Results 91 to 100 of about 566,083 (307)

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]

, 1980
David A. Brown, A. FORWARD, S. Marsh
openalex   +1 more source

Biomarkers to Predict Response to Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists in Adolescents and Adults with Mild Persistent Asthma

, 2021
Jerry A. Krishnan, Stephen C. Lazarus, Kathryn Blake, Christine A. Sorkness, Ronina Covar, Anne‐Marie Dyer, Jason E. Lang, Njira Lugogo, David T. Mauger, Michael E. Wechsler, Sally E. Wenzel, Juan Carlos Cardet, Mario Castro, Elliot Israel, Wanda Phipatanakul, Tonya S. King   +15 more
openalex   +2 more sources

Test–retest reliability of Doppler ultrasound‐based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

Experimental Physiology, EarlyView.
Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad, Jacob P. Hartmann, Amalie B. Andersen, Helene L. Hartmeyer, Ulrik W. Iepsen, Ronan M. G. Berg   +5 more
wiley   +1 more source

Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults with asthma [PDF]

, 2015
David Evans, Kayleigh M Kew, Debbie E Anderson, Anne Boyter   +3 more
openalex   +1 more source

Effects of Long-acting Muscarinic Antagonists on Promoting Ciliary Function in Airway Epithelium

, 2021
Mineo Katsumata, Tomoyuki Fujisawa, Yosuke Kamiya, Yūko Tanaka, Chiaki Kamiya, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Masato Maekawa, Mitsutoshi Setou, Hiroshi Watanabe, Koji Ikegami, Takafumi Suda   +17 more
openalex   +1 more source

Convulsant bicuculline modifies CNS muscarinic receptor affinity

BMC Neuroscience, 2006
Background Previous work from this laboratory has shown that the administration of the convulsant drug 3-mercaptopropionic acid (MP), a GAD inhibitor, modifies not only GABA synthesis but also binding of the antagonist [3H]-quinuclidinyl benzilate ([3H ...
Rodríguez de Lores Arnaiz Georgina, Schneider Patricia G   +1 more
doaj   +1 more source

Comparison of pneumonia incidence between long-acting muscarinic antagonist and inhaled corticosteroid plus long-acting beta agonist in patients with COPD. [PDF]

Sci Rep, 2023
Lee EG, Kim Y, Hwang YI, Yoo KH, Lee SE, Jung KY, Lee D, Park YB, Rhee CK.   +8 more
europepmc   +1 more source

Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists.

Chemical and Pharmaceutical Bulletin, 2000
A series of 5H-dibenz[b,f]azepine derivatives was prepared and evaluated for binding affinities to muscarinic receptors in vitro. Among them, compound 8 showed a high affinity for human recombinant M2 receptors (Ki=2.6 nm), a low affinity for M4 receptors (39-fold less than for M2 receptors) and a very low affinity for M1 and M3 receptors (119- and 112-
G R, Mandelli, S, Maiorana, P, Terni, G, Lamperti, M L, Colibretti, B P, Imbimbo   +5 more
openaire   +3 more sources

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, EarlyView.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source