Results 131 to 140 of about 52,496 (299)

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

The efficacy and safety of additional treatment with short-acting muscarinic antagonist combined with long-acting beta-2 agonist in stable patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. [PDF]

Chron Respir Dis, 2023
Tanimura K, Sato S, Fujita Y, Yamamoto Y, Hajiro T, Horita N, Kawayama T, Muro S.   +7 more
europepmc   +1 more source

Pharmacokinetics and Safety of a Single Subcutaneous or Intramuscular Dose of Ketamine in Healthy Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel, Debra C. Sellon, Macarena G. Sanz, Erin Pinnell, Zuzanna M. Pietras, Nicolas F. Villarino   +5 more
wiley   +1 more source

Treatment Patterns, Healthcare Utilization and Clinical Outcomes of Patients with Chronic Obstructive Pulmonary Disease Initiating Single-Inhaler Long-Acting β₂-Agonist/Long-Acting Muscarinic Antagonist Dual Therapy in Primary Care in England. [PDF]

Int J Chron Obstruct Pulmon Dis, 2023
Requena G, Banks V, Czira A, Wood R, Tritton T, Wild R, Compton C, Ismaila AS.   +7 more
europepmc   +1 more source

ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]

, 1980
David A. Brown, A. FORWARD, S. Marsh
openalex   +1 more source

Biomarkers to Predict Response to Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists in Adolescents and Adults with Mild Persistent Asthma

, 2021
Jerry A. Krishnan, Stephen C. Lazarus, Kathryn Blake, Christine A. Sorkness, Ronina Covar, Anne‐Marie Dyer, Jason E. Lang, Njira Lugogo, David T. Mauger, Michael E. Wechsler, Sally E. Wenzel, Juan Carlos Cardet, Mario Castro, Elliot Israel, Wanda Phipatanakul, Tonya S. King   +15 more
openalex   +2 more sources

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, EarlyView.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

Molecular mechanism of human α1A-adrenoceptor inhibition by Mamba snake toxin AdTx1

Communications Biology
There is growing interest in peptide or small protein based drugs targeting G protein-coupled receptors (GPCRs) for improved subtype selectivity over small molecules. Naturally occurring toxins represent rich sources of such ligands.
Mingyu Shi, Shuhao Zhang, Angqi Zhu, Yosuke Toyoda, Fang Kong, Xiaoou Sun, Xinyu Xu, Chuangye Yan, Xiangyu Liu   +8 more
doaj   +1 more source

Role of the thalamic parafascicular nucleus cholinergic system in the modulation of acute corneal nociception in rats [PDF]

Veterinary Research Forum, 2011
The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic
Esmaeal Tamaddonfard, Amir-Abbas Farshid, Sona Seiednejhad, Asghar Morvaridi   +3 more
doaj  

EFFECTS OF CERTAIN MUSCARINIC ANTAGONISTS ON THE ACTIONS OF ANTICHOLINESTERASES ON CAT SKELETAL MUSCLE [PDF]

, 1979
R.W. Brimblecombe, Mary C. French, Sandra N. Webb   +2 more
openalex   +1 more source