Results 221 to 230 of about 55,054 (301)

Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016–2020

British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1727-1738, June 2025.
Abstract Aims Tricyclic antidepressants (TCAs) are commonly prescribed despite no longer being a NICE‐recommended first‐line treatment for depression and their recognized toxicity in overdose. This study examined prescribing, mortality, hospital admissions and clinical TCA data to quantify the use and impact of TCAs in England and Wales.
Laurence Gray, Michael Beddard, Stephen Jones, Asiyah Begum, Noraini B. Azhar, Paul Deslandes, James Coulson, Sally Bradberry, Euan A. Sandilands, Ruben H. Thanacoody, Matthew O. Ivory   +10 more
wiley   +1 more source

Interactions between the muscarinic receptors, sodium channels, and guanine nucleotide-binding protein(s) in rat atria.

, 1986
Malka Cohen‐Armon, Mordechai Sokolovsky   +1 more
openalex   +1 more source

The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 6, June 2025.
ABSTRACT Acute pancreatitis (AP) is a serious pancreatic inflammatory disease that results in pancreatic enzyme activation and autodegradation. Betulinic acid (BA), a pentacyclic triterpene of natural origin that was isolated from several plants, has anti‐inflammatory, immunomodulatory and antioxidant effects that can help with AP.
Guler Yenice, Seckin Ozkanlar, Ismail Bolat, Serkan Yildirim   +3 more
wiley   +1 more source

Batrachotoxin changes the properties of the muscarinic receptor in rat brain and heart: possible interaction(s) between muscarinic receptors and sodium channels.

, 1985
Malka Cohen‐Armon, Yoel Kloog, Yoav I. Henis, Mordechai Sokolovsky   +3 more
openalex   +1 more source

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats

British Journal of Pharmacology, Volume 182, Issue 11, Page 2487-2502, June 2025.
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra, Terence Appelqvist, Robert Lange, Maura Corsetti, Marcel Jimenez   +4 more
wiley   +1 more source

Growth Differentiation Factor 15 Induces Gastric Fundus Contraction Involving Cholinergic Excitation: Morphofunctional Evidence in Rodent Models

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Growth Differentiation Factor 15 (GDF15) is a peptide from the transforming growth factor (TGF)‐β superfamily, typically found at low levels in mammalian tissues, but significantly upregulated during cellular stress or injury. Initially recognised for its role in inducing anorexia and vomiting, GDF15 is now seen as a broader regulator of ...
Rachele Garella, Francesco Palmieri, Livio Tarchi, Alessia Tani, Flaminia Chellini, Giulia Guarnieri, Annamaria Morelli, Caterina Bernacchioni, Paolo Rovero, Valdo Ricca, Giovanni Castellini, Chiara Sassoli, Roberta Squecco   +12 more
wiley   +1 more source

Clinical Application Guideline of Combination With Traditional Chinese Medicine and Western Medicine in the Prevention and Treatment of Chronic Obstructive Pulmonary Disease (2024)

Journal of Evidence-Based Medicine, Volume 18, Issue 2, June 2025.
ABSTRACT Aim Chronic Obstructive Pulmonary Disease (COPD) is a common chronic airway disease that can lead to decreased lung function in patients. It places a heavy economic burden on patients and society. Traditional Chinese medicine (TCM) and Western medicine have played important roles in managing COPD.
Di Wu, Wei Liu, Jianxin Wang, Wei Chen, Mengyao Shi, Lu Zhang, Hui Wang, Huanzhang Ding, Xiao Ma, Yating Gao, Zengtao Sun, Jiangtao Lin, Hongchun Zhang, Suyun Li, Zhuying Li, Zhenhui Lu, Fuqiang Wen, Zegeng Li   +17 more
wiley   +1 more source

Recognition of the muscarinic receptor by its endogenous neurotransmitter: binding of [3H]acetylcholine and its modulation by transition metal ions and guanine nucleotides.

, 1984
David Gurwitz, Yoel Kloog, M Sokolovsky
openalex   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Rethinking Sensory Information Processing: The Essential Role of Astrocytes

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
In this review, we discuss recent advances highlighting the emerging roles of astrocytes in sensory information processing. We review how astrocytes are anatomically integrated within distinct sensory systems, how they are activated by specific external stimuli, and how their modulation influences the output of sensory neurons to shape behavioral ...
Juliana M. Rosa, Juan Aguilar
wiley   +1 more source