Results 121 to 130 of about 2,572,202 (339)

Treating cancer cachexia to treat cancer

Skeletal Muscle, 2011
Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in cachectic patients, a major research focus ...
Lee Se-Jin, Glass David J
doaj   +1 more source

Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.

JCI Insight, 2019
Diabetes mellitus is associated with various disorders of the locomotor system including the decline in mass and function of skeletal muscle. The mechanism underlying this association has remained ambiguous, however. We now show that the abundance of the
Y. Hirata, K. Nomura, Yoko Senga, Y. Okada, Kenta Kobayashi, S. Okamoto, Y. Minokoshi, M. Imamura, S. Takeda, T. Hosooka, W. Ogawa   +10 more
semanticscholar   +1 more source

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi   +9 more
wiley   +1 more source

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy [PDF]

, 2013
BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing ...
Gillingwater, T. H., Hunter, G., Lamont, D. J., Mutsaers, C. A., Wishart, T. M.   +4 more
core   +3 more sources

Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population

Skeletal Muscle, 2011
Background A hallmark of muscular dystrophies is the replacement of muscle by connective tissue. Muscle biopsies from patients severely affected with facioscapulohumeral muscular dystrophy (FSHD) may contain few myogenic cells.
Stadler Guido, Chen Jennifer CJ, Wagner Kathryn, Robin Jerome D, Shay Jerry W, Emerson Jr Charles P, Wright Woodring E   +6 more
doaj   +1 more source

High-dimensional single-cell cartography reveals novel skeletal muscle resident cell populations

bioRxiv, 2018
Adult tissue repair and regeneration require the activation of resident stem/progenitor cells that can self-renew and generate differentiated progeny.
Lorenzo Giordani, Gary J. He, E. Negroni, H. Sakai, Justin Law, M. Siu, Raymond Wan, A. Corneau, S. Tajbakhsh, Tom H. Cheung, F. Le Grand   +10 more
semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro

Skeletal Muscle, 2017
Background The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the genome biology that enables ...
Malina D. Doynova, James F. Markworth, David Cameron-Smith, Mark H. Vickers, Justin M. O’Sullivan   +4 more
doaj   +1 more source

Surgical fatigue syndrome and EDiS3 intervention, should every surgeon need to know how to mitigate muscle skeletal discomfort? [PDF]

Surg Open Sci, 2023
Chávez-Saavedra G, Espinosa-Hinojosa A, Colonna-Márquez LE, Hidalgo-Valadez C, Díaz-Martínez DA, González-Sandoval BV.   +5 more
europepmc   +1 more source