Results 81 to 90 of about 27,985 (262)

Cholinergic neurons in the dorsomedial hypothalamus regulate food intake

Molecular Metabolism, 2017
Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong, Dong Kun Lee, Young-Hwan Jo   +2 more
doaj   +1 more source

Comparison of pneumonia incidence between long-acting muscarinic antagonist and inhaled corticosteroid plus long-acting beta agonist in patients with COPD. [PDF]

Sci Rep, 2023
Lee EG, Kim Y, Hwang YI, Yoo KH, Lee SE, Jung KY, Lee D, Park YB, Rhee CK.   +8 more
europepmc   +1 more source

State‐dependent regulation of the Kv7.2 channel voltage sensor by QO‐58

British Journal of Pharmacology, EarlyView.
Background and Purpose KV7(KCNQ) potassium channels are key modulators of neuronal excitability, and promising targets for development of drugs for epilepsy and pain. We investigated a candidate KV7 drug, QO‐58, which has been previously described but has an unclear mechanism of action.
Richard Kanyo, Shawn M. Lamothe, Thomas M. Hammond, Harley T. Kurata   +3 more
wiley   +1 more source

Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease. [PDF]

Cochrane Database Syst Rev, 2023
Fukuda N, Horita N, Kaneko A, Goto A, Kaneko T, Ota E, Kew KM.   +6 more
europepmc   +1 more source

Effects of temperature and ethanol on agonist and antagonist binding to rat heart muscarinic receptors in the absence and presence of GTP [PDF]

, 1985
Magalì Waelbroeck, Patrick Robberecht, Pierre Chatelain, Philippe De Neef, Jean Christophe   +4 more
openalex   +1 more source

Mechanisms of the antinociceptive action of (−) Epicatechin obtained from the hydroalcoholic fraction of Combretum leprosum Mart & Eic in rodents

Journal of Biomedical Science, 2012
Background The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher.
Lopes Luciano da, Marques Rosemarie, Fernandes Heliana, Pereira Sergio da, Ayres Mariane CC, Chaves Mariana, Almeida Fernanda RC   +6 more
doaj   +1 more source

ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]

, 1980
David A. Brown, A. FORWARD, S. Marsh
openalex   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Hypertensive Urgency after Administration of a Single Low Dose of Mirtazapine- A Case Report

Iranian Journal of Public Health, 2015
Mirtazapine is a new antidepressant that can increase noradrenergic and serotonergic neurotransmission. It is also a postsynaptic antagonist of 5-HT2 and 5-HT3.
Jiana Shi, Xiaojun Wang, Yin Ying, Lin Xu, Danyan Zhu   +4 more
doaj  

The efficacy and safety of additional treatment with short-acting muscarinic antagonist combined with long-acting beta-2 agonist in stable patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. [PDF]

Chron Respir Dis, 2023
Tanimura K, Sato S, Fujita Y, Yamamoto Y, Hajiro T, Horita N, Kawayama T, Muro S.   +7 more
europepmc   +1 more source