Results 101 to 110 of about 8,830 (256)

Variability in the Drug Response of M4 Muscarinic Receptor Knockout Mice During Day and Night Time

Frontiers in Pharmacology, 2019
Mice are nocturnal animals. Surprisingly, the majority of physiological/pharmacological studies are performed in the morning, i.e., in the non-active phase of their diurnal cycle.
Paulina Valuskova, Vladimir Riljak, Sandor T. Forczek, Vladimir Farar, Jaromir Myslivecek   +4 more
doaj   +1 more source

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor [PDF]

, 2014
Background: BQCA is a selective allosteric modulator of the M1 mAChR. Results: Residues that govern BQCA activity were identified using mutagenesis and molecular modelling.
Abdul-Ridha, Avlani, Ballesteros, Black, Canals, Cherezov, Choe, Christopoulos, Conn, Conn, Daval, Davie, De Amici, Dror, Duan, Goodwin, Haga, Huang, Hulme, Hulme, Kenakin, Kruse, Lagerström, Leach, Leach, Leach, Lebois, Lebon, Lu, Lu, Ma, Marquer, Matsui, May, May, Miao, Mistry, Motulsky, Nawaratne, Nawaratne, Phillips, Prilla, Rasmussen, Rasmussen, Sali, Shirey, Shonberg, Spalding, Stevens, Tan, Thompson, Valant, Valant, Valentin-Hansen, Venkatakrishnan, Voigtländer, Wacker, Wang   +57 more
core   +2 more sources

Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data

Oral Diseases, Volume 31, Issue 8, Page 2630-2640, August 2025.
ABSTRACT Objective Neuropsychiatric disorders are associated with poor oral health, with antipsychotics as potential contributors. This study aimed to analyse the oral adverse effects of antipsychotics using the EudraVigilance database. Methods A case/noncase analysis was conducted to calculate reporting odds ratios (ROR) and assess the ...
Leire Urien, Unax Lertxundi, Montserrat Garcia, Carmelo Aguirre, Nerea Jauregizar, Teresa Morera‐Herreras   +5 more
wiley   +1 more source

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

BMC Cell Biology, 2005
Background Recent studies indicate that the G protein-coupled receptor (GPCR) signaling machinery can serve as a direct target of reactive oxygen species, including nitric oxide (NO) and S-nitrosothiols (RSNOs).
Mönkkönen Kati S, Savinainen Juha R, Kokkola Tarja, Retamal Montse, Laitinen Jarmo T   +4 more
doaj   +1 more source

Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
core   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling [PDF]

, 2017
Satiety, rather than all or none, can instead be viewed as a cumulative decrease in the drive to eat that develops over the course of a meal. The nucleus accumbens (NAc) is known to play a critical role in this type of value reappraisal, but the ...
Aitta-aho, Teemu Heikki Juhani, Apergis-Schoute, John, Bussey, Tim J., Harnischfeger, Fiona, Hay, Y. Adrey, Heath, Christopher, Pappa, Elpiniki, Phillips, Benjamin U., Saksida, Lisa M.   +8 more
core   +2 more sources

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia

Frontiers in Psychiatry
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with ...
Samantha E. Yohn, Phillip D. Harvey, Stephen K. Brannan, William P. Horan, William P. Horan   +4 more
doaj   +1 more source

Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

Frontiers in Molecular Neuroscience, 2018
The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive.
Anna M. Klawonn, Anna M. Klawonn, Daniel B. Wilhelms, Daniel B. Wilhelms, Sarah H. Lindström, Anand Kumar Singh, Anand Kumar Singh, Maarit Jaarola, Jürgen Wess, Michael Fritz, Michael Fritz, David Engblom   +11 more
doaj   +1 more source