Results 71 to 80 of about 2,979 (198)
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Medicinal Research Reviews, EarlyView.ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva +5 more
wiley +1 more source
β3‐Adrenoceptor Agonist Effects on the Urinary Bladder Beyond Detrusor Relaxation
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims β3‐Adrenoceptor agonists such as mirabegron or vibegron reach pharmacokinetic steady‐state within a few days. However, maximum improvements in symptoms of the overactive bladder syndrome are reached at time points later than 4 weeks, that is, detrusor smooth muscle relaxation cannot fully explain clinical effects.
Martin C. Michel +2 more
wiley +1 more source
Data in Brief, 2019 This article contains information on the experimental design and methods on how the safety and tolerability data concerning patients with moderate to very severe chronic obstructive pulmonary disease (COPD) were obtained.
James Donohue +8 more
doaj
International Journal of COPD, 2015 Sanjeevan Muruganandan,1 Lata Jayaram2,3 1Department of Respiratory and Sleep Medicine, Austin Health, 2Department of Respiratory and Sleep Medicine, Western Health, 3University of Melbourne, Melbourne, Victoria, Australia Abstract: Chronic obstructive
Muruganandan S, Jayaram L
doaj
PLoS ONE, 2019 Pilocarpine is an M3 muscarinic agonist that is widely used for the treatment of xerostomia caused by various diseases and medical conditions. Pilocarpine induced the secretion of salivary fluid in perfused submandibular glands of rats.
Takanori Narita +3 more
doaj +1 more source
Pulmonary Therapy, 2020 Introduction In pediatric patients with asthma, measurements of forced expiratory volume in 1 s (FEV1) may be normal or may not correlate with symptom severity.
Stanley J. Szefler +9 more
doaj +1 more source
How adaptation currents change threshold, gain and variability of neuronal spiking [PDF]
, 2013 Many types of neurons exhibit spike rate adaptation, mediated by intrinsic slow $\mathrm{K}^+$-currents, which effectively inhibit neuronal responses. How these adaptation currents change the relationship between in-vivo like fluctuating synaptic input, spike rate output and the spike train statistics, however, is not well understood.
arxiv +1 more source
Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Background Metformin shows potential in combating clozapine‐induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine‐treated patients and its impact on weight and waist circumference (WC).
Bee Leng Per +5 more
wiley +1 more source
Turbulent mixing controls fixation of growing antagonistic populations [PDF]
PNAS 122 (7) e2417075122 (2025)Unlike coffee and cream that homogenize when stirred, growing micro-organisms (e.g., bacteria, baker's yeast) can actively kill each other and avoid mixing. How do such antagonistic interactions impact the growth and survival of competing strains, while being spatially advected by turbulent flows? By using numerical simulations of a continuum model, we
arxiv +1 more source
Head‐To‐Head Comparison of Biologic Efficacy in Asthma: What Have We Learned?
Allergy, EarlyView.ABSTRACT We performed an in‐depth appraisal of indirect head‐to‐head comparisons of biologics approved for asthma, including anti‐IL5/5Rα (mepolizumab, benralizumab), anti‐IL4Rα (dupilumab), anti‐TSLP (tezepelumab) and anti‐IgE (omalizumab), which was neither a systematic review nor a meta‐analysis.
Brian J. Lipworth +4 more
wiley +1 more source