Results 101 to 110 of about 2,979 (198)
Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat [PDF]
, 1990 Carlo Polidori +5 more
openalex +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
The effect of allosteric antagonists in modulating muscarinic M2‐receptor function in guinea‐pig isolated trachea [PDF]
, 1994 Domenico Spina +3 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2012 Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ...
B. Cam-Etoz +2 more
doaj +2 more sources
Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease
Therapeutics and Clinical Risk Management, 2014 Jun Zhong, Michael Roth Pneumology and Pulmonary Cell Research, Department of Biomedicine and Internal Medicine, University Hospital Basel, Basel, Switzerland Abstract: Chronic obstructive pulmonary disease (COPD) is increasing worldwide and is ...
Zhong J, Roth M
doaj
Differential regulation of human cardiac beta‐adrenergic and muscarinic receptors by chronic beta‐adrenoceptor antagonist treatment. [PDF]
, 1990 Shigeru Motomura +4 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra +4 more
wiley +1 more source
The possible mechanisms of protocatechuic acid-induced central analgesia
Saudi Pharmaceutical Journal, 2018 It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C, α2-adrenergic and muscarinic receptors in protocatechuic acid-induced central analgesia in mice ...
Rana Arslan +3 more
doaj
Best practices for blood collection and anaesthesia in mice: Selection, application and reporting
British Journal of Pharmacology, EarlyView.Abstract Blood collection in mice is a common procedure in biomedical research. The choice of blood collection method and the need for analgesia and/or anaesthesia depend on multiple factors, including the experimental setup, animal welfare considerations and the intended downstream analyses.
Zhixin Li +10 more
wiley +1 more source