Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Nα-nitro L-arginine methylester and other alkyl esters of L-arginine are muscarinic antagonists
, 1992 Dennis J. Cheek +3 more
openalex +1 more source
Sleep-Predominant Lowering of Ambulatory Blood Pressure by Bedtime Inhalation of a Novel Muscarinic M3 Receptor Antagonist: A New “Bronchoantihypertensive” Strategy Targeting the Lung in Hypertension with Chronic Obstructive Pulmonary Disease [PDF]
, 2008 Kazuomi Kario +2 more
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source
Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study. [PDF]
Clin Pharmacol Drug Dev, 2020 Borin MT +5 more
europepmc +1 more source
A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning [PDF]
, 2009 Douglas J. Sheffler +14 more
openalex +1 more source
Feed‐induced hypersalivation in horses from Austria, Germany and Switzerland
Equine Veterinary Journal, Volume 57, Issue 4, Page 1035-1043, July 2025.Abstract Background While previous reports come mostly from the southern Americas, several outbreaks of hypersalivation in horses were observed in Middle Europe from 2016 to 2018. Objective To describe feed‐induced hypersalivation in European horses. Study design Analysis of feedstuffs.
Linda Franziska Böswald +5 more
wiley +1 more source
Cholinergic neurons in the dorsomedial hypothalamus regulate food intake
Molecular Metabolism, 2017 Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong +2 more
doaj
inhibitor 2-[(4-methylphenyl)sulfonylcarbamido]-1-(4-nitrobenzyl)pyridinium bromide (2-AP27) is a muscarinic M2 receptor antagonist [PDF]
, 2009 Vytenis Arvydas Skeberdis +4 more
openalex +1 more source
Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility
Neurogastroenterology &Motility, Volume 37, Issue 7, July 2025.ABSTRACT This review focuses on mechanosensitive enteric neurons (MEN) in the guinea pig stomach and their roles in gastric motor reflex pathways. The guinea pig model is advantageous for studying gastric physiology, as its stomach structure and function closely resemble those of humans. Gastric motility involves distinct functional regions: the fundus
Gemma Mazzuoli‐Weber +2 more
wiley +1 more source