Results 131 to 140 of about 27,985 (262)

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

, 1990
Eleonora Kurtenbach, C.A.M. Curtis, E.K. Pedder, A. Aitken, Alona Harris, Edward C. Hulme   +5 more
openalex   +1 more source

From Design to Outcome: The Role of Bi‐ and Multifunctional Ligands in Modern Therapeutics

Advanced Therapeutics, Volume 8, Issue 10, October 2025.
This review highlights the innovative use of bi‐ and multifunctional ligands for precision therapeutics. From strategic linker design to bioorthogonal conjugation and nanoscaffold integration, these approaches enable precise targeting, high‐resolution receptor mapping, and enhanced drug delivery.
Célia Bouacha, Séverine Denoyelle, Sonia Cantel   +2 more
wiley   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea‐pigs

, 1994
Chien‐Huang Lin, Gwo‐Jyh Chang, Ming‐Jai Su, Yang‐Chang Wu, Che‐Ming Teng, Feng‐Nien Ko   +5 more
openalex   +1 more source

Modeling presynaptic inhibition by the amyloid precursor protein demonstrates one potential mechanism for preventing runaway synaptic modification in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Previous simulations of Hebbian associative memory models inspired the malignant synaptic growth hypothesis of Alzheimer's disease (AD), which suggests that cognitive impairments arise due to runaway synaptic modification resulting from poor separation between encoding and retrieval.
Dylan Barber, Michael E. Hasselmo, Heather C. Rice   +2 more
wiley   +1 more source

Pediatric Anesthetic Management of a Patient With Warburg Micro Syndrome, a Rare Autosomal Recessive Genetic Disorder

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Warburg micro syndrome is an extremely rare autosomal recessive genetic disorder with only 100 families documented worldwide. We present a safe and successful anesthetic management of a pediatric patient with Warburg micro syndrome utilizing total intravenous anesthesia (TIVA) and incisional Exparel.
Esha Thakkar, Michael McNally, Adrienne Hutton, Michael Holdeman, David G. Jackson   +4 more
wiley   +1 more source

Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis. [PDF]

BMC Pulm Med, 2020
Donohue JF, Kerwin E, Barnes CN, Moran EJ, Haumann B, Crater GD.   +5 more
europepmc   +1 more source

Differential control of human cardiac β-adrenergic and muscarinic receptors by chronic β-adrenoceptor antagonist treatment

, 1990
Shigeru Motomura, Otto‐Erich Brodde
openalex   +1 more source