Results 131 to 140 of about 2,979 (198)
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Discovering Antagonists in Networks of Systems: Robot Deployment [PDF]
arXivA contextual anomaly detection method is proposed and applied to the physical motions of a robot swarm executing a coverage task. Using simulations of a swarm's normal behavior, a normalizing flow is trained to predict the likelihood of a robot motion within the current context of its environment.
arxiv
Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction
Neurogastroenterology &Motility, EarlyView.Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley +1 more source
Neurogastroenterology &Motility, EarlyView.Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz +4 more
wiley +1 more source
Tolterodine and its Active 5‐Hydroxymethyl Metabolite: Pure Muscarinic Receptor Antagonists [PDF]
, 2002 Lisbeth Nilvebrant
openalex +1 more source
Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility
Neurogastroenterology &Motility, EarlyView.ABSTRACT This review focuses on mechanosensitive enteric neurons (MEN) in the guinea pig stomach and their roles in gastric motor reflex pathways. The guinea pig model is advantageous for studying gastric physiology, as its stomach structure and function closely resemble those of humans. Gastric motility involves distinct functional regions: the fundus
Gemma Mazzuoli‐Weber +2 more
wiley +1 more source
Migrastatin Acts as a Muscarinic Acetylcholine Receptor Antagonist [PDF]
, 2006 Koichi Nakae +3 more
openalex +1 more source
Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light
Neurogastroenterology &Motility, EarlyView.Optogenetic stimulation enables direct and selective stimulation of smooth muscle cells and thus provides a new opportunity to restore gastric contractility in cases of gastroparesis. Herein, we demonstrate that hOPN5 is a new and effective tool acting via Gq signaling and is thus complementary to light‐induced membrane depolarization with ...
David Zipf +6 more
wiley +1 more source
International Journal of COPD, 2019 Charlie Strange,1 Valery Walker,2 Michael DePietro,3 Junliang Tong,2 Jonathan Kurlander,2 Maureen Carlyle,2 Lauren A Millette,3 Eric Wittbrodt41Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA ...
Strange C +7 more
doaj