Results 71 to 80 of about 27,985 (262)

Pilocarpine induces the residual secretion of salivary fluid in perfused submandibular glands of rats.

PLoS ONE, 2019
Pilocarpine is an M3 muscarinic agonist that is widely used for the treatment of xerostomia caused by various diseases and medical conditions. Pilocarpine induced the secretion of salivary fluid in perfused submandibular glands of rats.
Takanori Narita, Bing Qi, Masataka Murakami, Hiroshi Sugiya   +3 more
doaj   +1 more source

Stereoselectivity of the interaction of muscarinic antagonists with their receptors.

Trends in pharmacological sciences, 1989
info:eu-repo/semantics ...
Waelbroeck, Magali, Tastenoy, Michèle, Camus, Jean Claude, Feifel, Roland, Mutschler, Ernst, Tacke, Reinhold, Lambrecht, Günter, Christophe, Jean, Strohmann, Carsten   +8 more
openaire   +2 more sources

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Forced Expiratory Flow (FEF25–75%) as a Clinical Endpoint in Children and Adolescents with Symptomatic Asthma Receiving Tiotropium: A Post Hoc Analysis

Pulmonary Therapy, 2020
Introduction In pediatric patients with asthma, measurements of forced expiratory volume in 1 s (FEV1) may be normal or may not correlate with symptom severity.
Stanley J. Szefler, Stanley Goldstein, Christian Vogelberg, George W. Bensch, John Given, Branko Jugovic, Michael Engel, Petra M. Moroni-Zentgraf, Ralf Sigmund, Eckard H. Hamelmann   +9 more
doaj   +1 more source

Effect of the Arg16Gly β2‐Adrenergic Receptor Polymorphism on Long‐Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype‐Stratified, Multicenter Study

Allergy, EarlyView.
This study examines the association between the rs1042713 (Arg16Gly) polymorphism of the β2‐adrenergic receptor and the risk of severe eosinophilic asthma, as well as its influence on mepolizumab long‐term effectiveness and clinical remission. The Arg16 allele is associated with increased risk of severe disease and potentially diminished long‐term ...
Santi Nolasco, Evelina Fagone, Raffaele Campisi, Andrea Portacci, Giulia Scioscia, Corrado Pelaia, Angelantonio Maglio, Claudio Candia, Vitaliano Nicola Quaranta, Isabella Carrieri, Alessandro Saglia, Alessandro Vatrella, Girolamo Pelaia, Carlo Vancheri, Maria Pia Foschino Barbaro, Maria D'Amato, Giovanna Elisiana Carpagnano, Nunzio Crimi, Claudia Crimi, on behalf of the Southern Italy Network on Severe Asthma Therapy, Rossella Intravaia, Morena Porto, Pietro Impellizzeri, Maria Provvidenza Pistorio, Fabio Vignera, Andrea Alessia Nardo, Concetta Giannì, Silvano Dragonieri, Flogerta Sana, Valeria Pezzuto, Santina Ferulli, Massimo Triggiani, Roberta Parente, Pasquale Tondo, Piera Soccio, Donato Lacedonia, Luigi Ciampo, Antonio Franzese, Valeria Longobardi   +38 more
wiley   +1 more source

Genetics of infertility and “assisted fertilization” in the Bible: The case of Abraham and his family

Andrology, EarlyView.
Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni, Frank Tüttelmann, Livio Casarini   +2 more
wiley   +1 more source

Efficacy of interventions for myopia control in children: A systematic review with network meta‐analyses

Acta Ophthalmologica, EarlyView.
Abstract To determine the effectiveness of various interventions in reducing myopia progression in children. Literature databases were searched on December 2, 2023: PubMed, Embase, the Cochrane Central, Web of Science Core Collection, BIOSIS Previews, Current Contents Connect, Data Citation Index, Derwent Innovations Index, KCI‐Korean Journal Database,
Diana Chabané Schmidt, Anders Hvid‐Hansen, Nina Jacobsen, Trine Møldrup Jakobsen, Per Michael Larsen, Kjersti Kristin Lindblad, Flemming Møller, Annette Slyngborg, Yousif Subhi, Line Kessel   +9 more
wiley   +1 more source

Convulsant bicuculline modifies CNS muscarinic receptor affinity

BMC Neuroscience, 2006
Background Previous work from this laboratory has shown that the administration of the convulsant drug 3-mercaptopropionic acid (MP), a GAD inhibitor, modifies not only GABA synthesis but also binding of the antagonist [3H]-quinuclidinyl benzilate ([3H ...
Rodríguez de Lores Arnaiz Georgina, Schneider Patricia G   +1 more
doaj   +1 more source

The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents [PDF]

, 1977
Daniel Cavey, Jean‐Pierre Vincent, Michel Lazdunski   +2 more
openalex   +1 more source

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, EarlyView.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source