Results 111 to 120 of about 8,830 (256)

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior [PDF]

, 2016
Current antipsychotics are effective in treating the positive symptoms associated with schizophrenia, but they remain suboptimal in targeting cognitive dysfunction.
Arthur Christopoulos, Bakshi, Christopher J. Langmead, Christos Pantelis, Daniel T. Malone, David M. Shackleford, Johnathan R. Lane, Kwok H. C. Choy, Lee, Matsuo, Pantelis, Patrick M. Sexton, Peter J. Scammells, Rahul T. Patil, Shailesh N. Mistry   +14 more
core   +1 more source

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit [PDF]

, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Acsády, Ahumada, Aizawa, Akam, Alkondon, Andrade, Andrade, Aznar, Bacon, Barnes, Beck, Berumen, Bijak, Bliss, Bombardi, Brandalise, Bronzino, Buchanan, Bush, Cezar M. Tigaret, Chalmers, Chandler, Cheng, Chiang, Contractor, Cox, Danielson, Dasari, Domínguez, Domínguez, Donato, Etter, Fabian-Fine, Fischer, Frazier, Freund, Fuhs, Fukudome, Gahring, Gahring, Gangarossa, Gasbarri, Gasbarri, Gelinas, Gelinas, Giessel, Ginsberg, Giocomo, Goutagny, Gray, Griffith, Grishin, Grishin, Grybko, Grybko, Gulyás, Gundlfinger, Gundlfinger, Guo, Guzman, Haas, Haas, Hamilton, Hansen, Hansen, Hasselmo, Hasselmo, Hebb, Hofmann, Hofmann, Hofmann, Hopkins, Hopkins, Hu, Huang, Hummos, Hunsaker, Hunsaker, Hájos, Hörtnagl, Jack R. Mellor, Jacobs, Jerman, Jochems, Jochems, John, Jones, Jung, Jurgens, Karunakaran, Katsuki, Kheirbek, Kitt, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Kulla, Kunec, Kwon, Lacaille, Lee, Lemon, Lengyel, Lengyel, Leranth, Leutgeb, Levey, Li, Liotta, Lisman, Lisman, Losonczy, Luke Y. Prince, Luo, Lynch, Lüscher, Maccaferri, Madison, Madison, Maeda, Manuel-Apolinar, Marr, Martinello, Marín-Burgin, McHugh, McIntyre, McMahon, McNaughton, McQuiston, Meeter, Meeter, Millan, Milner, Milner, Mishra, Missale, Mistry, Miyawaki, Mlinar, Mohler, Mori, Mori, Müller, Nahir, Nakashiba, Nakashiba, Nakazawa, Nissen, Nolan, Nozaki, O'Reilly, Okuhara, Ondrejcak, Parfitt, Parfitt, Pazos, Pedarzani, Pelkey, Piguet, Puighermanal, Radcliffe, Ramos, Restivo, Romo-Parra, Rosen, Ruediger, Ruiz, Rüdiger, Salin, Sara, Saravanan, Sariñana, Savin, Scanziani, Scanziani, Scoville, Segal, Sharma, Sharma, Smith, Sodickson, Son, Squire, Straube, Suwa, Szabadics, Szabó, Takeuchi, Tang, Tigaret, Torborg, Toth, Travis J. Bacon, Treves, Treviño, Twarkowski, Tzounopoulos, Törk, Ul Haq, Ul Haq, Vankov, Varga, Vilaró, Vilaró, Villani, Vogels, Vogt, Walling, Walling, Wang, Welsby, Welsby, West, Wiescholleck, Wilke, Williams, Williams, Yang, Yi, Zalutsky, Zhang   +221 more
core   +5 more sources

Activation of Muscarinic Acetylcholine Receptor Subtype 4 is Essential for Cholinergic Stimulation of Gastric Acid Secretion - Relation To D Cell/Somatostatin -

Frontiers in Pharmacology, 2016
Background/Aim: Muscarinic acetylcholine receptors exist in five subtypes (M1~M5), and they are widely expressed in various tissues to mediate diverse autonomic functions, including gastric secretion.
Koji Takeuchi, Koji Takeuchi, Takuya Endoh, Shusaku Hayashi, Takeshi Aihara   +4 more
doaj   +1 more source

Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis [PDF]

, 2023
Lidia Madrid San Martin, Katelyn Hafey, Saurabh Bandhavkar, Gabriela O. Bodea, Javier Jiménez-Martín, Michael Milne, Tara L. Walker, Geoffrey J. Faulkner, Elizabeth J. Coulson, Dhanisha J. Jhaveri   +9 more
openalex   +1 more source

Cholinergic and endocannabinoid neuromodulatory effects overlap on neurons of the pedunculopontine nucleus of mice [PDF]

, 2015
The pedunculopontine nucleus (PPN) is a part of the reticular activating system and one of the main sources of the cholinergic fibers in the midbrain, while it is also subject to cholinergic modulation.
Bordas, Csilla, Kovács, Adrienn, Pál, Balázs Zoltán   +2 more
core   +1 more source

Regulation of Src Family Tyrosine Kinases in the Rat Striatum by Muscarinic Acetylcholine Receptors [PDF]

, 2017
Acetylcholine is an important neurotransmitter in the mammalian brain. This transmitter binds to muscarinic acetylcholine receptors (mAChR) to regulate activity of a variety of intracellular signaling molecules.
Faris, Hunter
core  

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines [PDF]

, 2001
1. The pharmacological characteristics of the presynaptic muscarinic receptor subtype, which mediates inhibition of the neurogenic contractions in the prostatic portion of rabbit vas deferens, have been investigated by using a series of polymethylene ...
Bolognesi M. L., Budriesi R., Cacciaguerra S., Chiarini A., Di Toro R., Melchiorre C., Minarini A., Rosini M., Spampinato S., Tumiatti V.   +9 more
core   +1 more source

Novel aspects of cholinergic regulation of colonic ion transport [PDF]

, 2015
Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core   +1 more source

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia [PDF]

, 2015
Weixing Shen, Joshua L. Plotkin, Veronica Francardo, Wai Kin D. Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R. Neubig, Craig W. Lindsley, P. Jeffrey Conn, Paul Greengard, Erwan Bézard, M. Angela Cenci, D. James Surmeier   +14 more
openalex   +1 more source