Convulsant bicuculline modifies CNS muscarinic receptor affinity
BMC Neuroscience, 2006 Background Previous work from this laboratory has shown that the administration of the convulsant drug 3-mercaptopropionic acid (MP), a GAD inhibitor, modifies not only GABA synthesis but also binding of the antagonist [3H]-quinuclidinyl benzilate ([3H ...
Rodríguez de Lores Arnaiz Georgina +1 more
doaj +1 more source
Comparison of pneumonia incidence between long-acting muscarinic antagonist and inhaled corticosteroid plus long-acting beta agonist in patients with COPD. [PDF]
Sci Rep, 2023 Lee EG +8 more
europepmc +1 more source
Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists.
Chemical and Pharmaceutical Bulletin, 2000 A series of 5H-dibenz[b,f]azepine derivatives was prepared and evaluated for binding affinities to muscarinic receptors in vitro. Among them, compound 8 showed a high affinity for human recombinant M2 receptors (Ki=2.6 nm), a low affinity for M4 receptors (39-fold less than for M2 receptors) and a very low affinity for M1 and M3 receptors (119- and 112-
G R, Mandelli +5 more
openaire +3 more sources
Spreading depolarization and its influence on epileptiform activity
Epilepsia, EarlyView.Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque +2 more
wiley +1 more source
Cholinergic neurons in the dorsomedial hypothalamus regulate food intake
Molecular Metabolism, 2017 Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong +2 more
doaj +1 more source
Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease. [PDF]
Cochrane Database Syst Rev, 2023 Fukuda N +6 more
europepmc +1 more source
Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults with asthma [PDF]
, 2015 David Evans +3 more
openalex +1 more source
Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale
Geriatrics &Gerontology International, EarlyView.ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi +4 more
wiley +1 more source
Hypertensive Urgency after Administration of a Single Low Dose of Mirtazapine- A Case Report
Iranian Journal of Public Health, 2015 Mirtazapine is a new antidepressant that can increase noradrenergic and serotonergic neurotransmission. It is also a postsynaptic antagonist of 5-HT2 and 5-HT3.
Jiana Shi +4 more
doaj
Coadministration of Galanin Antagonist M40 with a Muscarinic M1Agonist Improves Delayed Nonmatching to Position Choice Accuracy in Rats with Cholinergic Lesions [PDF]
, 1998 Michael P. McDonald +3 more
openalex +1 more source