells interacts with M3 muscarinic receptors expressed on the cancer cells to ...
openaire   +3 more sources

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source