The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Role of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats [PDF]
Veterinary Research Forum, 2011 The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic
Esmaeal Tamaddonfard +3 more
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Effect of Adding Inhaled Corticosteroid to Long-Acting Muscarinic Antagonist/Long-Acting Beta-Agonist Therapy Among Patients With Chronic Obstructive Pulmonary Disease. [PDF]
Cureus, 2021 Yuasa M +8 more
europepmc +1 more source
Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction
Neurogastroenterology &Motility, EarlyView.Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley +1 more source
Revefenacin, a once-daily, long-acting muscarinic antagonist, for nebulized maintenance therapy in patients with chronic obstructive pulmonary disease. [PDF]
Am J Health Syst Pharm, 2021 Hvisdas C.
europepmc +1 more source
Neurogastroenterology &Motility, EarlyView.Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz +4 more
wiley +1 more source
The role of long-acting muscarinic antagonist/long-acting β agonist fixed-dose combination treatment for chronic obstructive pulmonary disease in China: a narrative review. [PDF]
J Thorac Dis, 2021 Zhou J +6 more
europepmc +1 more source
Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat [PDF]
, 1990 Carlo Polidori +5 more
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Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data
Oral Diseases, EarlyView.ABSTRACT Objective Neuropsychiatric disorders are associated with poor oral health, with antipsychotics as potential contributors. This study aimed to analyse the oral adverse effects of antipsychotics using the EudraVigilance database. Methods A case/noncase analysis was conducted to calculate reporting odds ratios (ROR) and assess the ...
Leire Urien +5 more
wiley +1 more source
The possible mechanisms of protocatechuic acid-induced central analgesia
Saudi Pharmaceutical Journal, 2018 It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C, α2-adrenergic and muscarinic receptors in protocatechuic acid-induced central analgesia in mice ...
Rana Arslan +3 more
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