Results 121 to 130 of about 29,348 (182)
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Selective inactivation of muscarinic receptor subtypes
International Journal of Biochemistry, 1994Muscarinic receptors exist in multiple subtypes, denoted as M1, M2, M3 and M4, encoded by four distinct but related genes. A fifth gene product, m5, has also been predicted although this sequence awaits a pharmacological equivalent. Many tissues express more than one muscarinic receptor subtype, which may couple to different intracellular effectors and
R M, Eglen, H, Reddy, N, Watson
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Relationship between muscarinic acetylcholine receptor subtypes
HEREDITAS, 2007Muscarinic acetylcholine receptor belongs to the G-coupled receptor family, the cooperation between its five subtypes is crucially important in maintaining the normal physiological function. At present, many types of biological resources are increasing, which provides unprecedented opportunities to study the relationships between muscarinic ...
Hai-Long, Yu +4 more
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Muscarinic receptor subtypes in canine trachea
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1990Prejunctional and postjunctional muscarinic receptor subtypes were characterized in canine trachealis muscle strips. In vitro contractile responses of muscle strips to acetylcholine or electric field stimulation were determined in the absence and the presence of gallamine, pirenzepine, and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP ...
Brichant, Jean-François +3 more
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Human prostate muscarinic receptor subtypes.
The Journal of Pharmacology and Experimental Therapeutics, 1995The alpha adrenergic receptor subtypes of the human prostate have been intensively investigated, while the muscarinic receptor subtypes and their function have yet to be determined in this tissue. [3H]-QNB binding to muscarinic receptors was performed on membrane homogenates of adenoma from six prostatectomy specimens resulting in an average total ...
M R, Ruggieri +6 more
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Muscarinic receptor subtypes in airways
European Respiratory Journal, 1993Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release.
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Molecular distinction between muscarinic acetylcholine receptor subtypes
Nature, 1987The muscarinic acetylcholine receptor (mAChR) mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels, through the action of guanine nucleotide-binding regulatory proteins.
K, Fukuda +5 more
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Muscarinic receptor subtype in porcine coronary artery
European Journal of Pharmacology, 1988The specific binding of (-)-[3H]QNB (quinuclidinyl benzilate) in membrane fractions of porcine coronary artery was saturable, of high affinity and stereoselective. It has been shown that there exist (-)-[3H]QNB binding sites with high (Ki = 12 nM)- and low(Ki = 1010 nM)-affinity for pirenzepine in the coronary artery but predominantly low-affinity ...
S, Yamada +4 more
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Polymorphisms in Human Muscarinic Receptor Subtype Genes
2011A wide range of polymorphisms have been reported in muscarinic receptor subtype genes, mostly in M₁ and M₂ and, to a lesser extent, M₃ receptors. Most studies linking such genetic variability to phenotype have been performed for brain functions, but a more limited amount of information is also available for cardiac and airway function.
Michel, Martin C., Teitsma, Christine A.
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Pharmacological evidence for cardiac muscarinic receptor subtypes
Life Sciences, 1984The chronotropic and inotropic effects of muscarinic receptor agonists (Acetylcholine, Arecoline, Carbachol, Furtrethonium) and antagonists (Atropine, N-methyl and N-butyl scopolammonium, pirenzepine) on isolated guinea-pig atria were studied. All had a greater affinity constants for muscarinic receptors as assessed in terms of inotropic effects than ...
C, Chassaing +3 more
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Muscarinic receptor subtypes involved in hippocampal circuits
Life Sciences, 1999Muscarinic receptors modulate hippocampal activity in two main ways: inhibition of synaptic activity and enhancement of excitability of hippocampal cells. Due to the lack of pharmacological tools, it has not been possible to identify the individual receptor subtypes that mediate the specific physiological actions that underlie these forms of modulation.
S T, Rouse +4 more
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