Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles
Advanced Science, EarlyView.Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang +4 more
wiley +1 more source
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation. [PDF]
Nat Prod BioprospectShi Y +7 more
europepmc +1 more source
CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy
Advanced Science, EarlyView.CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan +3 more
wiley +1 more source
Ex Vivo Measurement of Stable Isotope-Labeled Fatty Acid Incorporation Into Phospholipids in Isolated Mice Muscle. [PDF]
Bio ProtocSato T, Miura S.
europepmc +1 more source
Advanced Electronic Materials, EarlyView.An n‐type organic thermoelectric aerogel PB@CNF, based on PBFDO, is fabricated by a two‐step freeze‐drying process with cellulose nanofiber (CNF) as substrate. The aerogels can be used not only as temperature sensing and piezoresistive sensing, but also to form a flexible organic thermoelectric generator with the p‐type aerogel (PH@CNF) based on PEDOT ...
Chan Zhang +6 more
wiley +1 more source
Stem Cells Associated with Adult Skeletal Muscle Can Form Beating Cardiac Tissue In Vitro in Response to Media Containing Heparin, Dexamethasone, Growth Factors and Hydrogen Peroxide. [PDF]
Int J Mol SciEisenberg LM, Eisenberg CA.
europepmc +1 more source
Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring
Advanced Electronic Materials, EarlyView.Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park +5 more
wiley +1 more source
Longitudinal association between statins and changes in CT-derived body composition in patients with abdominal aortic aneurysm. [PDF]
J Cachexia Sarcopenia MuscleBradley NA +7 more
europepmc +1 more source
Deciphering the role of IGFBP5 in delaying fibrosis and sarcopenia in aging skeletal muscle: therapeutic implications and molecular mechanisms. [PDF]
Front PharmacolShi L, Ding Z, Chen J.
europepmc +1 more source
AGING MEDICINE, EarlyView.This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang +2 more
wiley +1 more source