Results 141 to 150 of about 556,071 (288)

Long‐acting muscarinic antagonist + long‐acting beta agonist versus long‐acting beta agonist + inhaled corticosteroid for COPD: A systematic review and meta‐analysis

Respirology (Carlton South. Print), 2015
N. Horita, N. Miyazawa, K. Tomaru, Miyo Inoue, T. Kaneko   +4 more
semanticscholar   +1 more source

The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer

MedComm, Volume 6, Issue 7, July 2025.
Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou, Jinzuo Jiang, Yangtao Xue, Xiaoqi Jiang, Yongzhuo Jiang, Peng Xiao, Junjie Xu   +6 more
wiley   +1 more source

Alterations in intracellular transduction systems coupled with muscarinic receptor following long-term exposure to muscarinic antagonists

, 1989
Masataka Kishi, Seitaro Ohkuma, Fu-Hi Ma, Kinya Kuriyama   +3 more
openalex   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

, 1990
Eleonora Kurtenbach, C.A.M. Curtis, E.K. Pedder, A. Aitken, Alona Harris, Edward C. Hulme   +5 more
openalex   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis. [PDF]

BMC Pulm Med, 2020
Donohue JF, Kerwin E, Barnes CN, Moran EJ, Haumann B, Crater GD.   +5 more
europepmc   +1 more source

Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea‐pigs

, 1994
Chien‐Huang Lin, Gwo‐Jyh Chang, Ming‐Jai Su, Yang‐Chang Wu, Che‐Ming Teng, Feng‐Nien Ko   +5 more
openalex   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source