Results 131 to 140 of about 29,348 (182)
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Muscarinic acetylcholine receptor subtypes in smooth muscle
Trends in Pharmacological Sciences, 1994Muscarinic acetylcholine M2 and M3 receptor subtypes are coexpressed in many types of smooth muscle including gastrointestinal smooth muscle, urinary bladder and vascular and airway tissue. Activation of M3 receptors, via the G protein Gq, results in increased polyphosphoinositide hydrolysis, release of Ca2+ ions from the sarcoplasmic reticulum and ...
EGLEN, RM +3 more
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Muscarinic Receptor Subtypes in Lung: Clinical Implications
American Review of Respiratory Disease, 1990Several subtypes of muscarinic receptors have been identified in airways and lung parenchyma of different species, including humans. M1 receptors may be present in parasympathetic ganglia where they appear to facilitate ganglionic neurotransmission.
P A, Minette, P J, Barnes
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Muscarinic receptor subtypes in bovine adrenal medulla
Neurochemical Research, 1992Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to identify the pharmacological ...
J S, Aguilar +5 more
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Muscarinic receptor subtypes in guinea pig airways
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1991The muscarinic receptors present in the guinea pig tracheobronchial tree were characterized using ligand-binding studies and functional approaches. The binding constants of four selective antagonists, pirenzepine,[11-([2-[(diethylamino) methyl]-1-piperidinyl]acetyl)-5,11-dihydro-6H-pyrido(2,3) (1,4) benzodiazepine-6-on] (AF-DX 116), methoctramine, and
E B, Haddad, Y, Landry, J P, Gies
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Overview of Muscarinic Receptor Subtypes
2011The physiological role of muscarinic receptors is highly complex and, although not completely understood, has become clearer over the last decade. Recent pharmacological evidence with novel compounds, together with data from transgenic mice, suggests that all five subtypes have defined functions in the nervous system as well as mediating the non ...
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Muscarinic receptor subtypes in bovine adrenal medulla
Biochemical Pharmacology, 1986Muscarinic receptors in bovine adrenal medullary microsomes were characterized by radioligand binding assay, using l-[3H]quinuclidinyl benzilate (QNB), a muscarinic antagonist. Specific [3H]QNB binding to microsomes was rapid, reversible, saturable and of high affinity. Saturation experiments revealed a single class of binding sites for the radioligand
K, Yamanaka, S, Kigoshi, I, Muramatsu
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SUBTYPES OF THE MUSCARINIC RECEPTOR IN SMOOTH MUSCLE
Life Sciences, 1997Muscarinic receptors are expressed in smooth muscle throughout the body. In most instances, the muscarinic receptor population in smooth muscle is composed of mainly the M2 and M3 subtypes in an 80% to 20% mixture. The M3 subtype mediates phosphoinositide hydrolysis and calcium mobilization, whereas the M2 subtype mediates an inhibition of cAMP ...
F J, Ehlert, R S, Ostrom, G W, Sawyer
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Muscarinic cholinergic receptor subtypes expression by human placenta
Neuroscience Letters, 1997The presence of a cholinergic system in the placenta is suggested by several data, but no information is available concerning cholinergic receptor expression by placenta. The present study was designed to investigate muscarinic cholinergic receptors in sections of human placenta using a radioligand binding techniques with [3H]N-methyl scopolamine ([3H ...
S. K. TAYEBATI +3 more
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Muscarinic Receptor Subtype Pharmacology and Physiology
2005Publisher Summary The role of muscarinic receptors is highly complex. The recent pharmacological evidence with novel compounds, together with data from transgenic mice, suggests that all five subtypes (muscarinic M1, M2, M3, M4, and M5 receptors) have a defined function in both peripheral and central nervous systems.
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Muscarinic receptor subtypes insubtypes in Airways
Trends in Pharmacological Sciences, 1988Abstract Subtypes of muscarinic receptor have recently been shown to exist in the airways of several species, including humans. M 1 receptors may be present in sympathetic nerves and parasympathetic ganglia. M 2 receptors on cholinergic nerves (autoreceptors) and M 3 receptors on smooth muscle and mucus glands .
Peter J. Barnes +2 more
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