Rationale for Selective Muscarinic Receptor Agonists as Candidates for the Management of Cognitive and Neuropsychiatric Symptoms in Alzheimer's Disease [PDF]
Alzheimers DementAbstract Background Cognitive impairment and neuropsychiatric symptoms, including psychosis, are fundamental features of Alzheimer's disease (AD) and related dementias. Currently treatments for these symptoms have efficacy, safety, and tolerability limitations; new treatments with novel mechanisms are needed.
Marcus R +4 more
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Structure of the m4 Cholinergic Muscarinic Receptor Gene and Its Promoter [PDF]
Journal of Biological Chemistry, 1995 Cholinergic muscarinic receptor genes are members of the G-protein receptor gene superfamily. In this study we describe the structure of the gene and promoter of the rat m4 muscarinic receptor gene. A rat cosmid clone containing the coding region for the m4 gene and 25 kilobases of upstream sequence was isolated.
Ian Wood +3 more
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Non‐clinical Efficacy and Safety of SUVN‐L3307032, a Muscarinic M4 Positive Allosteric Modulator (M4 PAM), for the Treatment of Neuropsychiatric Symptoms. [PDF]
Alzheimers DementAbstract Background Neuropsychiatric symptoms (NPS) associated with Alzheimer’s disease (AD) are burdensome to the caregiver and patients. The current therapies for the treatment of NPS in AD are associated with limited efficacy and severe side effects. Hence, newer treatment options are required to effectively control these symptoms.
Abraham R +17 more
europepmc +2 more sources
Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates. [PDF]
PLoS ONE, 2015 Cholinergic, muscarinic receptor agonists exhibit functional dopamine antagonism and muscarinic receptors have been suggested as possible future targets for the treatment of schizophrenia and drug abuse. The muscarinic ligand (5R,6R)-6-(3-butylthio-1,2,5-
Maibritt B Andersen +6 more
doaj +1 more source
Genetic linkage mapping of the m4 human muscarinic receptor (CHRM4) [PDF]
Genomics, 1992 Raji P. Grewal +5 more
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Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]
, 2018 The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J. +14 more
core +1 more source
Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype
Journal of Pharmacological Sciences, 2004 Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi +5 more
doaj +1 more source
Translational Psychiatry, 2023 Cognitive impairment is a predictor of disability across different neuropsychiatric conditions, and cognitive abilities are also strongly related to educational attainment and indices of life success in the general population.
Sara E. Jones, Philip D. Harvey
doaj +1 more source
Muscarinic M1 and M4 receptors: Hypothesis driven drug development for schizophrenia [PDF]
Psychiatry Research, 2020 The finding that the drug KarXT, a formulation of xanomeline and tropsium which targets muscarinic receptors, has given a positive result in reducing the positive and negative symptoms of schizophrenia in a phase II trial suggests targeting muscarinic receptors is a new approach to treating the disorder.
Dean, B, Scarr, E
openaire +3 more sources
Neurobiology of Disease, 2005 In this study, we investigated whether transient cerebral ischemia affects the function and molecular expression of specific muscarinic cholinergic receptors.
Guangming Zhang +6 more
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