Results 31 to 40 of about 46,455 (160)

Delineating muscarinic receptor functions [PDF]

Proceedings of the National Academy of Sciences, 1999
Acetylcholine, as the first chemical molecule to be established as a neurotransmitter, has attracted enduring interest from researchers over several decades. However, deciphering all of the physiological manifestations associated with actions of this molecule has been difficult, and many mysteries of cholinergic neurotransmission still remain to be ...
R R, Gainetdinov, M G, Caron
openaire   +2 more sources

Increased expression of neuregulin 1 in the urothelium of rat bladder with partial bladder outlet obstruction

BMC Urology, 2017
Background This study determined whether changes in the expression of neuregulin (NRG) 1, erbB2 tyrosine kinase (ErbB2) and the M2 muscarinic receptor in the urothelium and detrusor muscle of the rat bladder were associated with partial bladder outlet ...
Seung Woo Yang, Seong Woo Jeong, Ki Hak Song   +2 more
doaj   +1 more source

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

Journal of Pharmacological Sciences, 2010
We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice.
Yukihito Tsukumo, Daisuke Harada, Haruhiko Manabe   +2 more
doaj   +1 more source

Identification, expression and functional characterization of M4L, a muscarinic acetylcholine M4 receptor splice variant. [PDF]

PLoS ONE, 2017
Rodent genomic alignment sequences support a 2-exon model for muscarinic M4 receptor. Using this model a novel N-terminal extension was discovered in the human muscarinic acetylcholine M4 receptor. An open reading frame was discovered in the human, mouse
Douglas A Schober, Carrie H Croy, Cara L Ruble, Ran Tao, Christian C Felder   +4 more
doaj   +1 more source

Two Types of Cation Channel Activated by Stimulation of Muscarinic Receptors in Guinea-Pig Urinary Bladder Smooth Muscle

Journal of Pharmacological Sciences, 2008
The present study, aiming to elucidate ion channel mechanisms underlying muscarinic receptor–induced depolarization, has characterized membrane currents induced by carbachol in single guinea-pig urinary bladder myocytes. Application of carbachol to cells
Masayuki Yamamoto, Toshihiro Unno, Hayato Matsuyama, Masanobu Kohda, Noriyuki Masuda, Masakazu Nishimura, Toshiaki Ishii, Seiichi Komori   +7 more
doaj   +1 more source

Spinal cord regeneration by modulating bone marrow with neurotransmitters and Citicholine: Analysis at micromolecular level

Biomedical Journal, 2017
Background: Spinal cord injury results in disruption of brain-spinal cord fibre connectivity, leading to progressive tissue damage at the site of injury and resultant paralysis of varying degrees.
Cheramadathukudiyil Skaria Paulose, Ponnezhathu Sebastian John, Romeo Chinthu, Puthenveetil Raju Akhilraj, Thoppil Raveendran Anju   +4 more
doaj   +1 more source

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

Advances in Pharmacological Sciences, 2009
In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve ...
Anders T. Ryberg, Ondrej Soukup, Gunnar Tobin   +2 more
doaj   +1 more source

Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

Journal of Pharmacological Sciences, 2018
The role of the GABAB receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABAB receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats.
Keisuke Migita, Yu Matsuzaki, Kohei Koga, Taichi Matsumoto, Kenichi Mishima, Shuji Hara, Kenji Honda   +6 more
doaj   +1 more source

A new nosology of psychosis and the pharmacological basis of affective and negative symptom dimensions in schizophrenia

Mental Illness, 2010
Although first rank symptoms focus on positive symptoms of psychosis they are shared by a number of psychiatric conditions. The difficulty in differentiating bipolar disorder from schizophrenia with affective features has led to a third category of ...
Costa Vakalopoulos
doaj   +1 more source

Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]

PLoS ONE, 2014
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow, Kelly Jiang, Alipi V Naydenov, Joshua H Le, Nephi Stella, Neil M Nathanson   +5 more
doaj   +1 more source