Results 251 to 260 of about 687,004 (308)

Muscarinic receptor antagonists for the treatment of chronic obstructive pulmonary disease

Expert Opinion on Pharmacotherapy, 2014
M. Matera, P. Rogliani, M. Cazzola
semanticscholar   +1 more source

Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease

Expert Opinion on Investigational Drugs, 2010
G. Joos
semanticscholar   +1 more source

Long-acting muscarinic M3 receptor antagonists.

Expert opinion on therapeutic patents, 2010
A series of 10 closely related patent applications define Theravance's approach to the development of long-acting M(3) selective antagonists for the treatment of chronic obstructive pulmonary disease. The applications illustrate a modular approach to the design of such agents, comprising a muscarinic pharmacophore attached to a second, less ...
openaire   +2 more sources

Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs

Journal of Pharmacology and Experimental Therapeutics, 2009
P. Casarosa, T. Bouyssou, S. Germeyer, A. Schnapp, F. Gantner, M. Pieper   +5 more
semanticscholar   +1 more source

Comparison of Receptor Binding Characteristics of Commonly Used Muscarinic Antagonists in Human Bladder Detrusor and Mucosa

Journal of Pharmacology and Experimental Therapeutics, 2009
K. Mansfield, J. Chandran, K. Vaux, R. Millard, A. Christopoulos, F. Mitchelson, E. Burcher   +6 more
semanticscholar   +1 more source

Muscarinic receptor antagonists

Reactions Weekly, 2015
openaire   +1 more source

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[

Journal of Medicinal Chemistry, 2009
M. Prat, D. Fernández, M. A. Buil, M. I. Crespo, Gaspar Casals, Manel Ferrer, L. Tort, Jordi Castro, J. M. Monleón, A. Gavaldà, M. Miralpeix, I. Ramos, T. Doménech, Dolors Vilella, F. Antón, J. M. Huerta, S. Espinosa, M. López, Sònia Sentellas, Marisa González, J. Albertí, V. Segarra, Alvaro Cárdenas, J. Beleta, H. Ryder   +24 more
semanticscholar   +1 more source

Long-acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease

Expert Review of Clinical Pharmacology, 2010
Dramane I. Lainé
semanticscholar   +1 more source

Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats.

Neuroscience, 1997
M. Vannucchi, C. Scali, S. Kopf, G. Pepeu, F. Casamenti   +4 more
semanticscholar   +1 more source

Dual-acting beta2 agonists/muscarinic antagonists.

Expert opinion on therapeutic patents, 2010
Bifunctional aromatic derivatives that act as both beta(2) agonists and muscarinic receptor antagonists are claimed. The compounds use two separate pharmacophoric groups, coupled by a long lipohilic chain, to provide the desired biological activities and with the aim of providing a long duration of action.
openaire   +1 more source