Results 111 to 120 of about 51,268 (235)
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel +5 more
wiley +1 more source
Annals of the New York Academy of Sciences, EarlyView.Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg +4 more
wiley +1 more source
Convulsant bicuculline modifies CNS muscarinic receptor affinity
BMC Neuroscience, 2006 Background Previous work from this laboratory has shown that the administration of the convulsant drug 3-mercaptopropionic acid (MP), a GAD inhibitor, modifies not only GABA synthesis but also binding of the antagonist [3H]-quinuclidinyl benzilate ([3H ...
Rodríguez de Lores Arnaiz Georgina +1 more
doaj +1 more source
Comparison of pneumonia incidence between long-acting muscarinic antagonist and inhaled corticosteroid plus long-acting beta agonist in patients with COPD. [PDF]
Sci Rep, 2023 Lee EG +8 more
europepmc +1 more source
Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists.
Chemical and Pharmaceutical Bulletin, 2000 A series of 5H-dibenz[b,f]azepine derivatives was prepared and evaluated for binding affinities to muscarinic receptors in vitro. Among them, compound 8 showed a high affinity for human recombinant M2 receptors (Ki=2.6 nm), a low affinity for M4 receptors (39-fold less than for M2 receptors) and a very low affinity for M1 and M3 receptors (119- and 112-
G R, Mandelli +5 more
openaire +3 more sources
Exercise‐induced dynamic hyperinflation in chronic obstructive pulmonary disease
Experimental Physiology, EarlyView.Abstract Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease caused by inhalation of noxious particles, most commonly cigarette smoking. The consequent changes in airways, lung parenchyma and pulmonary vasculature lead to increased resistive, elastic and threshold loads and impaired capacity of the respiratory muscle pump. COPD
Rebecca F. D'Cruz +2 more
wiley +1 more source
Cholinergic neurons in the dorsomedial hypothalamus regulate food intake
Molecular Metabolism, 2017 Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong +2 more
doaj +1 more source
Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease. [PDF]
Cochrane Database Syst Rev, 2023 Fukuda N +6 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad +5 more
wiley +1 more source
Hypertensive Urgency after Administration of a Single Low Dose of Mirtazapine- A Case Report
Iranian Journal of Public Health, 2015 Mirtazapine is a new antidepressant that can increase noradrenergic and serotonergic neurotransmission. It is also a postsynaptic antagonist of 5-HT2 and 5-HT3.
Jiana Shi +4 more
doaj