Results 61 to 70 of about 25,052 (251)

Oscillometric assessment of bronchodilator response in horses with severe asthma during remission

Equine Veterinary Journal, EarlyView.
Abstract Background During clinical remission of severe equine asthma (SEA), affected animals can be challenging to distinguish from healthy horses. In humans, the degree of bronchodilation achieved with a β2‐adrenergic bronchodilator is helpful in differentiating asthmatics from healthy subjects.
Séléna de Wasseige, Sophie Mainguy‐Seers, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

The effects of oral administration of the novel muscarinic receptor antagonist DA-8010 on overactive bladder in rat with bladder outlet obstruction

BMC Urology, 2020
Background DA-8010 is a novel compound developed for the treatment of overactive bladder (OAB) and urinary incontinence. The aims of this study were to investigate the effects of DA-8010 on OAB in a rat model.
Jin Bong Choi, Seung Hwan Jeon, Eun Bi Kwon, Woong Jin Bae, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim   +8 more
doaj   +1 more source

Long-Term Efficacy of Mirabegron Add-On Therapy to Antimuscarinic Agents in Patients With Spinal Cord Injury [PDF]

Annals of Rehabilitation Medicine, 2019
Objective To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study.
Seok-Hee Han, In Kyoung Cho, Joo Hwan Jung, Seong Ho Jang, Bum-Suk Lee   +4 more
doaj   +1 more source

Low‐Concentration Dopamine Potentiates Gastric Motility Through Activation of Dopamine D5 Receptor on Enteric Cholinergic Neurons

Gut Medicine, EarlyView.
ABSTRACT Background Dopamine (DA) exerts complex concentration‐dependent effects on gastrointestinal motility. Although its inhibitory action through D2‐like receptors is well‐established, the mechanisms underlying its excitatory effects remain elusive.
Xiao‐Li Zhang, Tuo Ji, Yue Zhang, Cai‐Feng Zhang, Yun‐Jing Bai, Jin Song   +5 more
wiley   +1 more source

A new class of irreversible muscarinic antagonists: β-haloethylamine furoates

, 1976
The synthesis of a new class of ultra-long acting muscarinic antagonists is described. Furthermore, it is noted that the stability of the, in situ, aziridinium ion is sufficiently great so that these agents can be used to study the effect of temperature ...
Gerald M Rosen, Elmer J Rauckman
core   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Constitutive activity of the M1–M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists

, 1995
We investigated whether muscarinic receptors of the M1–M4 receptor subtypes are constitutively active. We have found that the synthesis of cyclic AMP was enhanced by the muscarinic antagonists atropine and N-methylscopolamine (NMS) in Chinese hamster ...
Jakubík, Jan, Bačáková, Lucie, Tuček, Stanislav, Lucie Bačáková, Stanislav Tuček, Jan Jakubík, Esam E. El-Fakahany, El-Fakahany, Esam E.   +7 more
core   +1 more source

The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease [PDF]

, 2014
Muscarinic receptor antagonists and β-adrenoceptor agonists are used in the treatment of obstructive airway disease and overactive bladder syndrome. Here we review the pharmacological rationale for their combination.
Schmidt, Martina, Dale, Philippa R, Dowling, Mark R, Michel, Martin C, Dowling, Mark R., Pieper, Michael P., Dale, Philippa R., Michel, Martin C., Cernecka, Hana, Charlton, Steven J., Pieper, Michael P, Charlton, Steven J, Schmidt, Martina; id_orcid   +12 more
core   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions

Cell Reports, 2019
Summary: Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and the pathogenesis of tumor progression. We investigated the innervation of LVs and the response to agonists and antagonists of the autonomic nervous system in 
Samia B. Bachmann, Denise Gsponer, Javier A. Montoya-Zegarra, Martin Schneider, Felix Scholkmann, Carlotta Tacconi, Simon F. Noerrelykke, Steven T. Proulx, Michael Detmar   +8 more
doaj   +1 more source