Results 131 to 140 of about 556,071 (288)

Methacholine hyperresponsiveness in mice with house dust mite‐induced lung inflammation is not associated with excessive airway constriction ex vivo

Experimental Physiology, EarlyView.
Abstract The role of excessive airway constriction in the hyperresponsiveness to nebulized methacholine in mice with experimental asthma is still contentious. Yet, there have been very few studies investigating whether the increased in vivo response to methacholine caused by experimental asthma is associated with a corresponding increase in ex vivo ...
Andrés Rojas‐Ruiz, Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Percival Graham, Jorge Soliz, Ynuk Bossé   +7 more
wiley   +1 more source

Characterization of the muscarinic receptor subtype(s) mediating contraction of the guinea‐pig lung strip and inhibition of acetylcholine release in the guinea‐pig trachea with the selective muscarinic receptor antagonist tripitramine [PDF]

, 1997
Ad F. Roffel, Joost H. Davids, Carolina R.S. Elzinga, Doris Wolf, Johan Zaagsma, H. Kilbinger   +5 more
openalex   +1 more source

Endothelial TRPV4–Cx43 signalling complex regulates vasomotor tone in resistance arteries

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we investigate, for the first time, the role of endothelial Cx43 hemichannels (hCx43) in the regulation of vasomotor tone. We discovered that TRPV4 channels and Cx43 are in proximity within the endothelium of mouse arterioles.
Pía C. Burboa, Pablo S. Gaete, Ping Shu, Priscila A. Araujo, Annie V. Beuve, Walter N. Durán, Jorge E. Contreras, Mauricio A. Lillo   +7 more
wiley   +1 more source

Patient considerations in the treatment of COPD: focus on the new combination inhaler umeclidinium/vilanterol

Patient Preference and Adherence, 2015
Timothy E Albertson,1–3 Richart Harper,1,2 Susan Murin,1,2 Christian Sandrock1 1Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA;
Albertson TE, Harper R, Murin S, Sandrock C   +3 more
doaj  

Effects of muscarinic agonists and antagonists on the negative chronotropic responses to the vagus nerve stimulation.

, 1979
Norifumi Yonehara, Kihachi Saito, Shuji Uchida, Yutaka Noguchi, Hiroshi Yoshida   +4 more
openalex   +1 more source

Efficacy and safety of long-acting β-agonist/long-acting muscarinic antagonist combinations in COPD: a network meta-analysis

Thorax, 2015
Y. Oba, Siva T Sarva, S. Dias
semanticscholar   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 901-913, July 2025.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Effects of the Selective M1 Muscarinic Receptor Antagonist Dicyclomine on Emotional Memory [PDF]

, 2000
Raquel Vecchio Fornari, Karin Di Monteiro Moreira, Maria Gabriela Menezes Oliveira   +2 more
openalex   +1 more source

Neuron‐Derived Extracellular Vesicles: Emerging Biomarkers and Functional Mediators in Alzheimer's Disease, With Comparative Insights Into Neurodevelopment and Aging

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurodegenerative disorders characterized by the accumulation of amyloid‐β (Aβ) peptide and phosphorylated tau protein in the brain. Despite intensive efforts, early diagnosis and monitoring of AD remain challenging due to the lack of reliable biomarkers that can detect the disease in its ...
Ceren Perihan Gonul, Bilge Karacicek, Sermin Genc   +2 more
wiley   +1 more source

Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory

Hippocampus, Volume 35, Issue 4, July 2025.
ABSTRACT Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). These pathologies are often presented together in the elderly and share some pathophysiological mechanisms.
Laura Pinedo‐Vargas, Felipe Mendez‐Salcido, Jonathan‐Julio Lorea‐Hernández, Victor de Lafuente, Fernando Peña‐Ortega   +4 more
wiley   +1 more source